dbPTM

NDUS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUS1_MOUSE
UniProt AC	Q91VD9
Protein Name	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene Name	Ndufs1
Organism	Mus musculus (Mouse).
Sequence Length	727
Subcellular Localization	Mitochondrion inner membrane. Matrix and cytoplasmic side of the mitochondrial inner membrane..
Protein Description	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity)..
Protein Sequence	MLRIPIKRALIGLSNSPKGYVRTTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQNFEGNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLGSSALQRDDGAAILVAVSNMVQKIRVTTGVAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQEVLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	S-nitrosylation	GMQIPRFCYHERLSV CCCCCCCCCCCCCCC	3.41	21278135
64	S-nitrosocysteine	GMQIPRFCYHERLSV CCCCCCCCCCCCCCC	3.41	-
64	S-palmitoylation	GMQIPRFCYHERLSV CCCCCCCCCCCCCCC	3.41	26165157
75	S-nitrosocysteine	RLSVAGNCRMCLVEI CCCCCCCCEEEEEEH	2.61	-
75	S-nitrosylation	RLSVAGNCRMCLVEI CCCCCCCCEEEEEEH	2.61	21278135
75	S-palmitoylation	RLSVAGNCRMCLVEI CCCCCCCCEEEEEEH	2.61	28526873
75	Glutathionylation	RLSVAGNCRMCLVEI CCCCCCCCEEEEEEH	2.61	24333276
78	S-palmitoylation	VAGNCRMCLVEIEKA CCCCCEEEEEEHHHC	1.67	28526873
78	Glutathionylation	VAGNCRMCLVEIEKA CCCCCEEEEEEHHHC	1.67	24333276
84	Acetylation	MCLVEIEKAPKVVAA EEEEEHHHCCHHHHH	75.54	23576753
84	Malonylation	MCLVEIEKAPKVVAA EEEEEHHHCCHHHHH	75.54	26320211
84	Succinylation	MCLVEIEKAPKVVAA EEEEEHHHCCHHHHH	75.54	23806337
92	S-nitrosylation	APKVVAACAMPVMKG CCHHHHHHHCCCCCC	2.10	21278135
92	S-nitrosocysteine	APKVVAACAMPVMKG CCHHHHHHHCCCCCC	2.10	-
92	S-palmitoylation	APKVVAACAMPVMKG CCHHHHHHHCCCCCC	2.10	28526873
98	Acetylation	ACAMPVMKGWNILTN HHHCCCCCCCHHCCC	62.09	23864654
98	Succinylation	ACAMPVMKGWNILTN HHHCCCCCCCHHCCC	62.09	24315375
108	Acetylation	NILTNSEKSKKAREG HHCCCCHHHHHHHHH	68.35	23864654
170	Ubiquitination	KNIGPLVKTIMTRCI CCHHHHHHHHHHHHH	39.76	-
170	Acetylation	KNIGPLVKTIMTRCI CCHHHHHHHHHHHHH	39.76	24062335
236	Phosphorylation	GALTSKPYAFTARPW CHHCCCCEEEECCCC	20.34	-
248	Phosphorylation	RPWETRKTESIDVMD CCCCCCCCCCCEEEH	31.51	30635358
250	Phosphorylation	WETRKTESIDVMDAV CCCCCCCCCEEEHHC	29.35	20495213
259	Phosphorylation	DVMDAVGSNIVVSTR EEEHHCCCCEEEECC	19.45	30635358
264	Phosphorylation	VGSNIVVSTRTGEVM CCCCEEEECCCHHHH	10.98	30635358
265	Phosphorylation	GSNIVVSTRTGEVMR CCCEEEECCCHHHHH	22.20	30635358
267	Phosphorylation	NIVVSTRTGEVMRIL CEEEECCCHHHHHHH	37.47	30635358
298	Ubiquitination	RFAYDGLKRQRLTEP HHCCCCHHHCCCCCC	52.60	-
298	Acetylation	RFAYDGLKRQRLTEP HHCCCCHHHCCCCCC	52.60	24062335
311	Succinylation	EPMVRNEKGLLTYTS CCCCCCCCCCEEECC	59.41	26388266
311	Ubiquitination	EPMVRNEKGLLTYTS CCCCCCCCCCEEECC	59.41	-
311	Acetylation	EPMVRNEKGLLTYTS CCCCCCCCCCEEECC	59.41	23864654
367	S-palmitoylation	KVDSDNLCTEEIFPT HCCCCCCCCCCCCCC	5.88	28526873
367	S-nitrosocysteine	KVDSDNLCTEEIFPT HCCCCCCCCCCCCCC	5.88	-
367	S-nitrosylation	KVDSDNLCTEEIFPT HCCCCCCCCCCCCCC	5.88	21278135
448	Phosphorylation	RYDHLGDSPKILQDI ECCCCCCCHHHHHHH	26.71	27841257
450	Acetylation	DHLGDSPKILQDIAS CCCCCCHHHHHHHHC	61.06	23864654
450	Succinylation	DHLGDSPKILQDIAS CCCCCCHHHHHHHHC	61.06	23806337
457	Phosphorylation	KILQDIASGRHSFCE HHHHHHHCCCCCHHH	36.37	23140645
461	Phosphorylation	DIASGRHSFCEVLKD HHHCCCCCHHHHHHH	30.17	26745281
463	S-nitrosylation	ASGRHSFCEVLKDAK HCCCCCHHHHHHHCC	3.86	21278135
463	S-palmitoylation	ASGRHSFCEVLKDAK HCCCCCHHHHHHHCC	3.86	28526873
463	S-nitrosocysteine	ASGRHSFCEVLKDAK HCCCCCHHHHHHHCC	3.86	-
467	Acetylation	HSFCEVLKDAKKPMV CCHHHHHHHCCCCEE	61.90	23576753
470	Acetylation	CEVLKDAKKPMVVLG HHHHHHCCCCEEEEC	68.49	23201123
499	Acetylation	AVSNMVQKIRVTTGV EEHHHHHHCCCCCCC	22.52	23576753
531	Ubiquitination	AALDLGYKPGVEAIR HHHHCCCCCCHHHHH	33.23	-
539	Acetylation	PGVEAIRKNPPKMLF CCHHHHHHCCCCEEE	68.63	24062335
543	Acetylation	AIRKNPPKMLFLLGA HHHHCCCCEEEEEEC	49.87	23864654
554	S-nitrosylation	LLGADGGCITRQDLP EEECCCCEECCCCCC	3.34	21278135
554	S-nitrosocysteine	LLGADGGCITRQDLP EEECCCCEECCCCCC	3.34	-
554	S-palmitoylation	LLGADGGCITRQDLP EEECCCCEECCCCCC	3.34	28526873
562	Acetylation	ITRQDLPKDCFIVYQ ECCCCCCCCEEEEEC	74.54	23864654
564	S-nitrosylation	RQDLPKDCFIVYQGH CCCCCCCEEEEECCC	2.90	21278135
564	S-nitrosocysteine	RQDLPKDCFIVYQGH CCCCCCCEEEEECCC	2.90	-
564	S-palmitoylation	RQDLPKDCFIVYQGH CCCCCCCEEEEECCC	2.90	28680068
611	Phosphorylation	QQTKVAVTPPGLARE EEEEEEECCCCHHHH	17.64	-
636	Nitration	IAGITLPYDTLDQVR HHCCCCCCHHHHHHH	25.36	-
650	Phosphorylation	RNRLEEVSPNLVRYD HHHHHHHCCCCCCCC	16.02	25159016
692	Acetylation	VPPQLTIKDFYMTDS CCCCCEEHHEEECHH	36.23	23954790
692	Succinylation	VPPQLTIKDFYMTDS CCCCCEEHHEEECHH	36.23	23954790
706	Phosphorylation	SISRASQTMAKCVKA HHHHHHHHHHHHHHH	19.32	28576409
709	Succinylation	RASQTMAKCVKAVTE HHHHHHHHHHHHHHH	28.83	23806337
709	Acetylation	RASQTMAKCVKAVTE HHHHHHHHHHHHHHH	28.83	23576753
710	S-nitrosocysteine	ASQTMAKCVKAVTEG HHHHHHHHHHHHHHH	2.49	-
710	S-nitrosylation	ASQTMAKCVKAVTEG HHHHHHHHHHHHHHH	2.49	21278135
725	Phosphorylation	AQAVEEPSIC----- HHHHCCCCCC-----	39.61	23140645
727	S-palmitoylation	AVEEPSIC------- HHCCCCCC-------	5.53	28526873
727	S-nitrosocysteine	AVEEPSIC------- HHCCCCCC-------	5.53	-
727	S-nitrosylation	AVEEPSIC------- HHCCCCCC-------	5.53	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUS1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	K	Acetylation		23576753
Acetylation of Lys-84 is observed in liver mitochondria from fasted mice but not from fed mice.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NDUS1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUS1_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-84, AND MASS SPECTROMETRY.	16916647 [Abstract]

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