EXOSX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOSX_MOUSE
• UniProt AC: P56960
• Protein Name: Exosome component 10
• Gene Name: Exosc10
• Organism: Mus musculus (Mouse).
• Sequence Length: 887
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Nucleus.
• Protein Description: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA (By similarity)..
• Protein Sequence: MAPPSPREHQSAPATSATKPDAEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEYDFYRSFPAFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDTNDVILERVGMLLDEASGVNKHQQPVLPAGLQVPKTIVSSWNRKAGEYGKKAKSETFRLLHAKNIVRPQLRFREKIDNSNTPFLPKIFVKPNARKPLPLALSKERRERPQDRPEDLDVPPALADFIHQQRTQQVEQDMFAHPYQYELDHFTPPQSVLQRPKPQLYRAVGETPCHLVSSLDELVELNEKLLGCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIVDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLARHSLDHLLRLYCGVESNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDRMRLELWERGNHQPVQLQVVWQRSRDICLKKFVKPIFTDESYLELYRKQKKHLNSQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSENAAGVRKSGPLPSAERLENDLFGPHDCSHAPPDNYQNTSTDGTLPLQKQPSLFTEGKEETSVDAGCLLATAVITLFSEPNTEEGGKTPLTVAQKKAQNIMQSFENPFRMFLPSLEHKAHISQAAKFDPSSKIYEISNRWKLASQVQVQKEPKEATKKKVAEQTAAREEAKEEAAAGVLEQAIPVRQQAALENATKKRERATSDLRTIEQKQEKKRLKSSKKAKDPDPPGKDFSPYDYSQSDFRAFAGDSKSKPSSQFDPNKLAPSGKKGVGAKKCKQSVGNKSMSFAVGKSDRGFRHNWPKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAPPSPREHQSA ---CCCCCCCCCCCC	35.21	30352176
11	Phosphorylation	PSPREHQSAPATSAT CCCCCCCCCCCCCCC	37.82	26643407
15	Phosphorylation	EHQSAPATSATKPDA CCCCCCCCCCCCCCH	20.17	26643407
16	Phosphorylation	HQSAPATSATKPDAE CCCCCCCCCCCCCHH	35.73	26643407
18	Phosphorylation	SAPATSATKPDAEMV CCCCCCCCCCCHHHC	42.76	26643407
593	Phosphorylation	NAAGVRKSGPLPSAE CCCCCCCCCCCCCHH	34.77	28066266
636	Phosphorylation	LPLQKQPSLFTEGKE CCCCCCCCCCCCCCC	33.35	29514104
698	Phosphorylation	PFRMFLPSLEHKAHI HHHHHHHHHHHHHHH	48.84	23737553
710	Acetylation	AHISQAAKFDPSSKI HHHHHHHCCCCCCCE	54.00	22826441
818	Phosphorylation	DPPGKDFSPYDYSQS CCCCCCCCCCCCCHH	32.46	26643407
820	Phosphorylation	PGKDFSPYDYSQSDF CCCCCCCCCCCHHHH	26.73	28066266
823	Phosphorylation	DFSPYDYSQSDFRAF CCCCCCCCHHHHHHH	21.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOSX_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOSX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOSX_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOSX_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.