WDR12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR12_MOUSE
• UniProt AC: Q9JJA4
• Protein Name: Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
• Gene Name: Wdr12
• Organism: Mus musculus (Mouse).
• Sequence Length: 423
• Subcellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm .
• Protein Description: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome..
• Protein Sequence: MAQLQARFYSENKKYAVDDVPFSIPAAAEVADLSNIINKLLETKNELHKHVEFDFLIKGQFLRVPLVKHMELENISSEEVVELEYVEKYTAPQPEQCMFHDDWISSIEGAEEWILSGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLTASMDQTVLLWEWNVEKNKVKALHCCRGHAGSVDAIAVDSSGAKFCSGSWDKMLKIWSTVPTDEEDEMEEATNRPRKKQKTEQLGLTRTPLVTLSGHTEAISSVLWSDAEEICSASWDHTIRVWDVESGGLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYSYSPTTSHVGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQLQARFY ------CCHHHHHHH	20.84	-
15	Phosphorylation	FYSENKKYAVDDVPF HHCCCCCEEECCCCC	17.29	20139300
23	Phosphorylation	AVDDVPFSIPAAAEV EECCCCCCCHHHHHH	22.92	20139300
217	Phosphorylation	DKMLKIWSTVPTDEE HHHHHHEEECCCCCH	24.01	28066266
218	Phosphorylation	KMLKIWSTVPTDEED HHHHHEEECCCCCHH	18.60	28066266
221	Phosphorylation	KIWSTVPTDEEDEME HHEEECCCCCHHHHH	52.27	25159016
231	Phosphorylation	EDEMEEATNRPRKKQ HHHHHHHHCCCCHHH	34.73	28066266
413	Phosphorylation	DNKLYSYSYSPTTSH CCCEEEEEECCCCCC	17.13	26643407
415	Phosphorylation	KLYSYSYSPTTSHVG CEEEEEECCCCCCCC	15.16	26643407
417	Phosphorylation	YSYSYSPTTSHVGA- EEEEECCCCCCCCC-	34.68	26643407
418	Phosphorylation	SYSYSPTTSHVGA-- EEEECCCCCCCCC--	21.88	26643407
419	Phosphorylation	YSYSPTTSHVGA--- EEECCCCCCCCC---	20.75	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTC1_MOUSE	Notch1	physical	11827460

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.