FBX11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX11_MOUSE
• UniProt AC: Q7TPD1
• Protein Name: F-box only protein 11
• Gene Name: Fbxo11
• Organism: Mus musculus (Mouse).
• Sequence Length: 930
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53..
• Protein Sequence: MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPPQPPQQPPQQQPPPPPQQQPPPPPPPPPPPPQDRNNAGERDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56 (in isoform 3)	Phosphorylation	-	34.64	25338131
100	Phosphorylation	SGPGAQNSPYQLRRK CCCCCCCCHHHHCHH	35.76	26370283
145	Acetylation	KRARVSGKSQDLSAA HHHCCCCCCCCCCCC	36.32	-
145	Acetylation	KRARVSGKSQDLSAA HHHCCCCCCCCCCCC	36.32	23806337
157	Phosphorylation	SAAPAEQYLQEKLPD CCCCHHHHHHHHCCH	59.21	28494245
490	Phosphorylation	AGFEVKAYANPTVVR CEEEEEEECCCEEEE	2.27	25777480
494	Phosphorylation	VKAYANPTVVRCEIH EEEECCCEEEEEEEE	32.87	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX11_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FBX11_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.