GET4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GET4_MOUSE
• UniProt AC: Q9D1H7
• Protein Name: Golgi to ER traffic protein 4 homolog
• Gene Name: Get4
• Organism: Mus musculus (Mouse).
• Sequence Length: 327
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome..
• Protein Sequence: MAAAAAMAEQEGARNGARNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQSKHAEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVDVADELLENLAKVFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYCESRYHFLHSSDGEGCANMLVEYSTARGFRSEVDMFVAQAVLQFLCLKNKNSALVVFTTYTQKHPSIEDGPPFVQPLLNFIWFLLLAVDGGKLAVFTVLCEQYQPSLRRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLSSLMGSSEQEEGEESQDDSSPIELD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAAMAE ------CHHHHHHHH	13.05	-
33	Phosphorylation	VEGKLRASVEKGDYY EECEEEEHHCCCCHH	25.11	24719451
39	Phosphorylation	ASVEKGDYYEAHQMY EHHCCCCHHHHHHHH	16.33	-
53	Phosphorylation	YRTLFFRYMSQSKHA HHHHHHHHHHCCCCH	8.93	24719451
55	Phosphorylation	TLFFRYMSQSKHAEA HHHHHHHHCCCCHHH	23.51	24719451
78	Ubiquitination	LLFFSHGQQNSAADL CEEEECCCCCCHHHH	33.58	27667366
130	Ubiquitination	VAFVSRALKWSSGGS HHHHHHHHHCCCCCC	5.92	27667366
131	Ubiquitination	AFVSRALKWSSGGSG HHHHHHHHCCCCCCC	44.00	27667366
293	Phosphorylation	VPPKQTSSYGGLLGN CCCCCCCCHHHHHHH	31.05	23649490
303	Phosphorylation	GLLGNLLSSLMGSSE HHHHHHHHHHHCCCC	25.29	23649490
304	Phosphorylation	LLGNLLSSLMGSSEQ HHHHHHHHHHCCCCC	23.50	23737553
308	Phosphorylation	LLSSLMGSSEQEEGE HHHHHHCCCCCCCCC	19.41	23737553
309	Phosphorylation	LSSLMGSSEQEEGEE HHHHHCCCCCCCCCC	37.25	23737553
317	Phosphorylation	EQEEGEESQDDSSPI CCCCCCCCCCCCCCC	34.31	23737553
321	Phosphorylation	GEESQDDSSPIELD- CCCCCCCCCCCCCC-	46.43	23649490
322	Phosphorylation	EESQDDSSPIELD-- CCCCCCCCCCCCC--	36.57	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GET4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GET4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GET4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASNA_HUMAN	ASNA1	physical	26496610
PYR1_HUMAN	CAD	physical	26496610
ACSL3_HUMAN	ACSL3	physical	26496610
HS90B_HUMAN	HSP90AB1	physical	26496610
METK2_HUMAN	MAT2A	physical	26496610
PSMD4_HUMAN	PSMD4	physical	26496610
RNF5_HUMAN	RNF5	physical	26496610
HLTF_HUMAN	HLTF	physical	26496610
HTF4_HUMAN	TCF12	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
UBL4A_HUMAN	UBL4A	physical	26496610
BAG2_HUMAN	BAG2	physical	26496610
TRAD1_HUMAN	TRAFD1	physical	26496610
MAGD2_HUMAN	MAGED2	physical	26496610
TEST_HUMAN	PRSS21	physical	26496610
AT132_HUMAN	ATP13A2	physical	26496610
ATX10_HUMAN	ATXN10	physical	26496610
RN126_HUMAN	RNF126	physical	26496610
SRPRB_HUMAN	SRPRB	physical	26496610
USMG5_HUMAN	USMG5	physical	26496610
LAMA1_HUMAN	LAMA1	physical	26496610
UBAC2_HUMAN	UBAC2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.