INT8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT8_MOUSE
• UniProt AC: Q80V86
• Protein Name: Integrator complex subunit 8
• Gene Name: Ints8
• Organism: Mus musculus (Mouse).
• Sequence Length: 995
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity)..
• Protein Sequence: MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKACPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRVLKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLSALPPTTAMAILLYNRWAIRTIVQSSFPVKQAKPGPPQLNVMNQMQQEKELTENILKVLKEQAADCILVLEAALRLNKDLYVHTMRTLDLLAVEPGTVNGETENSTAGLKIRTEEMQCQVCYDLGAAYFQQGSTDSAIYENAREKFFRTKELLAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDNNSQQLTPYSQVHICLRSGSYQEVVQIFIEDNLTFTLPVQFRQSVLRELFQKAQQGNEALDEICFKICVCNTVRDVLEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSINVEKASDSLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSSVILGIKDNLTRDLVYILMAKGLHCSTVKDFPHSKQLFTACLELVTEFSPKLRQVMLNEMLLLDIRTHEAGVGQSGERPPSDLISRVRGYLEMRLPDIPLRQVVAEECVAFMLNWRENEYLTLQVPAFLFQNNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSNQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHAWLIIQADIYFATNQHSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAEAADRE ------CCHHHHHHH	34.51	23984901
12	Phosphorylation	AADREAATSSRPCTP HHHHHHHHCCCCCCC	33.99	25777480
13	Phosphorylation	ADREAATSSRPCTPP HHHHHHHCCCCCCCC	21.44	25777480
14	Phosphorylation	DREAATSSRPCTPPQ HHHHHHCCCCCCCCC	35.57	25777480
18	Phosphorylation	ATSSRPCTPPQTCWF HHCCCCCCCCCCHHH	40.46	26643407
22	Phosphorylation	RPCTPPQTCWFEFLL CCCCCCCCHHHHHHH	19.92	25777480
460	Phosphorylation	LQYVFMISSHELFIT HCEEEEEECHHHHHH	17.54	-
467	Phosphorylation	SSHELFITLLKDEER ECHHHHHHHCCHHHH	20.78	-
985	Succinylation	AAQRRKKKFLQAMAK HHHHHHHHHHHHHHH	55.10	24315375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of INT8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.