SSRG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSRG_MOUSE
• UniProt AC: Q9DCF9
• Protein Name: Translocon-associated protein subunit gamma
• Gene Name: Ssr3
• Organism: Mus musculus (Mouse).
• Sequence Length: 185
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins..
• Protein Sequence: MAPKGGSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVLVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPKGGSK -------CCCCCCCC	15.08	-
7	Phosphorylation	-MAPKGGSKQQSEED -CCCCCCCCCCCHHH	35.64	27149854
8	Ubiquitination	MAPKGGSKQQSEEDL CCCCCCCCCCCHHHH	56.48	-
11	Phosphorylation	KGGSKQQSEEDLLLQ CCCCCCCCHHHHHHH	40.22	25521595
81	Ubiquitination	AFAYKNVKFVLKHKV HHHHHCHHHHHHHHH	38.87	-
101	Phosphorylation	DAVSKEVTRKLSEAD HHHCHHHHHHHHHHH	24.15	20469934
105	Phosphorylation	KEVTRKLSEADNRKM HHHHHHHHHHHHHHC	33.50	26824392
105 (in isoform 2)	Phosphorylation	-	33.50	19144319
113	Phosphorylation	EADNRKMSRKEKDER HHHHHHCCHHHHHHH	43.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSRG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSRG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSRG_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SSRG_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.
PubMed: 19144319