UN45A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UN45A_MOUSE
• UniProt AC: Q99KD5
• Protein Name: Protein unc-45 homolog A
• Gene Name: Unc45a
• Organism: Mus musculus (Mouse).
• Sequence Length: 944
• Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Predominant in the perinuclear region. Little protein in the nucleus (By similarity)..
• Protein Description: May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen..
• Protein Sequence: MTVSGPETPEPRPSDPGASSAEQLRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTEETDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVIFDALKEGVKKGFRGKEGAIIVDPARELKVLINSLLELLTEVGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSLQDAAGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIRNWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEREEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPALCSRIPQVTTHWLEILQALLLSPNQELQHRGTVVVLNMMQSSKEIAGTLMESEVLEILSVLAKGEESPVTRAAAACLEKAVEYRLIQPNQDGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MTVSGPETPEP ----CCCCCCCCCCC	39.19	25338131
8	Phosphorylation	MTVSGPETPEPRPSD CCCCCCCCCCCCCCC	35.76	25338131
70	Malonylation	NRAACHLKLEDYSKA CCEEHHCCHHHHHHH	26.60	26320211
70	Acetylation	NRAACHLKLEDYSKA CCEEHHCCHHHHHHH	26.60	-
120	Phosphorylation	LDLKRCVSLEPKNKV HHHHHHHCCCCCCHH	30.55	29514104
126	Malonylation	VSLEPKNKVFQESLR HCCCCCCHHHHHHHH	51.02	26320211
230	Phosphorylation	CSEHQSRTVATLSVL HCHHCCCCEEEEHHC	21.53	-
353	Phosphorylation	KILEVGGSLQDAAGE HHHHCCCCHHHHCCE	19.54	25367039
362	Phosphorylation	QDAAGELTVTANSRM HHHCCEEEEECCCHH	16.11	25367039
364	Phosphorylation	AAGELTVTANSRMSA HCCEEEEECCCHHHH	18.19	25367039
367	Phosphorylation	ELTVTANSRMSASIL EEEEECCCHHHHHHH	27.22	25367039
370	Phosphorylation	VTANSRMSASILLSK EECCCHHHHHHHHHH	20.11	25367039
372	Phosphorylation	ANSRMSASILLSKLF CCCHHHHHHHHHHHH	13.38	25367039
483	Acetylation	ANGVSLLKDLYKGSE ECHHHHHHHHHCCCC	51.48	-
532	Acetylation	KLAKQCRKWLCNDQI HHHHHHHHHHHCCCC	52.74	22826441
562	Ubiquitination	TFDADVKEEFVEDEA EECCCCCHHHHCCHH	57.42	27667366
692	Ubiquitination	VAQGGGKALLPLALE EEECCCCEEEEEECC	20.01	27667366
707	Ubiquitination	GTDVGQTKAAQALAK CCCCCHHHHHHHHHH	33.56	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UN45A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UN45A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UN45A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UN45A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.