SYIC_MOUSE - dbPTM
SYIC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYIC_MOUSE
UniProt AC Q8BU30
Protein Name Isoleucine--tRNA ligase, cytoplasmic
Gene Name Iars
Organism Mus musculus (Mouse).
Sequence Length 1262
Subcellular Localization Cytoplasm . Cytoplasm, cytosol .
Protein Description Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA..
Protein Sequence MVQQVPENISFPAEEEKILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNFESNQNYKDVQDPSVFVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPEIQYVKIKDVARGKLFILTEARLSALYKQESDYEILERFPGASLKGKKYKPLFDYFIKCKENGAFTVLVDHYVKDEEGTGVVHQAPYFGADDHRVCMDFNIIQKDSVPVCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLAAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEFVREKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEVVCIGSVAELEELSGTKISDLHRESIDHLTIPSRCGKAPLRRVSEVFDCWFESGSMPYAQVHYPFESKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFFIQNVFRLHKEEEVKFLYNEHTVRESPNITDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKLLIDPASLRDKDTLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALEDIRSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMMAIKRLSNEELERFQKSGSIVVEGHELHEEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYNAKSEGRYLNNVIESHTDFIFATIKAPLKPYPVPTSDNILIQEQTQLKGSELEITLTKGSCVPGPACAYVNLNICANGTEQGGVLLLENPKGDNQLNLVKLKTVVTSVFGVKNAKLSVFHGETEIQNQTDLLSLSGRTLCVTAGASPSPISSPSTLLCQYLNLQLLNAEPQECLTGTVGTLLLENPLGQNGLTHQGLVHEAAKVFGLRSRRLRLFLNETQTQEITEDIPMKTLNMKTVYVSVLPTTADG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVQQVPEN
-------CCCCCCCC		29.34-
23PhosphorylationEKILEFWSKHNCFQE
HHHHHHHHHCCHHHH		29.3820469934
24SumoylationKILEFWSKHNCFQEC
HHHHHHHHCCHHHHH		29.4528289178
87GlutathionylationDRRFGWDCHGLPVEY
CCCCCCCCCCCEEEE		1.9024333276
110UbiquitinationKGPEDVAKMGIAEYN
CCHHHHHHHCHHHHH		37.1922790023
120GlutathionylationIAEYNKQCRAIVMRY
HHHHHHHHCHHHHHH		3.2024333276
177UbiquitinationGLVYRGVKVMPFSTA
CCEECCEEEEECCCC		35.3222790023
254AcetylationIKDVARGKLFILTEA
EEHHHCCCEEEEEHH		34.3722826441
268AcetylationARLSALYKQESDYEI
HHHHHHHCCCCCHHH		48.7322826441
288AcetylationGASLKGKKYKPLFDY
CCCCCCCCCCCHHHE		68.1522826441
290UbiquitinationSLKGKKYKPLFDYFI
CCCCCCCCCHHHEEE		44.0922790023
306PhosphorylationCKENGAFTVLVDHYV
ECCCCCEEEEEEEEE		16.6423882026
336GlutathionylationGADDHRVCMDFNIIQ
CCCCCCEEEECCEEC		1.8724333276
350GlutathionylationQKDSVPVCPVDASGC
CCCCCCCCCCCCCCC		1.9124333276
375MalonylationQYVKDADKNIIRMLK
HHHCHHCHHHHHHHH		52.3326320211
375AcetylationQYVKDADKNIIRMLK
HHHCHHCHHHHHHHH		52.3323806337
410UbiquitinationSDTPLIYKSVPSWFV
CCCCCEECCCCCCEE		37.6722790023
434PhosphorylationLKNNDLCYWVPEFVR
HHCCCCEEECHHHHH		19.4222817900
496PhosphorylationELSGTKISDLHRESI
HHHCCCCHHHHHHHC		35.3626060331
502PhosphorylationISDLHRESIDHLTIP
CHHHHHHHCCCCCCC		33.0226824392
521PhosphorylationKAPLRRVSEVFDCWF
CCCCCCHHHHHHHHC		26.6525266776
530PhosphorylationVFDCWFESGSMPYAQ
HHHHHCCCCCCCCEE		27.0525777480
532PhosphorylationDCWFESGSMPYAQVH
HHHCCCCCCCCEEEE		26.3425777480
535PhosphorylationFESGSMPYAQVHYPF
CCCCCCCCEEEECCC		10.8725777480
540PhosphorylationMPYAQVHYPFESKRE
CCCEEEECCCCCCCC		15.6825777480
544PhosphorylationQVHYPFESKREFEDA
EEECCCCCCCCHHHC		37.0725777480
600UbiquitinationILASDGQKMSKRKKN
EECCCCCCCCCCCCC		51.1522790023
606MalonylationQKMSKRKKNYPDPVS
CCCCCCCCCCCCCCH		66.7926320211
613PhosphorylationKNYPDPVSIIDKYGA
CCCCCCCHHHHHHCH		21.1529899451
618PhosphorylationPVSIIDKYGADALRL
CCHHHHHHCHHHHHH		17.5029899451
630PhosphorylationLRLYLINSPVVRAEN
HHHHEECCCCCCHHH		16.4528066266
677AcetylationLHKEEEVKFLYNEHT
CCCHHHHHHHCCCCC		32.6923954790
796AcetylationDPASLRDKDTLSIHY
CHHHCCCCCCEEEEE		46.2923806337
796UbiquitinationDPASLRDKDTLSIHY
CHHHCCCCCCEEEEE		46.2922790023
798PhosphorylationASLRDKDTLSIHYLM
HHCCCCCCEEEEEEE		28.31-
800PhosphorylationLRDKDTLSIHYLMLP
CCCCCCEEEEEEECH		14.93-
827PhosphorylationNAVSRMQSVIELGRV
HHHHHHHHHHHHHCH		18.7329514104
844AcetylationDRKTIPIKYPLKEIV
CCCCCCCCCCCCEEE		35.1523236377
903UbiquitinationPDHMVLGKRLKGAFK
CCCEECHHHHHHHHH		50.8527667366
920PhosphorylationMMAIKRLSNEELERF
HHHHHHCCHHHHHHH		46.3525338131
1042AcetylationATIKAPLKPYPVPTS
EEECCCCCCCCCCCC		41.2523806337
1049PhosphorylationKPYPVPTSDNILIQE
CCCCCCCCCCEEEEE		23.69-
1058PhosphorylationNILIQEQTQLKGSEL
CEEEEECCCCCCCEE		34.81-
1125UbiquitinationVTSVFGVKNAKLSVF
EEHHHCCCCCEEEEE		52.1222790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYIC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYIC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYIC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYIC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYIC_MOUSE

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Related Literatures of Post-Translational Modification

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