TBC9B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC9B_MOUSE
• UniProt AC: Q5SVR0
• Protein Name: TBC1 domain family member 9B
• Gene Name: Tbc1d9b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1263
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: May act as a GTPase-activating protein for Rab family protein(s)..
• Protein Sequence: MWLGPEEVLVANALWVTERANPFFVLQRRRGHGKGGGLTGLLVGTLDVVLDSSARVAPYRILHQTQDSQVYWIVACGSSRKEITKHWEWLENNLLQTLSIFDNEEDITTFVKGKIHGIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCNFWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSLVVQWVDVTRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHKNISALKRDLDARAKNECYRATFRLPKDERLDGHTGCTLWTPFNKLHIPGQMFISNNYICFASKEEDACRLIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQTGSSIGGTKASVSDPAPESLPTPQEASEPPASPSSPLSSPPSFSTQEIPTTSQGLLKVFQKNSPMEDLGAKGAKEKMKEESWNIHFFEYGRGMCMYRTAKTRELVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSLGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDVLPRLSEKMQELGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANVEQLLDCNDEGEAMTVLGRYLDNVVNKQSISPPIPHLHALLTSGDDPPVEVDIFDLLRVSYEKFSNLRADDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPGDIGFSIEELEDLYMVFKAKHLASQYWGGNRSAAVHRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPVLAGRMFRLLDQNKDSLINFKEFVTGMSGMYHGDLTEKLKALYKLHLPPALIPEEAESALEAAHYFTEDSSSEASPLASDLDLFLPWEAQALLQEQQEGSGNEDTPERREEKGTSPPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSALTTKKPRDGAHSGDPNSATEEDEPPTPKLHQDPTQECQPPAAGDRQAKASGDMHLGKALQDSHVIVEGGSGEGQGSPSLLLSDDETKDDMSMSSYSVVSTGSLQCEDLTEDTVLVGGGACSPTATSRAGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTSSDHEPPGVLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
275	Phosphorylation	IRPHKNISALKRDLD CCCCCCHHHHHHHHH	36.62	29176673
391	Phosphorylation	DFLVQRISDFLQKTP HHHHHHHHHHHHHCC	25.21	21454597
397	Phosphorylation	ISDFLQKTPSKQTGS HHHHHHHCCCCCCCC	21.60	26824392
399	Phosphorylation	DFLQKTPSKQTGSSI HHHHHCCCCCCCCCC	42.50	29176673
412	Phosphorylation	SIGGTKASVSDPAPE CCCCCCCCCCCCCCC	24.57	25293948
414	Phosphorylation	GGTKASVSDPAPESL CCCCCCCCCCCCCCC	35.07	25293948
423	Phosphorylation	PAPESLPTPQEASEP CCCCCCCCCCCCCCC	42.78	25293948
428	Phosphorylation	LPTPQEASEPPASPS CCCCCCCCCCCCCCC	50.30	25293948
433	Phosphorylation	EASEPPASPSSPLSS CCCCCCCCCCCCCCC	30.96	25293948
435	Phosphorylation	SEPPASPSSPLSSPP CCCCCCCCCCCCCCC	41.93	25338131
436	Phosphorylation	EPPASPSSPLSSPPS CCCCCCCCCCCCCCC	32.99	25293948
439	Phosphorylation	ASPSSPLSSPPSFST CCCCCCCCCCCCCCC	44.15	25293948
440	Phosphorylation	SPSSPLSSPPSFSTQ CCCCCCCCCCCCCCC	48.81	25293948
443	Phosphorylation	SPLSSPPSFSTQEIP CCCCCCCCCCCCCCC	34.90	25293948
445	Phosphorylation	LSSPPSFSTQEIPTT CCCCCCCCCCCCCCC	33.25	25293948
446	Phosphorylation	SSPPSFSTQEIPTTS CCCCCCCCCCCCCCC	28.36	25293948
451	Phosphorylation	FSTQEIPTTSQGLLK CCCCCCCCCCHHHHH	44.75	25293948
452	Phosphorylation	STQEIPTTSQGLLKV CCCCCCCCCHHHHHH	17.44	25293948
453	Phosphorylation	TQEIPTTSQGLLKVF CCCCCCCCHHHHHHH	25.40	25293948
464 (in isoform 2)	Phosphorylation	-	32.43	24719451
464	Phosphorylation	LKVFQKNSPMEDLGA HHHHHCCCCHHHHCC	32.43	25521595
546	Ubiquitination	LVEKSLGKYSLATEE HHHHHCCCCCCCHHH	36.64	22790023
797	Phosphorylation	QRLKVIQSLEDTAKR HHHHHHHCHHHHHHH	23.70	29899451
803	Ubiquitination	QSLEDTAKRSVVRAI HCHHHHHHHHHHHHC	47.50	27667366
854	Phosphorylation	HRDPSLPYLEQYRID CCCCCCHHHHHCCCC	28.32	-
858	Phosphorylation	SLPYLEQYRIDASQF CCHHHHHCCCCHHHH	10.52	-
871	O-linked_Glycosylation	QFRELFASLTPWACG HHHHHHHHCCCCCCC	25.99	55414225
873	O-linked_Glycosylation	RELFASLTPWACGSH HHHHHHCCCCCCCCC	17.81	55414231
903	Acetylation	KDSLINFKEFVTGMS CCCCCCHHHHHHCCC	45.84	15620067
910	Phosphorylation	KEFVTGMSGMYHGDL HHHHHCCCCCCCCCH	23.04	-
920	Acetylation	YHGDLTEKLKALYKL CCCCHHHHHHHHHHH	50.48	15620077
996	Phosphorylation	ERREEKGTSPPDYRH HHHHHCCCCCCCHHH	49.48	25521595
997	Phosphorylation	RREEKGTSPPDYRHY HHHHCCCCCCCHHHH	43.00	25521595
1085	Phosphorylation	KPRDGAHSGDPNSAT CCCCCCCCCCCCCCC	44.34	25619855
1090	Phosphorylation	AHSGDPNSATEEDEP CCCCCCCCCCCCCCC	41.79	25521595
1092	Phosphorylation	SGDPNSATEEDEPPT CCCCCCCCCCCCCCC	39.46	25619855
1099	Phosphorylation	TEEDEPPTPKLHQDP CCCCCCCCCCCCCCC	43.71	25619855
1123	Phosphorylation	GDRQAKASGDMHLGK CCCCCHHHCCCCHHH	34.32	-
1143	Phosphorylation	HVIVEGGSGEGQGSP EEEEECCCCCCCCCC	44.52	25619855
1149	Phosphorylation	GSGEGQGSPSLLLSD CCCCCCCCCCEECCC	11.92	25619855
1151	Phosphorylation	GEGQGSPSLLLSDDE CCCCCCCCEECCCCC	33.09	25619855
1155	Phosphorylation	GSPSLLLSDDETKDD CCCCEECCCCCCCCC	42.88	25619855
1159	Phosphorylation	LLLSDDETKDDMSMS EECCCCCCCCCCCCC	46.93	25619855
1234 (in isoform 2)	Phosphorylation	-	10.48	24719451
1251	Phosphorylation	KKVERQFSTSSDHEP HHHHHHCCCCCCCCC	21.02	30352176
1252	Phosphorylation	KVERQFSTSSDHEPP HHHHHCCCCCCCCCC	33.27	26745281
1253	Phosphorylation	VERQFSTSSDHEPPG HHHHCCCCCCCCCCC	32.35	26745281
1254	Phosphorylation	ERQFSTSSDHEPPGV HHHCCCCCCCCCCCC	42.97	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC9B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC9B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC9B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TJAP1_HUMAN	TJAP1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.