CRNL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRNL1_MOUSE
• UniProt AC: P63154
• Protein Name: Crooked neck-like protein 1
• Gene Name: Crnkl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 690
• Subcellular Localization: Nucleus . Nucleus speckle . Colocalizes with core spliceosomal snRNP proteins.
• Protein Description: Involved in pre-mRNA splicing process..
• Protein Sequence: MAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVERARTIYERFVLVHPAVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQEAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEADTVREVYERAIANVPPIQEKRHWKRYIYLWVNYALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWLYYAQFEIRQKNLPFARRALGTSIGKCPKNKLFKGYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIERARAIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRQLLQRTQHVKVWISFAQFELSSGKEGSVAKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEDEFGTVSDKERVDKLMPEKVKKRRKVQADDGSDAGWEEYYDYIFPEDAANQPNLKLLAMAKLWKKQQQEREAAEQDPDKDIDESESSSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
314	Ubiquitination	IEDIIVSKRRFQYEE HHHEEEECCCCCCHH	36.38	27667366
342	Phosphorylation	DYLRLVESDAEADTV HHHHHHHCCCCCHHH	34.34	28066266
348	Phosphorylation	ESDAEADTVREVYER HCCCCCHHHHHHHHH	28.63	28066266
437	Phosphorylation	FARRALGTSIGKCPK HHHHHHCCCCCCCCC	20.30	22817900
438	Phosphorylation	ARRALGTSIGKCPKN HHHHHCCCCCCCCCC	27.78	22817900
507	Phosphorylation	AIYELAISQPRLDMP HHHHHHHCCCCCCCC	28.64	21183079
608	Phosphorylation	EDEFGTVSDKERVDK CHHHCCCCCHHHHHH	42.68	26525534
640	Phosphorylation	SDAGWEEYYDYIFPE CCCCHHHHHHHCCCH	7.07	22817900
641	Phosphorylation	DAGWEEYYDYIFPED CCCHHHHHHHCCCHH	12.92	22817900
685	Phosphorylation	PDKDIDESESSSF-- CCCCCCCHHCCCC--	38.74	25619855
687	Phosphorylation	KDIDESESSSF---- CCCCCHHCCCC----	40.33	25619855
688	Phosphorylation	DIDESESSSF----- CCCCHHCCCC-----	31.54	25619855
689	Phosphorylation	IDESESSSF------ CCCHHCCCC------	44.23	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRNL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRNL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRNL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPIL2_HUMAN	PPIL2	physical	15189447
HS90A_HUMAN	HSP90AA1	physical	15189447
CDC5L_HUMAN	CDC5L	physical	26496610
DHX8_HUMAN	DHX8	physical	26496610
GOGA4_HUMAN	GOLGA4	physical	26496610
PLRG1_HUMAN	PLRG1	physical	26496610
2ABA_HUMAN	PPP2R2A	physical	26496610
PRCC_HUMAN	PRCC	physical	26496610
AQR_HUMAN	AQR	physical	26496610
SPF27_HUMAN	BCAS2	physical	26496610
PPIE_HUMAN	PPIE	physical	26496610
SLU7_HUMAN	SLU7	physical	26496610
U520_HUMAN	SNRNP200	physical	26496610
SYF2_HUMAN	SYF2	physical	26496610
PRP19_HUMAN	PRPF19	physical	26496610
PRP17_HUMAN	CDC40	physical	26496610
CWC15_HUMAN	CWC15	physical	26496610
SYF1_HUMAN	XAB2	physical	26496610
K1143_HUMAN	KIAA1143	physical	26496610
ISY1_HUMAN	ISY1	physical	26496610
CATIN_HUMAN	CACTIN	physical	26496610
CHD9_HUMAN	CHD9	physical	26496610
ZN830_HUMAN	ZNF830	physical	26496610
CA052_HUMAN	C1orf52	physical	26496610
CCD12_HUMAN	CCDC12	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.