| UniProt ID | CATIN_HUMAN | |
|---|---|---|
| UniProt AC | Q8WUQ7 | |
| Protein Name | Cactin | |
| Gene Name | CACTIN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 758 | |
| Subcellular Localization | Nucleus . Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. | |
| Protein Description | Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.. | |
| Protein Sequence | MGRDTRSRSRSAGRRGRRRQSQSGSRSRSRSHGRRNRRRREDEGRRRRRRRSRERRSDSEEERWQRSGMRSRSPPRPKWHSRDGSSQSDSGEEQSRGQWARRRRRARSWSPSSSASSSASPGRSQSPRAAAAALSQQQSLQERLRLREERKQQEELMKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFGDNNLLGTFIWNKALEKKGISHLEEKELKERNKRIQEDNRLELQKVKQLRLEREREKAMREQELEMLQREKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLYKLKQEQGVESEPLFPILKQEPQSPSRSLEPEDAAPTPPGPSSEGGPAEAEVDGATPTEGDGDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTAHELPLDAHVLEPDEDLQRLQLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVEMPLTGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Phosphorylation | RRQSQSGSRSRSRSH CCCCCCCCCHHCCHH | - | ||
| 52 | Phosphorylation | RRRRRRRSRERRSDS HHHHHHHHHHHHCCC | 29449344 | ||
| 57 | Phosphorylation | RRSRERRSDSEEERW HHHHHHHCCCHHHHH | 30576142 | ||
| 59 | Phosphorylation | SRERRSDSEEERWQR HHHHHCCCHHHHHHH | 30576142 | ||
| 71 (in isoform 2) | Phosphorylation | - | 21406692 | ||
| 71 | Phosphorylation | WQRSGMRSRSPPRPK HHHHCCCCCCCCCCC | 26055452 | ||
| 73 | Phosphorylation | RSGMRSRSPPRPKWH HHCCCCCCCCCCCCC | 28176443 | ||
| 81 | Phosphorylation | PPRPKWHSRDGSSQS CCCCCCCCCCCCCCC | 23909892 | ||
| 85 | Phosphorylation | KWHSRDGSSQSDSGE CCCCCCCCCCCCCCC | 25137130 | ||
| 86 | Phosphorylation | WHSRDGSSQSDSGEE CCCCCCCCCCCCCCC | 25137130 | ||
| 88 | Phosphorylation | SRDGSSQSDSGEEQS CCCCCCCCCCCCCHH | 25137130 | ||
| 90 | Phosphorylation | DGSSQSDSGEEQSRG CCCCCCCCCCCHHHH | 25137130 | ||
| 95 | Phosphorylation | SDSGEEQSRGQWARR CCCCCCHHHHHHHHH | 29449344 | ||
| 108 | Phosphorylation | RRRRRARSWSPSSSA HHHHHHHHCCCCCCC | 20873877 | ||
| 110 | Phosphorylation | RRRARSWSPSSSASS HHHHHHCCCCCCCCC | 24719451 | ||
| 112 | Phosphorylation | RARSWSPSSSASSSA HHHHCCCCCCCCCCC | 27134283 | ||
| 113 | Phosphorylation | ARSWSPSSSASSSAS HHHCCCCCCCCCCCC | 25022875 | ||
| 114 | Phosphorylation | RSWSPSSSASSSASP HHCCCCCCCCCCCCC | 22468782 | ||
| 116 | Phosphorylation | WSPSSSASSSASPGR CCCCCCCCCCCCCCC | 25022875 | ||
| 117 | Phosphorylation | SPSSSASSSASPGRS CCCCCCCCCCCCCCC | 25022875 | ||
| 118 | Phosphorylation | PSSSASSSASPGRSQ CCCCCCCCCCCCCCC | 25022875 | ||
| 120 | Phosphorylation | SSASSSASPGRSQSP CCCCCCCCCCCCCCH | 20873877 | ||
| 124 | Phosphorylation | SSASPGRSQSPRAAA CCCCCCCCCCHHHHH | 22817900 | ||
| 126 | Phosphorylation | ASPGRSQSPRAAAAA CCCCCCCCHHHHHHH | 22817900 | ||
| 135 | Phosphorylation | RAAAAALSQQQSLQE HHHHHHHHHHHHHHH | 29523821 | ||
| 139 | Phosphorylation | AALSQQQSLQERLRL HHHHHHHHHHHHHHH | 27251275 | ||
| 151 | "N6,N6-dimethyllysine" | LRLREERKQQEELMK HHHHHHHHHHHHHHH | - | ||
| 151 | Methylation | LRLREERKQQEELMK HHHHHHHHHHHHHHH | 23644510 | ||
| 158 | Methylation | KQQEELMKAFETPEE HHHHHHHHHHCCHHH | 23644510 | ||
| 158 | "N6,N6-dimethyllysine" | KQQEELMKAFETPEE HHHHHHHHHHCCHHH | - | ||
| 158 | Ubiquitination | KQQEELMKAFETPEE HHHHHHHHHHCCHHH | 29967540 | ||
| 162 | Phosphorylation | ELMKAFETPEEKRAR HHHHHHCCHHHHHHH | 21815630 | ||
| 166 | Ubiquitination | AFETPEEKRARRLAK HHCCHHHHHHHHHHH | 24816145 | ||
| 174 | Ubiquitination | RARRLAKKEAKERKK HHHHHHHHHHHHHHH | 24816145 | ||
| 219 | Ubiquitination | WNKALEKKGISHLEE HHHHHHHCCCCHHHH | 29967540 | ||
| 222 | Phosphorylation | ALEKKGISHLEEKEL HHHHCCCCHHHHHHH | 25159151 | ||
| 267 | Sulfoxidation | MREQELEMLQREKEA HHHHHHHHHHHHHHH | 21406390 | ||
| 293 | Ubiquitination | NFHLQQAKLRSKIRI CHHHHHHHHHHCCEE | 29967540 | ||
| 366 | Sulfoxidation | NADFWRDMTTITEDE CCCCHHHCCCCCHHH | 21406390 | ||
| 376 | Ubiquitination | ITEDEISKLRKLEAS CCHHHHHHHHHHHHC | 24816145 | ||
| 385 | Ubiquitination | RKLEASGKGPGERRE HHHHHCCCCCCCCCC | 24816145 | ||
| 397 | Phosphorylation | RREGVNASVSSDVQS CCCCCCCCCCCCHHH | 20068231 | ||
| 399 | Phosphorylation | EGVNASVSSDVQSVF CCCCCCCCCCHHHHH | 20068231 | ||
| 400 | Phosphorylation | GVNASVSSDVQSVFK CCCCCCCCCHHHHHC | 20068231 | ||
| 404 | Phosphorylation | SVSSDVQSVFKGKTY CCCCCHHHHHCCCCH | 20068231 | ||
| 409 | Ubiquitination | VQSVFKGKTYNQLQV HHHHHCCCCHHHHHH | - | ||
| 421 | Phosphorylation | LQVIFQGIEGKIRAG HHHHECCCCCEECCC | 15302935 | ||
| 424 | Ubiquitination | IFQGIEGKIRAGGPN HECCCCCEECCCCCC | - | ||
| 469 | Ubiquitination | RQKLYKLKQEQGVES HHHHHHHHHHHCCCC | 29967540 | ||
| 469 | Sumoylation | RQKLYKLKQEQGVES HHHHHHHHHHHCCCC | 28112733 | ||
| 476 | Phosphorylation | KQEQGVESEPLFPIL HHHHCCCCCCCCHHH | 28450419 | ||
| 484 | Sumoylation | EPLFPILKQEPQSPS CCCCHHHCCCCCCCC | 28112733 | ||
| 489 | Phosphorylation | ILKQEPQSPSRSLEP HHCCCCCCCCCCCCH | 23401153 | ||
| 491 | Phosphorylation | KQEPQSPSRSLEPED CCCCCCCCCCCCHHH | 23401153 | ||
| 493 | Phosphorylation | EPQSPSRSLEPEDAA CCCCCCCCCCHHHCC | 26074081 | ||
| 507 | Phosphorylation | APTPPGPSSEGGPAE CCCCCCCCCCCCCCE | 22468782 | ||
| 550 | Phosphorylation | EEDLIQQSLDDYDAG CHHHHHHCCCCCCCC | 24275569 | ||
| 554 | Phosphorylation | IQQSLDDYDAGRYSP HHHCCCCCCCCCCCC | 24275569 | ||
| 559 | Phosphorylation | DDYDAGRYSPRLLTA CCCCCCCCCCCCEEE | 28112733 | ||
| 560 | Phosphorylation | DYDAGRYSPRLLTAH CCCCCCCCCCCEEEC | 26074081 | ||
| 565 | Phosphorylation | RYSPRLLTAHELPLD CCCCCCEEECCCCCC | 26074081 | ||
| 588 | Phosphorylation | DLQRLQLSRQQLQVT HHHHHHHHHHHHHHH | - | ||
| 599 | Phosphorylation | LQVTGDASESAEDIF HHHHCCCCCCHHHHH | - | ||
| 601 | Phosphorylation | VTGDASESAEDIFFR HHCCCCCCHHHHHHH | - | ||
| 671 | Ubiquitination | DFDNPPPKIVQGYKF CCCCCCCCCCCEEEE | 29967540 | ||
| 677 | Acetylation | PKIVQGYKFNIFYPD CCCCCEEEEEEECHH | 25953088 | ||
| 722 | Acetylation | PYEDIAFKIVNREWE CHHHCCHHHHCCCCC | 25953088 | ||
| 920 (in isoform 2) | Phosphorylation | - | 27259358 | ||
| 928 (in isoform 2) | Phosphorylation | - | 27259358 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CATIN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CATIN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CATIN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRI39_HUMAN | TRIM39 | physical | 26363554 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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