DDX50_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX50_MOUSE
• UniProt AC: Q99MJ9
• Protein Name: ATP-dependent RNA helicase DDX50
• Gene Name: Ddx50
• Organism: Mus musculus (Mouse).
• Sequence Length: 734
• Subcellular Localization: Nucleus, nucleolus.
• Protein Sequence: MPGKLLWGDIMELEAPLEESESQRKERQKSDRRKSRHHSESEERTETRENGVTDDLDAPKPKKAKMREKLNGDTKEGLRFSDEFSPSHKSRRKDLPNGDVDEYEKRSKRVSSSENSHKSSDKAEETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSHVTRMCLLKGNMGVCFDVPTSESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNPRQRSGWSGGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRNFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	QKSDRRKSRHHSESE HHHHHHHHHHCCCHH	34.73	23684622
39	Phosphorylation	RRKSRHHSESEERTE HHHHHHCCCHHHHHH	36.37	26824392
41	Phosphorylation	KSRHHSESEERTETR HHHHCCCHHHHHHHH	48.01	26824392
45	Phosphorylation	HSESEERTETRENGV CCCHHHHHHHHHCCC	45.01	25266776
47	Phosphorylation	ESEERTETRENGVTD CHHHHHHHHHCCCCC	42.54	25777480
81	Phosphorylation	TKEGLRFSDEFSPSH CHHCCCCCCCCCCCC	29.78	25159016
85	Phosphorylation	LRFSDEFSPSHKSRR CCCCCCCCCCCCCCC	24.36	26824392
87	Phosphorylation	FSDEFSPSHKSRRKD CCCCCCCCCCCCCCC	42.20	25159016
111	Phosphorylation	EKRSKRVSSSENSHK HHHHHCCCCCCCCCC	31.98	24899341
112	Phosphorylation	KRSKRVSSSENSHKS HHHHCCCCCCCCCCC	38.52	-
113	Phosphorylation	RSKRVSSSENSHKSS HHHCCCCCCCCCCCC	33.04	-
119	Phosphorylation	SSENSHKSSDKAEET CCCCCCCCCHHHHHH	38.04	-
120	Phosphorylation	SENSHKSSDKAEETL CCCCCCCCHHHHHHH	48.19	-
244	Phosphorylation	VACFYGGTSYQSQIN HHHHCCCCCHHHHHH	21.65	-
263	Phosphorylation	GIDILVGTPGRIKDH CCCEEECCCCHHHHH	18.32	22817900
400	Phosphorylation	CETKKNVTEMAMNPH EEECCCHHHHHCCHH	29.45	26060331
429	Ubiquitination	SQREITLKGFREGSF HCCEEEEECCCCCCE	47.56	-
468	Phosphorylation	SPPQDVESYIHRSGR CCCCCHHHHHHHCCC	29.27	22817900
473	Phosphorylation	VESYIHRSGRTGRAG HHHHHHHCCCCCCCC	20.61	24453211
515	Phosphorylation	FKRVGVPSTMDLVKS EEECCCCCHHHHHHC	33.68	-
576	Phosphorylation	ASSFEPRSLITSDKG CCCCCCCHHCCCCCC	34.53	22817900
579	Phosphorylation	FEPRSLITSDKGFVT CCCCHHCCCCCCEEE	35.85	22817900
599	Phosphorylation	PEEIQDVSCAWKELN HHHHHHCHHHHHHHH	13.35	22817900
610	Phosphorylation	KELNRKLSSNAVSHV HHHHHHHHHHHHHHH	25.28	28507225
677	Phosphorylation	SSNPRQRSGWSGGRS CCCCCCCCCCCCCCC	35.95	24719451
680	Phosphorylation	PRQRSGWSGGRSGRS CCCCCCCCCCCCCCC	34.59	30635358
687	Phosphorylation	SGGRSGRSGRSGGRS CCCCCCCCCCCCCCC	41.92	24719451
690	Phosphorylation	RSGRSGRSGGRSGGR CCCCCCCCCCCCCCC	49.47	24719451
693	Methylation	RSGRSGGRSGGRSGR CCCCCCCCCCCCCCC	35.34	-
697	Methylation	SGGRSGGRSGRQSRQ CCCCCCCCCCCCCCC	39.19	-
707	Dimethylation	RQSRQGSRSGSRQDG CCCCCCCCCCCCCCC	52.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX50_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX50_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX50_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX50_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.