PEX1_MOUSE - dbPTM
PEX1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX1_MOUSE
UniProt AC Q5BL07
Protein Name Peroxisome biogenesis factor 1
Gene Name Pex1
Organism Mus musculus (Mouse).
Sequence Length 1284
Subcellular Localization Cytoplasm. Peroxisome membrane. Associated with peroxisomal membranes..
Protein Description Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity)..
Protein Sequence MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVASDHQPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVSCQQVEVEPLSADDWEILELHAISLEQHLLDQIRIVFPKAVVPIWVDQQTYIFIQIVTLMPAAPYGRLETNTKLLIQPKTRQAKESTFPKEGDAHGQVHSYGREQKGLSKELQTRQLHTNSEGITASNGRDPKVPGGPLKPSWWAVLGSMLSFGPDSKQESAWGSLELGAFKNMQSQAAPLEGTFRVCQVQPPSARTTTATSVFHKHCTAHVFPWDQEYFDVEPSFTVTYGKLVKLHSPKQQQDKSKQGVLLPDKEKQLSKSPDHKQISSNRSEEAAEACVLKVVWNGLEELKNATEFTESLELLHRGKVWIPDDLRKRLNIEMHAVVRITPLETTPKIPRSLKLQPRENLPKDVNEETIKTVFSSWVQQSATTMLPLVISKEERIKLEIKDGLREFSLSTVHSQEKEKEEGKTVFVLSSILLQKISVQVLLEPMIKEEQSAEIDFLLPSLTLSSLGGVSALGASAMEHITHSLLGRPLSRQLMALVAGLRNGALLITGGKGSGKSTFAKAICKEAQDTLDARVETVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSVPEQEHSPEAVQSQRLAHALNDMIKEFVSTGSLVALIATSQLQQSLHPSLVSAQGIHTFQCVQHLQPPNPEQRCEILHSVVKNKLGCDISNFPDLDLQCIAKDTEAFVARDFTVLVDRAIHSSLSRQHSSSREDLTLTTSDFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIKGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLALADDVDLQHVASVTDSFTGADLKALLYNAQLEALQGRLLPSGLPDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLEQSLLSLEMSEILPDESKFNMYRLYFGSSYESELGNGTPSDLSSHCLSAPSSVTQDLPAAPGKDPLFTQHPVFRTPSQEGCQDLTQEQRDQLRAEISIIKGRYRSQSGEDESLNQPGPIKTTFAISQAHLMTALAHTRPSISEDEGKEFAELYENFQNPKKRKNQSGTVFRTGQKVTLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
188UbiquitinationTRQAKESTFPKEGDA
CCCCHHCCCCCCCCC		45.0827667366
196UbiquitinationFPKEGDAHGQVHSYG
CCCCCCCCCCCCCCC		31.7727667366
201PhosphorylationDAHGQVHSYGREQKG
CCCCCCCCCCCHHCC		30.35-
201 (in isoform 2)Phosphorylation-30.3524719451
215PhosphorylationGLSKELQTRQLHTNS
CCCHHHHHCCCCCCC		32.7630635358
220PhosphorylationLQTRQLHTNSEGITA
HHHCCCCCCCCCCCC		49.3730635358
226PhosphorylationHTNSEGITASNGRDP
CCCCCCCCCCCCCCC		34.5830635358
228PhosphorylationNSEGITASNGRDPKV
CCCCCCCCCCCCCCC		31.0330635358
234AcetylationASNGRDPKVPGGPLK
CCCCCCCCCCCCCCC		66.4122902405
342UbiquitinationVKLHSPKQQQDKSKQ
EEECCCCCCCCCCCC		49.9427667366
348UbiquitinationKQQQDKSKQGVLLPD
CCCCCCCCCCCCCCH		57.7322790023
356UbiquitinationQGVLLPDKEKQLSKS
CCCCCCHHHHHHCCC		65.9422790023
361PhosphorylationPDKEKQLSKSPDHKQ
CHHHHHHCCCCCHHH		28.7023140645
363PhosphorylationKEKQLSKSPDHKQIS
HHHHHCCCCCHHHCC		31.9823140645
410UbiquitinationLELLHRGKVWIPDDL
HHHHHCCCEECCHHH		34.0622790023
454UbiquitinationQPRENLPKDVNEETI
CCCCCCCCCCCHHHH		76.9722790023
460PhosphorylationPKDVNEETIKTVFSS
CCCCCHHHHHHHHHH		22.9222802335
474PhosphorylationSWVQQSATTMLPLVI
HHHHHCHHHEEEEEE		20.2722802335
475PhosphorylationWVQQSATTMLPLVIS
HHHHCHHHEEEEEEC		19.2122802335
482PhosphorylationTMLPLVISKEERIKL
HEEEEEECHHHHEEE		26.9122802335
615UbiquitinationTFAKAICKEAQDTLD
HHHHHHHHHHHHHHH		50.3922790023
631UbiquitinationRVETVDCKALRGKRL
CEEECCHHHHCCCHH		46.0922790023
640PhosphorylationLRGKRLESIQKALEV
HCCCHHHHHHHHHHH		34.61-
657UbiquitinationSEAAWRQPSVILLDD
HHHHHCCCCEEEECC		23.2227667366
777UbiquitinationLQCIAKDTEAFVARD
HHHEECCCHHHHHCC		28.6227667366
817UbiquitinationLTTSDFQKALRGFLP
EEHHHHHHHHHCCCC		49.7522790023
842UbiquitinationPRDLGWDKIGGLHEV
CCCCCCCCCCCHHHH		36.4222790023
881PhosphorylationQRTGILLYGPPGTGK
CCCEEEEECCCCCCH		24.9222817900
914UbiquitinationKGPELLSKYIGASEQ
ECHHHHHHHCCCCHH		40.6422790023
1115PhosphorylationSLLSLEMSEILPDES
HHHHHHHHHHCCCCH		16.47-
1122PhosphorylationSEILPDESKFNMYRL
HHHCCCCHHHCEEEE		50.34-
1127PhosphorylationDESKFNMYRLYFGSS
CCHHHCEEEEECCCC		9.89-
1170 (in isoform 2)Phosphorylation-32.6224719451
1180PhosphorylationTQHPVFRTPSQEGCQ
CCCCCCCCCCCCCHH		18.8127087446
1182PhosphorylationHPVFRTPSQEGCQDL
CCCCCCCCCCCHHCC		40.0125521595
1190PhosphorylationQEGCQDLTQEQRDQL
CCCHHCCCHHHHHHH		38.0530635358
1208PhosphorylationISIIKGRYRSQSGED
HHEEECCCCCCCCCC		24.2429895711
1210PhosphorylationIIKGRYRSQSGEDES
EEECCCCCCCCCCCC		21.5525521595
1212PhosphorylationKGRYRSQSGEDESLN
ECCCCCCCCCCCCCC		45.4527087446
1217PhosphorylationSQSGEDESLNQPGPI
CCCCCCCCCCCCCCC		44.9625521595
1268MalonylationFQNPKKRKNQSGTVF
CCCCCCCCCCCCCCE		69.1226320211
1271PhosphorylationPKKRKNQSGTVFRTG
CCCCCCCCCCCEECC		45.9123684622
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEX1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PEX1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1212, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1212, AND MASSSPECTROMETRY.

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