SH3B4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3B4_MOUSE
• UniProt AC: Q921I6
• Protein Name: SH3 domain-binding protein 4
• Gene Name: Sh3bp4
• Organism: Mus musculus (Mouse).
• Sequence Length: 962
• Subcellular Localization: Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity)..
• Protein Description: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity)..
• Protein Sequence: MAAQRIRAANASGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPEEVAKELDLLGGGWTDDQKESGRPYSNNPFWNGVRTNPFLNGNAQPSTDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELPATNGLQVEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPVPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSVSPVVEVKLSNLEVSTFIILEMKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYVPIPLAYSYGDTIQVQLDNLEPCMYLAIVAQGPNILYPSTVWDFINKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYEVKANEQARVVRGFQMKLGKVSRLIFSVISQNPNELSDFTLRVQVKDDQDTILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVVALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVASVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Methylation	-MAAQRIRAANASGL -CHHHHHHHHHCCCC	29.81	16189187
19	Phosphorylation	SGLPRCKSEGTLIDL CCCCCCCCCCCEEEC	44.90	18846507
22	Phosphorylation	PRCKSEGTLIDLSEG CCCCCCCCEEECCCC	19.25	27087446
42	Phosphorylation	FNDVKVPSPSALLVD CCCCCCCCCCEEEEC	34.18	26824392
44	Phosphorylation	DVKVPSPSALLVDNP CCCCCCCCEEEECCC	35.57	28418008
117	Phosphorylation	QPLNYRNSTLSDSGM CCCCCCCCCCCCCCC	23.02	21743459
118	Phosphorylation	PLNYRNSTLSDSGMI CCCCCCCCCCCCCCC	33.55	21743459
120	Phosphorylation	NYRNSTLSDSGMIDN CCCCCCCCCCCCCCC	29.80	21743459
122	Phosphorylation	RNSTLSDSGMIDNLP CCCCCCCCCCCCCCC	27.21	21743459
131	Phosphorylation	MIDNLPDSPEEVAKE CCCCCCCCHHHHHHH	32.07	27180971
153	Phosphorylation	WTDDQKESGRPYSNN CCCCCCCCCCCCCCC	47.33	29514104
158	Phosphorylation	KESGRPYSNNPFWNG CCCCCCCCCCCCCCC	32.58	29514104
240	Phosphorylation	RDNPFFRSKRSYSLS CCCHHHCCCCCEEHH	27.54	26824392
243	Phosphorylation	PFFRSKRSYSLSELS HHHCCCCCEEHHHHH	23.86	27087446
244	Phosphorylation	FFRSKRSYSLSELSV HHCCCCCEEHHHHHH	20.05	26239621
245	Phosphorylation	FRSKRSYSLSELSVL HCCCCCEEHHHHHHH	27.02	25521595
247	Phosphorylation	SKRSYSLSELSVLQA CCCCEEHHHHHHHHH	30.47	26239621
250	Phosphorylation	SYSLSELSVLQAKSD CEEHHHHHHHHHCCC	19.41	26824392
261	Phosphorylation	AKSDAPPTSSFFTGL HCCCCCCCCHHHCCC	35.62	23984901
262	Phosphorylation	KSDAPPTSSFFTGLK CCCCCCCCHHHCCCC	30.81	23984901
263	Phosphorylation	SDAPPTSSFFTGLKS CCCCCCCHHHCCCCC	27.19	23984901
266	Phosphorylation	PPTSSFFTGLKSPVP CCCCHHHCCCCCCCC	39.32	23984901
270	Phosphorylation	SFFTGLKSPVPEQFQ HHHCCCCCCCCHHHC	35.85	23984901
278	Phosphorylation	PVPEQFQSREDFRTA CCCHHHCCCHHHHHH	38.64	26824392
295	Phosphorylation	NHRKLARSCHDLDLL HHHHHHHHCCCCHHC	15.36	27087446
305	Phosphorylation	DLDLLGQSPGWGQTQ CCHHCCCCCCCCCCC	24.47	23984901
311	Phosphorylation	QSPGWGQTQAVETNI CCCCCCCCCEEEEEE	17.98	25168779
316	Phosphorylation	GQTQAVETNIVCKLD CCCCEEEEEEEEEEC	24.52	25168779
636	Phosphorylation	EVGKIILSPFVVTTK CCCCEEECCEEEECC	13.09	26824392
646	Phosphorylation	VVTTKYPTFQDRPVS EEECCCCCCCCCCCH	30.73	25521595
653	Phosphorylation	TFQDRPVSSLKFGKL CCCCCCCHHHCHHHH	32.41	25521595
654	Phosphorylation	FQDRPVSSLKFGKLL CCCCCCHHHCHHHHH	35.49	25521595
876	Phosphorylation	QQMDAYESPHRDRNG HHHHHHHCCCCCCCC	17.21	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
245	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3B4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3B4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SH3B4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.