CLK3_MOUSE - dbPTM
CLK3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLK3_MOUSE
UniProt AC O35492
Protein Name Dual specificity protein kinase CLK3
Gene Name Clk3
Organism Mus musculus (Mouse).
Sequence Length 638
Subcellular Localization Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein Description Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells..
Protein Sequence MPVLSARRKRLASTAGPRRGSGPSLAVRWVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGAGRGPRLLPGPPGRDLHRCRPDPGGAGQSPRVCEFGARAVRPLGRVEPGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationARRKRLASTAGPRRG
HHHHHHHHCCCCCCC		24.3129514104
14PhosphorylationRRKRLASTAGPRRGS
HHHHHHHCCCCCCCC		29.9922942356
21PhosphorylationTAGPRRGSGPSLAVR
CCCCCCCCCCCCEEE		45.8029176673
24PhosphorylationPRRGSGPSLAVRWVP
CCCCCCCCCEEEECC		32.2729176673
88PhosphorylationDPGGAGQSPRVCEFG
CCCCCCCCCCCCCCC		17.4727600695
155PhosphorylationTMHHCKRYRSPEPDP
HHHHHHHCCCCCCCC		10.8421082442
157PhosphorylationHHCKRYRSPEPDPYL
HHHHHCCCCCCCCCH		25.3626824392
163PhosphorylationRSPEPDPYLSYRWKR
CCCCCCCCHHHHHHC		18.7028833060
165PhosphorylationPEPDPYLSYRWKRRR
CCCCCCHHHHHHCCC		13.5526643407
166PhosphorylationEPDPYLSYRWKRRRS
CCCCCHHHHHHCCCC		20.2125266776
173PhosphorylationYRWKRRRSYSREHEG
HHHHCCCCCCCCCCC		26.1622324799
174PhosphorylationRWKRRRSYSREHEGR
HHHCCCCCCCCCCCC		15.2223737553
175PhosphorylationWKRRRSYSREHEGRL
HHCCCCCCCCCCCCC		32.2223737553
197PhosphorylationPPPRRSRSRSHDRIP
CCCCCCCCCCCCCCC		39.1125159016
199PhosphorylationPRRSRSRSHDRIPYQ
CCCCCCCCCCCCCHH		30.8725159016
205PhosphorylationRSHDRIPYQRRYREH
CCCCCCCHHHHHHHH		16.5725367039
215PhosphorylationRYREHRDSDTYRCEE
HHHHHCCCCCCCCCC		31.6325159016
217PhosphorylationREHRDSDTYRCEERS
HHHCCCCCCCCCCCC		19.4725159016
218PhosphorylationEHRDSDTYRCEERSP
HHCCCCCCCCCCCCC		20.4627600695
224PhosphorylationTYRCEERSPSFGEDC
CCCCCCCCCCCCCCC		28.3325521595
226PhosphorylationRCEERSPSFGEDCYG
CCCCCCCCCCCCCCC		47.3225521595
232PhosphorylationPSFGEDCYGSSRSRH
CCCCCCCCCCCHHHH		32.1529899451
234PhosphorylationFGEDCYGSSRSRHRR
CCCCCCCCCHHHHHH		8.9825159016
235PhosphorylationGEDCYGSSRSRHRRR
CCCCCCCCHHHHHHH		29.8829899451
280PhosphorylationSQQSSKRSSRSVEDD
HHHCCCCCCCCCCCC		33.5628418008
281PhosphorylationQQSSKRSSRSVEDDK
HHCCCCCCCCCCCCC		32.3823684622
283PhosphorylationSSKRSSRSVEDDKEG
CCCCCCCCCCCCCCC		31.6326824392
462PhosphorylationEEKSVKNTSIRVADF
HHHCCCCCEEEEEEC		21.5825619855
637PhosphorylationFHSSRNPSR------
HHHCCCCCC------		54.9229514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLK3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLK3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLK3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLK3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLK3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-155, AND MASSSPECTROMETRY.

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