MYL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYL3_MOUSE
• UniProt AC: P09542
• Protein Name: Myosin light chain 3 {ECO:0000305}
• Gene Name: Myl3 {ECO:0000312|MGI:MGI:97268}
• Organism: Mus musculus (Mouse).
• Sequence Length: 204
• Protein Description: Regulatory light chain of myosin. Does not bind calcium..
• Protein Sequence: MAPKKPEPKKDDAKAAAPKAAPAPAAAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFLLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MAPKKPEPK ------CCCCCCCCC	25.31	20668449
19	Ubiquitination	DAKAAAPKAAPAPAA CHHHHCCCCCCCCCC	53.07	22790023
42	Ubiquitination	APEPERPKEAEFDAS CCCCCCCCCCCCCHH	75.64	22790023
49	Phosphorylation	KEAEFDASKIKIEFT CCCCCCHHHCEEEEC	36.44	27742792
50	Ubiquitination	EAEFDASKIKIEFTP CCCCCHHHCEEEECH	50.14	22790023
52	Ubiquitination	EFDASKIKIEFTPEQ CCCHHHCEEEECHHH	39.66	22790023
73	Phosphorylation	AFLLFDRTPKGEMKI HHHCCCCCCCCCCEE	31.06	-
75	Ubiquitination	LLFDRTPKGEMKITY HCCCCCCCCCCEEEE	67.88	22790023
79	Ubiquitination	RTPKGEMKITYGQCG CCCCCCCEEEEECHH	27.82	22790023
81	Phosphorylation	PKGEMKITYGQCGDV CCCCCEEEEECHHHH	18.97	-
82	Phosphorylation	KGEMKITYGQCGDVL CCCCEEEEECHHHHH	14.52	-
85	S-nitrosocysteine	MKITYGQCGDVLRAL CEEEEECHHHHHHHC	4.34	-
85	S-nitrosylation	MKITYGQCGDVLRAL CEEEEECHHHHHHHC	4.34	21278135
97	Phosphorylation	RALGQNPTQAEVLRV HHCCCCCCHHHHHHH	48.22	-
107	Ubiquitination	EVLRVLGKPKQEELN HHHHHHCCCCHHHHH	44.90	22790023
109	Ubiquitination	LRVLGKPKQEELNSK HHHHCCCCHHHHHHH	74.05	22790023
109	Acetylation	LRVLGKPKQEELNSK HHHHCCCCHHHHHHH	74.05	21728379
132	Ubiquitination	PMLQHISKNKDTGTY HHHHHHHCCCCCCCH	68.37	22790023
134	Ubiquitination	LQHISKNKDTGTYED HHHHHCCCCCCCHHH	61.47	22790023
136	Phosphorylation	HISKNKDTGTYEDFV HHHCCCCCCCHHHHH	32.79	23737553
138	Phosphorylation	SKNKDTGTYEDFVEG HCCCCCCCHHHHHHH	26.32	23737553
139	Phosphorylation	KNKDTGTYEDFVEGL CCCCCCCHHHHHHHE	18.17	23737553
151	Acetylation	EGLRVFDKEGNGTVM HHEEEEEECCCCEEE	56.93	55169713
151	Ubiquitination	EGLRVFDKEGNGTVM HHEEEEEECCCCEEE	56.93	22790023
180	Ubiquitination	LTEDEVEKLMAGQED CCHHHHHHHHCCCCC	49.06	22790023
188	Phosphorylation	LMAGQEDSNGCINYE HHCCCCCCCCCCCHH	34.08	23737553
191	S-nitrosocysteine	GQEDSNGCINYEAFV CCCCCCCCCCHHHHH	1.82	-
191	S-nitrosylation	GQEDSNGCINYEAFV CCCCCCCCCCHHHHH	1.82	21278135
194	Phosphorylation	DSNGCINYEAFVKHI CCCCCCCHHHHHHHH	6.68	27742792
199	Ubiquitination	INYEAFVKHIMAS-- CCHHHHHHHHHCC--	22.44	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Methylation

"NRMT is an alpha-N-methyltransferase that methylates RCC1 andretinoblastoma protein.";
Tooley C.E., Petkowski J.J., Muratore-Schroeder T.L., Balsbaugh J.L.,Shabanowitz J., Sabat M., Minor W., Hunt D.F., Macara I.G.;
Nature 466:1125-1128(2010).
Cited for: CLEAVAGE OF INITIATOR METHIONINE, AND METHYLATION AT ALA-2.
PubMed: 20668449