EZH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EZH1_MOUSE
• UniProt AC: P70351
• Protein Name: Histone-lysine N-methyltransferase EZH1
• Gene Name: Ezh1
• Organism: Mus musculus (Mouse).
• Sequence Length: 747
• Subcellular Localization: Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3..
• Protein Description: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation..
• Protein Sequence: MDIASPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQPMKPVSGHPFLKKCTIESIFPGFDSQDMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEDGHNDPSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNASASAMAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPAQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPAQKKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCSPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Methylation	DSQDMLMRSLNTVAL CHHHHHHHHHCHHHH	33.75	-
257	Phosphorylation	PDDMKERYRELTEMS CCHHHHHHHHHHHCC	14.99	29899451
261	Phosphorylation	KERYRELTEMSDPNA HHHHHHHHHCCCCCC	25.53	29899451
388	Phosphorylation	AETKEGDSDRDTGND HHCCCCCCCCCCCCC	45.46	26643407
392	Phosphorylation	EGDSDRDTGNDWASS CCCCCCCCCCCCCCC	38.49	26643407
416	Phosphorylation	TPTKQKASPAPAQLC CCCCCCCCCCCCEEE	28.73	25195567

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EZH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EZH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EZH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EED_MOUSE	Eed	physical	20064376
SUZ12_MOUSE	Suz12	physical	20064376
RBBP4_MOUSE	Rbbp4	physical	20064376
AEBP2_MOUSE	Aebp2	physical	20064376
JARD2_MOUSE	Jarid2	physical	20064376
MTF2_MOUSE	Mtf2	physical	20064376
STK38_MOUSE	Stk38	physical	20064376
RBBP4_MOUSE	Rbbp4	physical	25680957
SUZ12_MOUSE	Suz12	physical	25680957
EZH1_MOUSE	Ezh1	physical	25680957
JARD2_MOUSE	Jarid2	physical	25680957
EPOP_MOUSE	E130012A19Rik	physical	25680957
MTF2_MOUSE	Mtf2	physical	25680957
EED_MOUSE	Eed	physical	25680957
RBBP7_MOUSE	Rbbp7	physical	25680957
AEBP2_MOUSE	Aebp2	physical	25680957
EHMT2_MOUSE	Ehmt2	physical	25680957
WIZ_MOUSE	Wiz	physical	25680957
EHMT1_MOUSE	Ehmt1	physical	25680957
LRRF2_MOUSE	Lrrfip2	physical	25680957

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.