EPOP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPOP_MOUSE
• UniProt AC: Q7TNS8
• Protein Name: Elongin BC and Polycomb repressive complex 2-associated protein {ECO:0000303|PubMed:27863225, ECO:0000303|PubMed:27863226}
• Gene Name: Epop {ECO:0000303|PubMed:27863225, ECO:0000303|PubMed:27863226, ECO:0000312|MGI:MGI:2143991}
• Organism: Mus musculus (Mouse).
• Sequence Length: 369
• Subcellular Localization: Nucleus . Chromosome . Localizes at both PRC2/EED-EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs) (PubMed:27863226).
• Protein Description: Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). [PubMed: 27863225]
• Protein Sequence: METLCPPPRLAVPASPRGSPCSPTPLKPRRGTPEFSPLCLRALAFCALAKPRPSSLGLGPGELAPRTPVLLGPPASPCTGGWAADGLKHLGGQAGRPSDVSSPAREDADVAVCPGGGEEEEGGGGFPHFGAGSCAPPGRCPAPLRPQDSPTNPAWSPPRPARGLDAASSPPLEPGSPPPSPPAGLSPEPAPSEQPVPASEAPGGGDPAPTAPEAPALSPSTADAAPDPPRDLRQEHFNRLIRRSKLWCYAKGFALDTPSLRRGPERPAAKARGAAKKRRRPAPPPPSVQPRRPVPTLPTSSTFSLLDCFPCPPALVVEENGDLGPASSLRLQGDAKPPPAHPLWKWQMGGPAVPEPPGLKSWWVNLEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PRLAVPASPRGSPCS CCCCCCCCCCCCCCC		22006019
19	Phosphorylation	VPASPRGSPCSPTPL CCCCCCCCCCCCCCC		-
22	Phosphorylation	SPRGSPCSPTPLKPR CCCCCCCCCCCCCCC		25266776
52	Asymmetric dimethylarginine	FCALAKPRPSSLGLG HHHHHCCCCHHHCCC		-
52	Methylation	FCALAKPRPSSLGLG HHHHHCCCCHHHCCC		-
76	Phosphorylation	VLLGPPASPCTGGWA EEECCCCCCCCCCHH		24759943
102	Phosphorylation	GRPSDVSSPAREDAD CCCCCCCCCCCCCCC		23384938
156	Phosphorylation	SPTNPAWSPPRPARG CCCCCCCCCCCCCCC		25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPOP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPOP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPOP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BTF3_MOUSE	Btf3	physical	23180766
CPSF6_MOUSE	Cpsf6	physical	23180766
EED_MOUSE	Eed	physical	23180766
H12_MOUSE	Hist1h1c	physical	23180766
HS90A_MOUSE	Hsp90aa1	physical	23180766
INT3_MOUSE	Ints3	physical	23180766
KPRA_MOUSE	Prpsap1	physical	23180766
ML12B_MOUSE	Myl12b	physical	23180766
MTF2_MOUSE	Mtf2	physical	23180766
MYH9_MOUSE	Myh9	physical	23180766
NEK9_MOUSE	Nek9	physical	23180766
NKTR_MOUSE	Nktr	physical	23180766
PCNA_MOUSE	Pcna	physical	23180766
RBBP4_MOUSE	Rbbp4	physical	23180766
RL23A_MOUSE	Rpl23a	physical	23180766
RL28_MOUSE	Rpl28	physical	23180766
RS11_MOUSE	Rps11	physical	23180766
RS13_MOUSE	Rps13	physical	23180766
SETX_MOUSE	Setx	physical	23180766
SPTB2_MOUSE	Sptbn1	physical	23180766
SUZ12_MOUSE	Suz12	physical	23180766
T2EB_MOUSE	Gtf2e2	physical	23180766
THOC4_MOUSE	Alyref	physical	23180766
RS27A_MOUSE	Rps27a	physical	23180766

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.