SUZ12_MOUSE - dbPTM
SUZ12_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SUZ12_MOUSE
UniProt AC Q80U70
Protein Name Polycomb protein Suz12
Gene Name Suz12
Organism Mus musculus (Mouse).
Sequence Length 741
Subcellular Localization Nucleus . Chromosome . Localizes to the inactive X chromosome in trophoblast stem cells.
Protein Description Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8..
Protein Sequence MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAASGGKSGGGGCGGGGSYSASSSSAAAAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTSIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESATPSNEEIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationGSGPSAGSGGGGFGG
CCCCCCCCCCCCCCH		33.70-
202PhosphorylationHKKRKDVSCPIRQVP
HHCCCCCCCCCCCCC		25.0621454597
272PhosphorylationNGMINGETNENIDVS
CCEECCCCCCCCCCC		49.5925367039
279PhosphorylationTNENIDVSEELPARR
CCCCCCCCCCCCHHH		22.9325367039
343AcetylationWETILDGKRLPPFET
HHHHHCCCCCCCCCC		50.8990799
343UbiquitinationWETILDGKRLPPFET
HHHHHCCCCCCCCCC		50.89-
377UbiquitinationKSTAPVAKPLATRNS
CCCCCCCCCCCCCCC		40.5822790023
384PhosphorylationKPLATRNSESLHQEN
CCCCCCCCHHHCCCC		25.8528066266
386PhosphorylationLATRNSESLHQENKP
CCCCCCHHHCCCCCC		30.8528066266
538PhosphorylationLVCRPKRTKASMSEF
EEECCCCCCCHHHHH		36.7724759943
541PhosphorylationRPKRTKASMSEFLES
CCCCCCCHHHHHHHC		25.1323984901
543PhosphorylationKRTKASMSEFLESED
CCCCCHHHHHHHCCC		23.7722942356
548PhosphorylationSMSEFLESEDGEVEQ
HHHHHHHCCCCCEEE		43.0427087446
560PhosphorylationVEQQRTYSSGHNRLY
EEEEEEECCCCCEEE		29.2727841257
567PhosphorylationSSGHNRLYFHSDTCL
CCCCCEEEEECCCEE		8.9423984901
570PhosphorylationHNRLYFHSDTCLPLR
CCEEEEECCCEEECC		25.3923984901
572PhosphorylationRLYFHSDTCLPLRPQ
EEEEECCCEEECCCC		20.9626643407
585PhosphorylationPQEMEVDSEDEKDPE
CCCCCCCCCCCCCHH		52.7227087446
598PhosphorylationPEWLREKTITQIEEF
HHHHHHHHHHEEHHH		25.2221454597
606PhosphorylationITQIEEFSDVNEGEK
HHEEHHHCCCCHHHH		43.8821454597
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SUZ12_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SUZ12_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SUZ12_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JARD2_MOUSEJarid2physical
20064375
EZH2_MOUSEEzh2physical
20064375
EED_MOUSEEedphysical
20064375
JARD2_MOUSEJarid2physical
20064376
EZH2_MOUSEEzh2physical
22438827
EED_MOUSEEedphysical
22438827
EZH1_MOUSEEzh1physical
22438827
RBBP4_MOUSERbbp4physical
22438827
RBBP7_MOUSERbbp7physical
22438827
PHF19_MOUSEPhf19physical
22438827
MTF2_MOUSEMtf2physical
22438827
JARD2_MOUSEJarid2physical
22438827
AEBP2_MOUSEAebp2physical
22438827
EPOP_MOUSEE130012A19Rikphysical
22438827
EED_MOUSEEedphysical
24040135
EZH2_MOUSEEzh2physical
24040135
JARD2_MOUSEJarid2physical
23333148
RBBP4_MOUSERbbp4physical
25680957
SUZ12_MOUSESuz12physical
25680957
EZH2_MOUSEEzh2physical
25680957
EPOP_MOUSEE130012A19Rikphysical
25680957
JARD2_MOUSEJarid2physical
25680957
EED_MOUSEEedphysical
25680957
MTF2_MOUSEMtf2physical
25680957
AEBP2_MOUSEAebp2physical
25680957
RBBP7_MOUSERbbp7physical
25680957
DREB_MOUSEDbn1physical
25680957
DNM3B_MOUSEDnmt3bphysical
25680957
SMC5_MOUSESmc5physical
25680957
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SUZ12_MOUSE

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Related Literatures of Post-Translational Modification

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