PHF19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHF19_MOUSE
• UniProt AC: Q9CXG9
• Protein Name: PHD finger protein 19
• Gene Name: Phf19
• Organism: Mus musculus (Mouse).
• Sequence Length: 578
• Subcellular Localization: Nucleus .
• Protein Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2)..
• Protein Sequence: METQALEPGTLEAFGATSPNKGGLSKTKKNFKDLMSKVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLLTHWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLALYNLGVQSKKRYFDFEEILAFVNHHWELLQLGKLTSTPMTERGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPAPPGKLLPDRALMPSDKGTSELLRKKGKSKPGLLPQEPQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTDHHLASIFDFTLDEIQSLKSGSSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLTAKVHRPLRAKQRAAELEGRCASDSNAEGAVGPEQPDEGIDSHTLESISGDDSSLSHLKSSITNYFGAAGRLACGEKYRVLARRVTPEGKVQYLLEWEGTTPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METQALEPGT -----CCCCCCCCCC	20.17	25266776
10	Phosphorylation	TQALEPGTLEAFGAT CCCCCCCCCCCCCCC	31.94	24759943
17	Phosphorylation	TLEAFGATSPNKGGL CCCCCCCCCCCCCCC	45.13	24759943
18	Phosphorylation	LEAFGATSPNKGGLS CCCCCCCCCCCCCCC	26.41	25266776
25	Phosphorylation	SPNKGGLSKTKKNFK CCCCCCCCCCHHHHH	41.37	24759943
185	Phosphorylation	PEELDWDSPHRTNQQ HHHCCCCCCCCCCCC	20.53	-
363	Phosphorylation	MPSDKGTSELLRKKG CCCCCCHHHHHHHHC	34.61	-
433	Phosphorylation	DEIQSLKSGSSGQTF HHHHHHHCCCCCCCE	49.56	25777480
435	Phosphorylation	IQSLKSGSSGQTFFS HHHHHCCCCCCCEEC	38.08	25777480
436	Phosphorylation	QSLKSGSSGQTFFSD HHHHCCCCCCCEECC	38.14	25777480
439	Phosphorylation	KSGSSGQTFFSDVDS HCCCCCCCEECCCCC	30.12	25777480
442	Phosphorylation	SSGQTFFSDVDSTDA CCCCCEECCCCCCCC	32.31	25777480
446	Phosphorylation	TFFSDVDSTDAASTS CEECCCCCCCCCCCC	28.21	25777480
447	Phosphorylation	FFSDVDSTDAASTSG EECCCCCCCCCCCCC	25.79	25777480
451	Phosphorylation	VDSTDAASTSGSAST CCCCCCCCCCCCCCC	25.48	25777480
452	Phosphorylation	DSTDAASTSGSASTS CCCCCCCCCCCCCCC	32.17	25777480
453	Phosphorylation	STDAASTSGSASTSL CCCCCCCCCCCCCCC	28.40	25777480
455	Phosphorylation	DAASTSGSASTSLSY CCCCCCCCCCCCCCC	20.86	25777480
457	Phosphorylation	ASTSGSASTSLSYDS CCCCCCCCCCCCCCC	21.89	25777480
458	Phosphorylation	STSGSASTSLSYDSR CCCCCCCCCCCCCCC	33.14	25777480
459	Phosphorylation	TSGSASTSLSYDSRW CCCCCCCCCCCCCCC	16.90	25777480
461	Phosphorylation	GSASTSLSYDSRWTV CCCCCCCCCCCCCCC	27.02	25777480
462	Phosphorylation	SASTSLSYDSRWTVG CCCCCCCCCCCCCCC	24.19	25777480
464	Phosphorylation	STSLSYDSRWTVGSR CCCCCCCCCCCCCCC	22.83	25777480
470	Phosphorylation	DSRWTVGSRKRKLTA CCCCCCCCCCCCCHH	30.23	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHF19_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHF19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHF19_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUZ12_MOUSE	Suz12	physical	22438827
EZH2_MOUSE	Ezh2	physical	22438827
EED_MOUSE	Eed	physical	22438827
EED_MOUSE	Eed	physical	23104054
EZH2_MOUSE	Ezh2	physical	23104054
SUZ12_MOUSE	Suz12	physical	23104054

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.