dbPTM

KPRA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KPRA_MOUSE
UniProt AC	Q9D0M1
Protein Name	Phosphoribosyl pyrophosphate synthase-associated protein 1
Gene Name	Prpsap1
Organism	Mus musculus (Mouse).
Sequence Length	356
Subcellular Localization
Protein Description	Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis..
Protein Sequence	MNAARTGYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESPIDEVVVTNTVPHELQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNITVDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNAARTGY -------CCCCCCCE	7.50	-
24	Ubiquitination	AACTELAKRITERLG HHHHHHHHHHHHHHC	57.89	-
40	Phosphorylation	ELGKSVVYQETNGET HHCCEEEEECCCCCE	9.85	-
52	Ubiquitination	GETRVEIKESVRGQD CCEEEEEEHHHCCCE	30.36	-
103	Ubiquitination	IPYFPYSKQSKMRKR ECCCCCCCCHHHHHH	53.39	-
116	Acetylation	KRGSIVCKLLASMLA HHHHHHHHHHHHHHH	35.32	22826441
177	Phosphorylation	NAVIVAKSPDAAKRA CEEEEECCHHHHHHH	20.48	26824392
186	Phosphorylation	DAAKRAQSYAERLRL HHHHHHHHHHHHHHH	25.89	29899451
205	Phosphorylation	IHGEAQCTELDMDDG ECCCCEEEECCCCCC	27.74	26745281
215	Phosphorylation	DMDDGRHSPPMVKNA CCCCCCCCCCCCCCC	29.36	25521595
238	Ubiquitination	PLMMAKEKPPITVVG HHEECCCCCCEEEEE	56.22	-
281	Phosphorylation	ERGAYKIYVMATHGI HCCCEEEEEEEECCC	4.68	21183079
317	Ubiquitination	TVPHELQKLQCPKIK CCCHHHHHCCCCCCC	53.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KPRA_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KPRA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KPRA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KPRA_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KPRA_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, AND MASSSPECTROMETRY.	17242355 [Abstract]