SETX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SETX_MOUSE
• UniProt AC: A2AKX3
• Protein Name: Probable helicase senataxin {ECO:0000305}
• Gene Name: Setx {ECO:0000312|MGI:MGI:2443480}
• Organism: Mus musculus (Mouse).
• Sequence Length: 2646
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Cytoplasm . Chromosome . Chromosome, telomere . Cell projection, axon . Cell projection, growth cone . Most abundant in the nucleus (By similarity). Detected in granules (By similarity). Colocaliz
• Protein Description: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. [PubMed: 22767893 Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (By similarity Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI)]
• Protein Sequence: MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEAEDDDDLYIVDNNGEEQLFDCSGQDFENKLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNFNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Phosphorylation	EEQLFDCSGQDFENK CCCEEECCCCCCCCC	41.14	22817900
207	Phosphorylation	IELGLLESPDIYTSS HHHHHCCCCCCCCHH	28.04	26745281
211	Phosphorylation	LLESPDIYTSSVLEK HCCCCCCCCHHHHHC	14.14	26745281
317	Phosphorylation	DPIEAFQTIINNESY CHHHHHHHHHCCCCH	19.85	22802335
324	Phosphorylation	TIINNESYNREIQNI HHHCCCCHHHHHHHH	16.44	22802335
351	Phosphorylation	PHFDDMVTCSQIVYN CCCCCCEEEHHHHEE	10.37	21183079
353	Phosphorylation	FDDMVTCSQIVYNFN CCCCEEEHHHHEECC	17.36	22817900
602	Phosphorylation	IKFKMPQYSTFGDST CCCCCCCCCCCCCCC	12.10	27149854
603	Phosphorylation	KFKMPQYSTFGDSTS CCCCCCCCCCCCCCC	16.41	27149854
604	Phosphorylation	FKMPQYSTFGDSTST CCCCCCCCCCCCCCC	27.06	27149854
608	Phosphorylation	QYSTFGDSTSTFKTP CCCCCCCCCCCCCCC	25.33	27149854
609	Phosphorylation	YSTFGDSTSTFKTPP CCCCCCCCCCCCCCC	36.20	27149854
610	Phosphorylation	STFGDSTSTFKTPPS CCCCCCCCCCCCCCC	35.48	27149854
611	Phosphorylation	TFGDSTSTFKTPPSF CCCCCCCCCCCCCCH	29.28	27149854
628	Ubiquitination	ESDKIDRKHKKNIYC CHHHCCHHHHCCEEE	56.90	-
630	Ubiquitination	DKIDRKHKKNIYCLE HHCCHHHHCCEEEEC	51.02	-
634	Phosphorylation	RKHKKNIYCLENCSP HHHHCCEEEECCCCC	10.61	25293948
640	Phosphorylation	IYCLENCSPVSSKEP EEEECCCCCCCCCCC	39.66	22817900
643	Phosphorylation	LENCSPVSSKEPMKA ECCCCCCCCCCCCCC	38.79	28066266
644	Phosphorylation	ENCSPVSSKEPMKAD CCCCCCCCCCCCCCC	41.07	28066266
768	Phosphorylation	DVSLKDGSVGKTSKP CCCCCCCCCCCCCCC	37.52	24719451
773	Phosphorylation	DGSVGKTSKPSFKLQ CCCCCCCCCCCCCCC	46.16	24719451
852	Phosphorylation	DKHEEQKSQNSSLFK CHHHHHHHHCCHHHH	34.00	-
864	Phosphorylation	LFKKEIKSEELDNSS HHHHHHCHHHCCCCC	41.80	28066266
870	Phosphorylation	KSEELDNSSSDDEDK CHHHCCCCCCCHHHH	30.77	22817900
871	Phosphorylation	SEELDNSSSDDEDKL HHHCCCCCCCHHHHH	44.00	22817900
872	Phosphorylation	EELDNSSSDDEDKLQ HHCCCCCCCHHHHHH	49.23	21082442
938	Phosphorylation	EGQVPHDSSKPLVAG CCCCCCCCCCCCCCC	36.91	-
973	Phosphorylation	SGLSKQNSFQLQKGD CCCCCCCCEECCCCC	16.33	27149854
1002	Phosphorylation	RGQVIVISDSDEEED CCEEEEEECCCCCCC	21.84	22817900
1004	Phosphorylation	QVIVISDSDEEEDED EEEEEECCCCCCCCC	39.88	22817900
1016	Phosphorylation	DEDEDERSSSEENIK CCCCCHHCCHHHHHH	35.85	25293948
1017	Phosphorylation	EDEDERSSSEENIKQ CCCCHHCCHHHHHHH	48.25	25293948
1018	Phosphorylation	DEDERSSSEENIKQS CCCHHCCHHHHHHHH	50.61	25293948
1056	Phosphorylation	LVKEEERYPVEFEDS HCCHHHHCCCCCCCC	18.21	22802335
1073	Phosphorylation	QVFEFESSSEVFSVW CEEEEECCCHHEEHE	24.26	22802335
1074	Phosphorylation	VFEFESSSEVFSVWQ EEEEECCCHHEEHEE	47.24	22802335
1078	Phosphorylation	ESSSEVFSVWQDHKI ECCCHHEEHEECCCC	27.85	22802335
1136	Phosphorylation	KEHAGPHSSVSAEEF HHHCCCCCCCCHHHH	35.25	22871156
1137	Phosphorylation	EHAGPHSSVSAEEFC HHCCCCCCCCHHHHH	19.63	22871156
1146	Phosphorylation	SAEEFCKTGVKKPKR CHHHHHHHCCCCCCC	48.68	27149854
1227	Phosphorylation	PVRKVPASKATKKTH CCCCCCCCCCCCCCC	19.43	20139300
1230	Phosphorylation	KVPASKATKKTHSDT CCCCCCCCCCCCCCC	36.49	20139300
1233	Phosphorylation	ASKATKKTHSDTRRG CCCCCCCCCCCCCCC	28.33	27149854
1235	Phosphorylation	KATKKTHSDTRRGQS CCCCCCCCCCCCCCC	46.00	27149854
1237	Phosphorylation	TKKTHSDTRRGQSKS CCCCCCCCCCCCCCC	25.86	27149854
1243	Ubiquitination	DTRRGQSKSSCYISC CCCCCCCCCCEEEEE	38.20	-
1318	Phosphorylation	PKKAKLISPQTLSIK CCCCCCCCCCEEEEC	22.76	28066266
1332	Phosphorylation	KNNKKLLTSQDLQFQ CCCCCEECCHHHHHH	34.48	28066266
1333	Phosphorylation	NNKKLLTSQDLQFQR CCCCEECCHHHHHHH	22.97	28066266
1369	Phosphorylation	VSRIVQGSDVLEADS EEEEECCCCCEECCC	13.88	23984901
1376	Phosphorylation	SDVLEADSDEPDDHR CCCEECCCCCCCCCC	51.42	27087446
1385	Phosphorylation	EPDDHRVSEPLAISN CCCCCCCCCCCEECC	33.19	25293948
1391	Phosphorylation	VSEPLAISNEKQLAK CCCCCEECCHHHHHH	33.07	25293948
1431	Phosphorylation	QCESRVLSGGVPTDV HHHHHHHCCCCCCCE	30.55	19367708
1444	Phosphorylation	DVVMVSASEDPVDGG CEEEEECCCCCCCCC	34.72	19367708
1470	Phosphorylation	VKAAEPASSSDTDDD EEECCCCCCCCCCCC	40.88	19060867
1471	Phosphorylation	KAAEPASSSDTDDDD EECCCCCCCCCCCCC	34.05	19060867
1472	Phosphorylation	AAEPASSSDTDDDDN ECCCCCCCCCCCCCC	41.87	22817900
1474	Phosphorylation	EPASSSDTDDDDNLF CCCCCCCCCCCCCCC	43.19	22817900
1483	Phosphorylation	DDDNLFLTQHDPQDM CCCCCCCCCCCHHCC	19.27	25293948
1494	Phosphorylation	PQDMDLCSQLENKTI HHCCCHHHHHCCCEE	45.13	25293948
1515	Phosphorylation	DTVQREDSLSRPQLE CCCCCCCCCCCHHHH	24.40	29899451
1517	Phosphorylation	VQREDSLSRPQLESL CCCCCCCCCHHHHHC	45.96	20139300
1525	Phosphorylation	RPQLESLSITKCKYK CHHHHHCEEEECCHH	37.17	20139300
1527	Phosphorylation	QLESLSITKCKYKDC HHHHCEEEECCHHHH	27.32	20139300
1610	Phosphorylation	SALKNKSSGAQPNLK HHHHCCCCCCCCCCC	39.49	22802335
1656	Phosphorylation	SKQSCKLTFSENRPT CCCEEEEEECCCCCC	15.60	26643407
1658	Phosphorylation	QSCKLTFSENRPTSA CEEEEEECCCCCCCC	28.82	26643407
1663	Phosphorylation	TFSENRPTSAASPVN EECCCCCCCCCCCCE	27.97	26643407
1664	Phosphorylation	FSENRPTSAASPVNI ECCCCCCCCCCCCEE	25.23	26643407
1667	Phosphorylation	NRPTSAASPVNILLP CCCCCCCCCCEEECC	29.15	26643407
1892	Phosphorylation	PNPMDFCTKDLLTTT CCHHCCCCHHHCCCC	27.82	-
1900	Phosphorylation	KDLLTTTSERIVAYL HHHCCCCHHHHHHHH	23.84	22942356
1954	Phosphorylation	KTIVGLLYRLLTENQ HHHHHHHHHHHHHCH	12.31	28285833
1958	Phosphorylation	GLLYRLLTENQRKGH HHHHHHHHHCHHCCC	37.17	28285833
1966	Phosphorylation	ENQRKGHSDENFNAK HCHHCCCCCCCCCHH	56.11	19854140
2387	Phosphorylation	SLQRLNVTITRAKYS CHHHHCEEEEEHHHH	18.63	23140645
2389	Phosphorylation	QRLNVTITRAKYSLF HHHCEEEEEHHHHHH	18.40	23140645
2440	Acetylation	HDAMKILKLKPVLQR CCHHHHHCHHHHHHH	58.92	23864654
2448	Phosphorylation	LKPVLQRSLTHPPAT HHHHHHHHCCCCCCC	25.34	25266776
2450	Phosphorylation	PVLQRSLTHPPATAP HHHHHHCCCCCCCCC	33.32	26643407
2455	Phosphorylation	SLTHPPATAPEAPRP HCCCCCCCCCCCCCC	48.82	26643407
2588	Phosphorylation	AHPAAAASTSKRKYS CCCCHHCCCCCCCCC	28.61	18779572
2594	Phosphorylation	ASTSKRKYSDPDAGL CCCCCCCCCCCCCCC	23.49	25777480
2595	Phosphorylation	STSKRKYSDPDAGLS CCCCCCCCCCCCCCC	45.78	25159016
2602	Phosphorylation	SDPDAGLSHKREPRA CCCCCCCCCCCCCCC	26.50	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SETX_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SETX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SETX_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SETX_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.