T2EB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T2EB_MOUSE
• UniProt AC: Q9D902
• Protein Name: General transcription factor IIE subunit 2
• Gene Name: Gtf2e2
• Organism: Mus musculus (Mouse).
• Sequence Length: 292
• Subcellular Localization: Nucleus .
• Protein Description: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity)..
• Protein Sequence: MDPSLLRDRELFKKRALSTPVVEKRAVPSESPSSSSSKKKKAKVEHGGSSGSKQNSDHNNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVSRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITPGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPSLLRD -------CCHHHHHC	18.04	-
18	Phosphorylation	LFKKRALSTPVVEKR HHHHHCCCCCEECCC	29.67	26824392
19	Phosphorylation	FKKRALSTPVVEKRA HHHHCCCCCEECCCC	22.43	28066266
29	Phosphorylation	VEKRAVPSESPSSSS ECCCCCCCCCCCCCC	44.07	23984901
31	Phosphorylation	KRAVPSESPSSSSSK CCCCCCCCCCCCCCC	34.13	26824392
33	Phosphorylation	AVPSESPSSSSSKKK CCCCCCCCCCCCCHH	52.73	25266776
34	Phosphorylation	VPSESPSSSSSKKKK CCCCCCCCCCCCHHH	37.31	23984901
35	Phosphorylation	PSESPSSSSSKKKKA CCCCCCCCCCCHHHC	42.86	28066266
36	Phosphorylation	SESPSSSSSKKKKAK CCCCCCCCCCHHHCC	48.39	23984901
37	Phosphorylation	ESPSSSSSKKKKAKV CCCCCCCCCHHHCCC	50.90	27149854
62	Phosphorylation	NSDHNNGSFNLKALS CCCCCCCCEEEEEEC	17.06	-
72	Phosphorylation	LKALSGSSGYKFGVL EEEECCCCCCHHHHH	50.06	27149854
75	Acetylation	LSGSSGYKFGVLAKI ECCCCCCHHHHHHHH	38.88	23806337
115	Ubiquitination	QHLDIGLKQKQWLMT CCCCCCHHHHHHHHH	50.68	-
181	Ubiquitination	EGLPNSQKAVKALGD HCCCCCHHHHHHHCC	55.77	-
256	Phosphorylation	SGPKKVASIQRRKKP HCHHHHHHHHHCCCC	23.42	24719451
286	Phosphorylation	AGVLKDYSDITPGK- HHHHCCHHCCCCCC-	32.44	26745281
289	Phosphorylation	LKDYSDITPGK---- HCCHHCCCCCC----	30.86	22006019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T2EB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T2EB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T2EB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
T2EA_MOUSE	Gtf2e1	physical	20211142
TADBP_MOUSE	Tardbp	physical	20211142
T2EA_HUMAN	GTF2E1	physical	26496610
TAU_HUMAN	MAPT	physical	26496610
2AAA_HUMAN	PPP2R1A	physical	26496610
2A5E_HUMAN	PPP2R5E	physical	26496610
TICN1_HUMAN	SPOCK1	physical	26496610
SPT6H_HUMAN	SUPT6H	physical	26496610
ABI1_HUMAN	ABI1	physical	26496610
WASF2_HUMAN	WASF2	physical	26496610
CASC3_HUMAN	CASC3	physical	26496610
CYFP1_HUMAN	CYFIP1	physical	26496610
NHSL1_HUMAN	NHSL1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.