T2EA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T2EA_MOUSE
• UniProt AC: Q9D0D5
• Protein Name: General transcription factor IIE subunit 1
• Gene Name: Gtf2e1
• Organism: Mus musculus (Mouse).
• Sequence Length: 440
• Subcellular Localization: Nucleus.
• Protein Description: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase..
• Protein Sequence: MADPDVLTEVPAALKRLAKYVIRGFYGIEHVLALDILIRNPCVKEEDMLELLKFDRKQLRSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERNSTNRASFKCPVCCSTFTDLEANQLFDPMTGTFRCTFCHTEVEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDRAATAAGAAGLAGGHHREAWTNKGPSYEDLYTQNVVINMDDQDDVHRPSLEGKAAKERPIWLRESTVQGAYSSEEMKEGGIDVDTFQEREEARAGPDDNEEVMRALLIHEKKTSSVTAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAAAPPHHHRDEDEEDEEFEEVADDPIVMVAGCPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADPDVLTE ------CCCHHHHHH	36.72	-
19	Acetylation	AALKRLAKYVIRGFY HHHHHHHHHHHHHCC	44.64	22826441
44	Acetylation	LIRNPCVKEEDMLEL HHHCCCCCHHHHHHH	63.20	22826441
67	Acetylation	RSVLNNLKGDKFIKC HHHHHHCCCCCEEEE	68.16	23806337
67	Malonylation	RSVLNNLKGDKFIKC HHHHHHCCCCCEEEE	68.16	26320211
91	Phosphorylation	GKTTRHNYYFINYRT CCCEECCEEEEEHHH	8.14	-
188	Phosphorylation	NEQIEPIYALLRETE HHHHHHHHHHHHHCC	11.25	22817900
268	Phosphorylation	QDDVHRPSLEGKAAK CCCCCCCCCCCHHHH	38.72	25338131
291	Phosphorylation	STVQGAYSSEEMKEG CCCCCCCCHHHHHHC	30.64	26643407
292	Phosphorylation	TVQGAYSSEEMKEGG CCCCCCCHHHHHHCC	25.54	26643407
365	Phosphorylation	TSESDDDSPPRPAAA CCCCCCCCCCCCCCC	43.74	23384938

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T2EA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T2EA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T2EA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TADBP_MOUSE	Tardbp	physical	20211142
ZBTB9_MOUSE	Zbtb9	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.