EHMT1_MOUSE - dbPTM
EHMT1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EHMT1_MOUSE
UniProt AC Q5DW34
Protein Name Histone-lysine N-methyltransferase EHMT1
Gene Name Ehmt1
Organism Mus musculus (Mouse).
Sequence Length 1296
Subcellular Localization Nucleus . Chromosome . Associates with euchromatic regions.
Protein Description Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53..
Protein Sequence MAAADAEQAVLAKQETKQDCCMKTELLREDTPMAADEGSTEKQEGETPMAADGETNGSCEKSGDPSHLNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNILTSSLPGHAAKTLPGGASKCRTLSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKALDDSALHVNGESLEMDSEDEDSDELEDDEDHGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLASGPDVLGTDGLQEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEEASKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDERSQSTAPQAPECFDPAGPAGLVRPTSGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLSSQVWSALQMSKALRDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSSKCRHSSAALAQRQASAAQEPQENGLPDTSSAAAADPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAADAEQA
------CCHHHHHHH		23.74-
31PhosphorylationTELLREDTPMAADEG
HHHHHCCCCCCCCCC		15.3726643407
40PhosphorylationMAADEGSTEKQEGET
CCCCCCCCCCCCCCC		59.0428576409
74PhosphorylationHLNAPKHTQENTRAS
HCCCCCCCCCCCCCC		43.6425777480
78PhosphorylationPKHTQENTRASPQEG
CCCCCCCCCCCCCCC		27.1925159016
81PhosphorylationTQENTRASPQEGTNR
CCCCCCCCCCCCCHH		24.6727087446
86PhosphorylationRASPQEGTNRVSRVA
CCCCCCCCHHHHHHH		21.0625777480
165PhosphorylationGGASKCRTLSALPQT
CCHHHCCCCCCCCCC		34.2426643407
167PhosphorylationASKCRTLSALPQTPT
HHHCCCCCCCCCCCC		27.4426643407
172PhosphorylationTLSALPQTPTTAPTV
CCCCCCCCCCCCCCC		22.2126643407
174PhosphorylationSALPQTPTTAPTVPG
CCCCCCCCCCCCCCC		38.6926643407
175PhosphorylationALPQTPTTAPTVPGE
CCCCCCCCCCCCCCC		31.6626643407
178PhosphorylationQTPTTAPTVPGEGSA
CCCCCCCCCCCCCCC		36.5526643407
211PhosphorylationARKTMPKSILGLHAA
CCCCCCHHHHHHHHC		19.7129176673
219PhosphorylationILGLHAASKDHREVQ
HHHHHHCCCCHHHHH		39.1229514104
220AcetylationLGLHAASKDHREVQD
HHHHHCCCCHHHHHC		53.4822902405
257PhosphorylationTFPALHQSLPQNQCY
CCHHHHHHCCCCCCE		31.1328285833
294PhosphorylationKKRRMGTYSLVPKKK
HHHCCCCCCCCCCCC		8.3519854140
316PhosphorylationTVIEMFKSITHSTVG
HHHHHHHHCCCCCCC		22.8129895711
318PhosphorylationIEMFKSITHSTVGAK
HHHHHHCCCCCCCCC		19.5029895711
320PhosphorylationMFKSITHSTVGAKGE
HHHHCCCCCCCCCCC		19.0129895711
321PhosphorylationFKSITHSTVGAKGEK
HHHCCCCCCCCCCCC		18.4929895711
341PhosphorylationALHVNGESLEMDSED
CEEECCCCCCCCCCC		30.9122668510
346PhosphorylationGESLEMDSEDEDSDE
CCCCCCCCCCCCCCC		45.7122668510
351PhosphorylationMDSEDEDSDELEDDE
CCCCCCCCCCCCCCC		30.8222668510
379PhosphorylationDSRTSKESMSETDRA
CCCCCHHHCCHHHHH		31.2025619855
381PhosphorylationRTSKESMSETDRAAK
CCCHHHCCHHHHHHH		46.7725619855
383PhosphorylationSKESMSETDRAAKMD
CHHHCCHHHHHHHCC		24.3928066266
393PhosphorylationAAKMDGDSEEEQESP
HHHCCCCCHHHHCCC		53.0625338131
399PhosphorylationDSEEEQESPDTGEDE
CCHHHHCCCCCCCCC		27.9825338131
402PhosphorylationEEQESPDTGEDEDGG
HHHCCCCCCCCCCCC		45.9425338131
433PhosphorylationKRRGKTDSPWIKPAR
HHCCCCCCCCCHHHH		27.6325266776
461PhosphorylationLGSEACKSSPGSMEQ
HCHHHHHCCCCCHHH		41.4726643407
462PhosphorylationGSEACKSSPGSMEQA
CHHHHHCCCCCHHHH		20.8323649490
465PhosphorylationACKSSPGSMEQAALG
HHHCCCCCHHHHHHC		23.6423649490
474PhosphorylationEQAALGDSAGYMEVS
HHHHHCCCCCEEEEE		23.0726643407
481PhosphorylationSAGYMEVSLDSLDLR
CCCEEEEEHHHHHHH		17.10-
494PhosphorylationLRVRGILSSQTENEG
HHHHHHHCCCCCCCC		20.6222006019
579DimethylationLVLCEDHRGRMVKHQ
EEEECCCCCCEECCC		46.89-
670PhosphorylationAEGRADTTTGSIAGA
HCCCCCCCCCCCCCC		29.7022006019
765AcetylationDGIDPNFKMEHQSKR
CCCCCCCCCCCCCCC		50.446567285
825UbiquitinationDAVKYLIKAGAQVDP
HHHHHHHHCCCCCCC		37.8722790023
996PhosphorylationMSKALRDSAPDKPVA
HHHHHHHCCCCCCEE		34.9622942356
1009PhosphorylationVAVEKTVSRDIARGY
EEEEEECCHHHHCCC		29.4822942356
1046PhosphorylationVSQNCVTSPMNIDRN
ECCCCCCCCCCCCCC		11.1825338131
1213PhosphorylationVPVRVFMSHQDLRFP
EEEEEECCCCCCCCC		13.41-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EHMT1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EHMT1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EHMT1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DNM3A_MOUSEDnmt3aphysical
22086334
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EHMT1_MOUSE

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Related Literatures of Post-Translational Modification

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