LRRF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRF2_MOUSE
• UniProt AC: Q91WK0
• Protein Name: Leucine-rich repeat flightless-interacting protein 2
• Gene Name: Lrrfip2
• Organism: Mus musculus (Mouse).
• Sequence Length: 415
• Protein Description: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)..
• Protein Sequence: MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQREGVEDTLSLRSLGSHRLDEKSDKQYAENYTRPSSRNSASATTPLSGQSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PGSGRKRTPVKDRFS CCCCCCCCCCCCCCC	35.15	-
18	Phosphorylation	TPVKDRFSAEDEALS CCCCCCCCHHHHHHH	31.48	26824392
68 (in isoform 2)	Phosphorylation	-	26.85	29514104
79	Phosphorylation	SHRLDEKSDKQYAEN CCCCCHHHHHHHHHH	48.25	25777480
83	Phosphorylation	DEKSDKQYAENYTRP CHHHHHHHHHHCCCC	22.94	25777480
87	Phosphorylation	DKQYAENYTRPSSRN HHHHHHHCCCCCCCC	8.81	25777480
88	Phosphorylation	KQYAENYTRPSSRNS HHHHHHCCCCCCCCC	47.92	24899341
91	Phosphorylation	AENYTRPSSRNSASA HHHCCCCCCCCCCCC	38.34	25266776
92	Phosphorylation	ENYTRPSSRNSASAT HHCCCCCCCCCCCCC	37.86	27742792
95	Phosphorylation	TRPSSRNSASATTPL CCCCCCCCCCCCCCC	23.61	21183079
100	Phosphorylation	RNSASATTPLSGQSS CCCCCCCCCCCCCCC	23.19	-
103	Phosphorylation	ASATTPLSGQSSRRG CCCCCCCCCCCCCCC	35.67	-
106	Phosphorylation	TTPLSGQSSRRGSGD CCCCCCCCCCCCCCC	29.36	-
107	Phosphorylation	TPLSGQSSRRGSGDT CCCCCCCCCCCCCCH	20.36	-
111	Phosphorylation	GQSSRRGSGDTSSLI CCCCCCCCCCHHHCC	31.51	24925903
114	Phosphorylation	SRRGSGDTSSLIDPD CCCCCCCHHHCCCCC	24.60	24925903
115	Phosphorylation	RRGSGDTSSLIDPDT CCCCCCHHHCCCCCC	28.08	24925903
116	Phosphorylation	RGSGDTSSLIDPDTS CCCCCHHHCCCCCCC	31.28	24925903
122	Phosphorylation	SSLIDPDTSLSELRE HHCCCCCCCHHHHHH	36.63	25619855
123	Phosphorylation	SLIDPDTSLSELRES HCCCCCCCHHHHHHH	36.96	25619855
125	Phosphorylation	IDPDTSLSELRESLS CCCCCCHHHHHHHHH	34.06	25619855
299	Phosphorylation	CSRNDGMSGDLAGLQ HHCCCCCCHHCCCCC	34.38	22802335
375	Acetylation	ELKAERRKLQRELRT HHHHHHHHHHHHHHH	56.01	8440431

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRRF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-114 AND SER-116, ANDMASS SPECTROMETRY.
PubMed: 17242355