SEN15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEN15_MOUSE
• UniProt AC: Q8R3W5
• Protein Name: tRNA-splicing endonuclease subunit Sen15
• Gene Name: Tsen15
• Organism: Mus musculus (Mouse).
• Sequence Length: 168
• Subcellular Localization: Nucleus . Nucleus, nucleolus . May be transiently localized in the nucleolus.
• Protein Description: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity)..
• Protein Sequence: MEERSDSEPTPGCSGPGPAPVRDGGGAHTWAPEDAWMGTHPKYLEMMELDIGDATQVYIAFLVYLDLMESKSWHEVNCVGIPELQLICLLGTEIEGEGLQTVVPTPISASLSHNRIREILKASRKLQGDPELPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEERSDSEPTPG ---CCCCCCCCCCCC	49.09	25619855
7	Phosphorylation	-MEERSDSEPTPGCS -CCCCCCCCCCCCCC	46.88	28066266
10	Phosphorylation	ERSDSEPTPGCSGPG CCCCCCCCCCCCCCC	28.41	28066266
165	Phosphorylation	LPDPQNISLRR---- CCCCCCCCCCC----	24.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEN15_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEN15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEN15_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SEN15_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.