dbPTM

GTR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GTR1_MOUSE
UniProt AC	P17809
Protein Name	Solute carrier family 2, facilitated glucose transporter member 1
Gene Name	Slc2a1
Organism	Mus musculus (Mouse).
Sequence Length	492
Subcellular Localization	Cell membrane Multi-pass membrane protein . Melanosome. Localizes primarily at the cell surface..
Protein Description	Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses..
Protein Sequence	MDPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGEPIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVAAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLERLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPSSKKV -------CCHHHHHC	18.04	-
45	N-linked_Glycosylation	KVIEEFYNQTWNHRY HHHHHHHHHCCCCCC	37.82	19656770
49	N-linked_Glycosylation	EFYNQTWNHRYGEPI HHHHHCCCCCCCCCC	17.10	19656770
113	Phosphorylation	AAVLMGFSKLGKSFE HHHHHCHHHHCHHHH	22.65	28059163
226	Phosphorylation	NEENRAKSVLKKLRG CHHHHHHHHHHHHHC	31.53	24453211
234	Phosphorylation	VLKKLRGTADVTRDL HHHHHHCCCHHHHHH	17.16	19144319
241	Ubiquitination	TADVTRDLQEMKEEG CCHHHHHHHHHHHHH	4.13	27667366
245	Ubiquitination	TRDLQEMKEEGRQMM HHHHHHHHHHHHHHH	52.43	22790023
465	Phosphorylation	RTFDEIASGFRQGGA CCHHHHHHHHHCCCC	44.09	22006019
473	Phosphorylation	GFRQGGASQSDKTPE HHHCCCCCCCCCCHH	33.23	26239621
475	Phosphorylation	RQGGASQSDKTPEEL HCCCCCCCCCCHHHH	38.28	26239621
477	Ubiquitination	GGASQSDKTPEELFH CCCCCCCCCHHHHCC	71.83	22790023
478	Phosphorylation	GASQSDKTPEELFHP CCCCCCCCHHHHCCC	40.71	22942356
490	Phosphorylation	FHPLGADSQV----- CCCCCCCCCC-----	32.10	28978645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GTR1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
226	S	Phosphorylation		-
Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GTR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GTR1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GTR1_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45 AND ASN-49, AND MASSSPECTROMETRY.	19349973 [Abstract]
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation."; Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.; Mol. Cell. Proteomics 8:2555-2569(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45 AND ASN-49, AND MASSSPECTROMETRY.	19656770 [Abstract]
Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234, AND MASSSPECTROMETRY.	19144319 [Abstract]