dbPTM

CLIC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLIC1_MOUSE
UniProt AC	Q9Z1Q5
Protein Name	Chloride intracellular channel protein 1
Gene Name	Clic1
Organism	Mus musculus (Mouse).
Sequence Length	241
Subcellular Localization	Nucleus. Nucleus membrane Single-pass membrane protein. Cytoplasm. Cell membrane Single-pass membrane protein. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cy
Protein Description	Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity)..
Protein Sequence	MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAMLCPPRYPKLAALNPESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVARALK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEEQPQVE ------CCCCCCCEE	29.09	-
13	Acetylation	PQVELFVKAGSDGAK CCEEEEEEECCCCCE	39.43	-
24	Glutathionylation	DGAKIGNCPFSQRLF CCCEECCCCHHHHHH	2.80	24333276
24	S-nitrosylation	DGAKIGNCPFSQRLF CCCEECCCCHHHHHH	2.80	21278135
24	S-nitrosocysteine	DGAKIGNCPFSQRLF CCCEECCCCHHHHHH	2.80	-
49	Acetylation	NVTTVDTKRRTETVQ EEEECCCCCCCHHHH	35.10	130729
93	Phosphorylation	AMLCPPRYPKLAALN HHCCCCCCCCHHHCC	15.53	22817900
103	Phosphorylation	LAALNPESNTSGLDI HHHCCCCCCCCCCHH	46.82	22817900
105	Phosphorylation	ALNPESNTSGLDIFA HCCCCCCCCCCHHHH	33.19	23984901
106	Phosphorylation	LNPESNTSGLDIFAK CCCCCCCCCCHHHHH	41.42	24719451
119	Acetylation	AKFSAYIKNSNPALN HHHHHHHHCCCHHHC	41.46	22826441
119	Malonylation	AKFSAYIKNSNPALN HHHHHHHHCCCHHHC	41.46	26320211
119	Ubiquitination	AKFSAYIKNSNPALN HHHHHHHHCCCHHHC	41.46	-
121	Phosphorylation	FSAYIKNSNPALNDN HHHHHHCCCHHHCCC	38.91	27180971
131	Ubiquitination	ALNDNLEKGLLKALK HHCCCHHHHHHHHHH	59.01	-
131	Acetylation	ALNDNLEKGLLKALK HHCCCHHHHHHHHHH	59.01	23806337
135	Acetylation	NLEKGLLKALKVLDN CHHHHHHHHHHHHHH	57.63	22733758
135	Malonylation	NLEKGLLKALKVLDN CHHHHHHHHHHHHHH	57.63	26320211
138	Ubiquitination	KGLLKALKVLDNYLT HHHHHHHHHHHHHHC	45.68	-
143	Phosphorylation	ALKVLDNYLTSPLPE HHHHHHHHHCCCCCH	15.83	25619855
145	Phosphorylation	KVLDNYLTSPLPEEV HHHHHHHCCCCCHHC	20.24	25619855
146	Phosphorylation	VLDNYLTSPLPEEVD HHHHHHCCCCCHHCC	23.11	25619855
155	Phosphorylation	LPEEVDETSAEDEGI CCHHCCCCCCCCCCC	28.86	25619855
156	Phosphorylation	PEEVDETSAEDEGIS CHHCCCCCCCCCCCC	27.84	25619855
163	Phosphorylation	SAEDEGISQRKFLDG CCCCCCCCCCCCCCC	34.49	25619855
166	Acetylation	DEGISQRKFLDGNEL CCCCCCCCCCCCCCC	42.51	22826441
178	Glutathionylation	NELTLADCNLLPKLH CCCCHHHCCCCCCCE	3.00	24333276
191	S-nitrosylation	LHIVQVVCKKYRGFT CEEEEHHHHHHCCCC	3.10	21278135
191	S-nitrosocysteine	LHIVQVVCKKYRGFT CEEEEHHHHHHCCCC	3.10	-
211	Phosphorylation	RGVHRYLSNAYAREE HHHHHHHHHHHHHHH	15.52	24899341
221	Phosphorylation	YAREEFASTCPDDEE HHHHHHHHHCCCHHH	35.54	30635358
222	Phosphorylation	AREEFASTCPDDEEI HHHHHHHHCCCHHHH	25.32	30635358
223	Glutathionylation	REEFASTCPDDEEIE HHHHHHHCCCHHHHH	3.01	24333276
223	S-nitrosylation	REEFASTCPDDEEIE HHHHHHHCCCHHHHH	3.01	21278135
223	S-nitrosocysteine	REEFASTCPDDEEIE HHHHHHHCCCHHHHH	3.01	-
233	Phosphorylation	DEEIELAYEQVARAL HHHHHHHHHHHHHHH	21.37	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
146	S	Phosphorylation	Kinase	MAPK14	P47811	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLIC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLIC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CLIC1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLIC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-233, AND MASSSPECTROMETRY.	17947660 [Abstract]