| UniProt ID | GCP3_MOUSE | |
|---|---|---|
| UniProt AC | P58854 | |
| Protein Name | Gamma-tubulin complex component 3 | |
| Gene Name | Tubgcp3 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 905 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. | |
| Protein Description | Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.. | |
| Protein Sequence | MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYYARPQTLPLNYQDRSTQAQSSGSLGSSGISSIGMCGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSSQTPTSKGFPNALSRNLTRSRREGDPGGTLEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAKANLNKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNRVQQAQDLDHIIAAHEAFLNTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDVMYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVVQQFLVLLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSHT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MATPDQKSP ------CCCCCCCCH | 28.04 | - | |
| 8 | Phosphorylation | MATPDQKSPNVLLQN CCCCCCCCHHHHHHH | 18.97 | - | |
| 113 | Phosphorylation | KQASKVTSYASLFAQ HHHHHHHHHHHHHHH | 22.99 | - | |
| 211 | Phosphorylation | TLTGNQPSSQTPTSK EECCCCCCCCCCCCC | 25.89 | 26745281 | |
| 212 | Phosphorylation | LTGNQPSSQTPTSKG ECCCCCCCCCCCCCC | 44.77 | 26745281 | |
| 214 | Phosphorylation | GNQPSSQTPTSKGFP CCCCCCCCCCCCCCC | 30.40 | 29514104 | |
| 216 | Phosphorylation | QPSSQTPTSKGFPNA CCCCCCCCCCCCCCH | 46.59 | 26745281 | |
| 217 | Phosphorylation | PSSQTPTSKGFPNAL CCCCCCCCCCCCCHH | 31.80 | 26745281 | |
| 254 | Phosphorylation | ALVRDILYVFQGIDG HHHHHHHHHHCCCCC | 10.27 | - | |
| 267 | Phosphorylation | DGKNIKMSSTENCYK CCCCCCCCCCCCEEE | 29.16 | 30635358 | |
| 268 | Phosphorylation | GKNIKMSSTENCYKV CCCCCCCCCCCEEEH | 35.92 | 17203969 | |
| 269 | Phosphorylation | KNIKMSSTENCYKVE CCCCCCCCCCEEEHH | 24.74 | 17203969 | |
| 273 | Phosphorylation | MSSTENCYKVEAKAN CCCCCCEEEHHHHHH | 29.65 | 30635358 | |
| 396 | Phosphorylation | RKGGELASAVHAYTK CCCCHHHHHHHHHHC | 43.37 | 22817900 | |
| 467 | Phosphorylation | DKYTLRKSMIPSFIT CHHHCCHHCCCCEEC | 18.60 | 24759943 | |
| 510 | Phosphorylation | KMIAVTKSAESPRDA EEEEEECCCCCHHHH | 28.09 | 26239621 | |
| 513 | Phosphorylation | AVTKSAESPRDAADL EEECCCCCHHHHHHH | 25.59 | 26239621 | |
| 522 | Phosphorylation | RDAADLFTDLENAFQ HHHHHHHHHHHHHHC | 47.15 | 26160508 | |
| 542 | Phosphorylation | AYFETSKYLLDVLNK HHHHHHHHHHHHHHH | 16.56 | 29109428 | |
| 791 | Phosphorylation | QNAQDVMYRAALEEL CCHHHHHHHHHHHHH | 9.28 | - | |
| 894 | Phosphorylation | REPRLRVSLGSRGRR CCCEEEEECCCCCCC | 22.15 | 25266776 | |
| 897 | Phosphorylation | RLRVSLGSRGRRSSH EEEEECCCCCCCCCC | 36.53 | 25367039 | |
| 902 | Phosphorylation | LGSRGRRSSHT---- CCCCCCCCCCC---- | 25.72 | - | |
| 903 | Phosphorylation | GSRGRRSSHT----- CCCCCCCCCC----- | 29.36 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCP3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCP3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCP3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GCP4_HUMAN | TUBGCP4 | physical | 20360068 | |
| GCP3_HUMAN | TUBGCP3 | physical | 20360068 | |
| GCP2_HUMAN | TUBGCP2 | physical | 20360068 | |
| TBG1_HUMAN | TUBG1 | physical | 20360068 | |
| TMOD3_HUMAN | TMOD3 | physical | 20360068 | |
| MISP_HUMAN | MISP | physical | 20360068 | |
| MZT1_HUMAN | MZT1 | physical | 20360068 | |
| GCP5_HUMAN | TUBGCP5 | physical | 20360068 | |
| NEXN_HUMAN | NEXN | physical | 20360068 | |
| GCP6_HUMAN | TUBGCP6 | physical | 20360068 | |
| NEDD1_HUMAN | NEDD1 | physical | 20360068 | |
| MZT2B_HUMAN | MZT2B | physical | 20360068 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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