PALM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PALM3_MOUSE
• UniProt AC: A2TJV2
• Protein Name: Paralemmin-3
• Gene Name: Palm3
• Organism: Mus musculus (Mouse).
• Sequence Length: 734
• Subcellular Localization: Cytoplasm. Cell membrane; Lipid-anchor.
• Protein Description: ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling..
• Protein Sequence: MALQTPVLSPATPTVMAESALYRQRLEVIAEKRRLQEEIGAARRELEEEKLRVERLKRKSLRERWLMDGAAEGPERPEEPASKDPQSPEGQAQARIRNLEDSLFSLQSQLQLLQSASTGAQHRPAGRPAWRREGPRPLSQSAMEAAPTAPTDVDKRTSLPDAPVGMSPESPSDPREESIAVLPASRPSTEAIGTSSEANGPCPGHSPLPEQLSLGVSSVTKAKGDGAVEVVWAGLRATENSATGPTDVELEAKVEEVVLEAIGARQGTSSPELPTWVKEGRGVVEVVWEGLGGRDLDVTGESGRDAEATHTSSRRLQEQFEAETCRKEEGASRDSLEGVGQGGPGVEEGSFIWVERVALSEDWEEILMEGLEAPQGAGSAGEPEALIGAQPRGGEASWEVEKREVEKVEGIEEKGRAEKLGAEREDGVAVLPDETQGREENEAEKVERKDSEGPFPAEIATDEEKWEVKTTEGEESLEVEKGGEAEPVTTEKPLVTEKKPEGSLETERKGSEMPLDQEKDGEGSLDRESKTTEILLDGEIGDKSSLDETKGSKKLLDEKTGGEGSLDEEAEGSKKLLDREADGIEPFSEVDKTSGAKDDVSPEEQGKANEGAEFQAEDASPPGATVCVQDEPRSEEQGQQEPEKQEGLVEGAASKPEPCTEREGPPGDATLLLAETPAPEQPVESQPLLHQEASSTNPGDHPAPTYAPAQQLELAEAKEASGPKQKTCQCCVVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ALQTPVLSPATPTVM CCCCCCCCCCCCCCC	16.84	22006019
32	Acetylation	RLEVIAEKRRLQEEI HHHHHHHHHHHHHHH	33.52	19844815
50	Acetylation	RRELEEEKLRVERLK HHHHHHHHHHHHHHH	44.89	30987077
87	Phosphorylation	PASKDPQSPEGQAQA CCCCCCCCHHHHHHH	30.24	25521595
139	Phosphorylation	REGPRPLSQSAMEAA CCCCCCCCHHHHHHC	25.44	27180971
141	Phosphorylation	GPRPLSQSAMEAAPT CCCCCCHHHHHHCCC	26.63	26239621
157	Phosphorylation	PTDVDKRTSLPDAPV CCCCCCCCCCCCCCC	40.11	26643407
158	Phosphorylation	TDVDKRTSLPDAPVG CCCCCCCCCCCCCCC	41.77	24899341
167	Phosphorylation	PDAPVGMSPESPSDP CCCCCCCCCCCCCCC	21.42	22817900
170	Phosphorylation	PVGMSPESPSDPREE CCCCCCCCCCCCCHH	32.84	24899341
172	Phosphorylation	GMSPESPSDPREESI CCCCCCCCCCCHHCE	70.31	22817900
268	Phosphorylation	AIGARQGTSSPELPT HHCCCCCCCCCCCCC	20.07	26239621
269	Phosphorylation	IGARQGTSSPELPTW HCCCCCCCCCCCCCC	51.20	26239621
270	Phosphorylation	GARQGTSSPELPTWV CCCCCCCCCCCCCCH	23.41	25521595
275	Phosphorylation	TSSPELPTWVKEGRG CCCCCCCCCHHCCCC	56.36	26643407
311	Phosphorylation	RDAEATHTSSRRLQE CCCHHCCHHHHHHHH	24.84	-
332	Phosphorylation	CRKEEGASRDSLEGV HHHHCCCCHHCCCCC	47.69	26643407
335	Phosphorylation	EEGASRDSLEGVGQG HCCCCHHCCCCCCCC	27.49	26643407
350	Phosphorylation	GPGVEEGSFIWVERV CCCCCCCCEEEEEEE	19.48	22006019
360	Phosphorylation	WVERVALSEDWEEIL EEEEEECCCCHHHHH	24.62	26643407
379	Phosphorylation	EAPQGAGSAGEPEAL CCCCCCCCCCCCCEE	32.35	26643407
397	Phosphorylation	QPRGGEASWEVEKRE CCCCCCCCEEEEHHH	21.33	25338131
419	Acetylation	EEKGRAEKLGAERED HHHCHHHHHCCCCCC	51.76	2387909
451	Phosphorylation	EKVERKDSEGPFPAE HHHHCCCCCCCCCCC	47.70	26239621
461	Phosphorylation	PFPAEIATDEEKWEV CCCCCCCCCHHHEEE	49.99	26643407
476	Phosphorylation	KTTEGEESLEVEKGG EECCCCCCEEEEECC	26.06	26643407
506	Phosphorylation	KPEGSLETERKGSEM CCCCCCCCCCCCCCC	46.51	-
524	Phosphorylation	QEKDGEGSLDRESKT CCCCCCCCCCCCCCC	23.85	24899341
544	Phosphorylation	DGEIGDKSSLDETKG CCCCCCCHHHCCCCC	40.65	26643407
545	Phosphorylation	GEIGDKSSLDETKGS CCCCCCHHHCCCCCH	45.65	26643407
549	Phosphorylation	DKSSLDETKGSKKLL CCHHHCCCCCHHHHH	40.13	26643407
565	Phosphorylation	EKTGGEGSLDEEAEG CCCCCCCCCCHHHHH	28.48	26643407
601	Phosphorylation	SGAKDDVSPEEQGKA CCCCCCCCHHHHCCC	33.32	25521595
620	Phosphorylation	EFQAEDASPPGATVC CCCCCCCCCCCCEEE	43.90	29899451
721	Phosphorylation	LAEAKEASGPKQKTC HHHHHHHHCCCCCCC	57.64	-
728	S-palmitoylation	SGPKQKTCQCCVVM- HCCCCCCCCEEEEC-	3.62	-
730	S-palmitoylation	PKQKTCQCCVVM--- CCCCCCCEEEEC---	1.75	-
731	Methylation	KQKTCQCCVVM---- CCCCCCEEEEC----	0.77	-
731	Farnesylation	KQKTCQCCVVM---- CCCCCCEEEEC----	0.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PALM3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
728	C	Palmitoylation	Palmitoylated on Cys-728 and Cys-730 and prenylated on Cys-731; which is required for membrane association.	-
730	C	Palmitoylation	Palmitoylated on Cys-728 and Cys-730 and prenylated on Cys-731; which is required for membrane association.	-
731	C	Palmitoylation	Palmitoylated on Cys-728 and Cys-730 and prenylated on Cys-731; which is required for membrane association.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PALM3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PALM3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.