TBC17_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC17_MOUSE
• UniProt AC: Q8BYH7
• Protein Name: TBC1 domain family member 17
• Gene Name: Tbc1d17
• Organism: Mus musculus (Mouse).
• Sequence Length: 645
• Subcellular Localization: Cytoplasmic vesicle, autophagosome.
• Protein Description: Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known (By similarity)..
• Protein Sequence: MEGSSYRVVFEKGGVYLHTSARKHQDPDSLIAGVIRVVEKDSDVFLHWAPVEEAGDPTQILFKKDPSRGEPSTSEEEPTFDPGYEPDWAVISTVRPQPHLAEPRKGAEPSSSRSSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPQDPSALSDSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPHPEGASSPNLPPLPDDEPEPGFEVISCVELGQRPTVERAPPVTEEEWNRYVGPEGRLQNVPELKNRIFSGGLSPGLRREAWKFLLGYLSWESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLSLLHDILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFCGFMELVHGNFEESQETMKRQLGQLLLLLRVLDQPLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALYRQLTACPELPHNVQEILGLAQPEEPSSPSPPVSPMPLSPTRAPLPPPLPEEVIPQPDSSLEILPEDEDGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEGSSYRVVFE ----CCCCCEEEEEE	15.76	24759943
5	Phosphorylation	---MEGSSYRVVFEK ---CCCCCEEEEEEE	28.02	29899451
6	Phosphorylation	--MEGSSYRVVFEKG --CCCCCEEEEEEEC	14.77	29899451
19	Phosphorylation	KGGVYLHTSARKHQD ECCEEEECCCCCCCC	22.83	30635358
20	Phosphorylation	GGVYLHTSARKHQDP CCEEEECCCCCCCCC	18.48	30635358
23	Ubiquitination	YLHTSARKHQDPDSL EEECCCCCCCCCCCC	45.38	-
175	Phosphorylation	SRYLLLASSPQDSRL HHHHHHHCCCCCCEE	42.39	29472430
176	Phosphorylation	RYLLLASSPQDSRLY HHHHHHCCCCCCEEE	22.45	29472430
180	Phosphorylation	LASSPQDSRLYLVFP HHCCCCCCEEEEEEC	20.95	22817900
219	Phosphorylation	SRFLQDPYSTTFSSF HHHHCCCCCCCCHHH	27.26	25367039
220	Phosphorylation	RFLQDPYSTTFSSFS HHHCCCCCCCCHHHH	26.76	25367039
221	Phosphorylation	FLQDPYSTTFSSFSR HHCCCCCCCCHHHHH	26.47	25367039
222	Phosphorylation	LQDPYSTTFSSFSRV HCCCCCCCCHHHHHH	18.64	25367039
224	Phosphorylation	DPYSTTFSSFSRVTN CCCCCCCHHHHHHHH	28.51	25367039
225	Phosphorylation	PYSTTFSSFSRVTNF CCCCCCHHHHHHHHH	24.05	25367039
227	Phosphorylation	STTFSSFSRVTNFFR CCCCHHHHHHHHHHC	27.99	25367039
303	Ubiquitination	LQNVPELKNRIFSGG CCCCHHHHHHHHCCC	42.38	-
366	Phosphorylation	AEQERRNSLLHGYRS HHHHHHHHHHHHHHH	30.42	27180971
579	Phosphorylation	EALYRQLTACPELPH HHHHHHHHCCCCCCC	20.20	25293948
601	Phosphorylation	LAQPEEPSSPSPPVS CCCCCCCCCCCCCCC	59.15	26643407
602	Phosphorylation	AQPEEPSSPSPPVSP CCCCCCCCCCCCCCC	39.86	26643407
604	Phosphorylation	PEEPSSPSPPVSPMP CCCCCCCCCCCCCCC	43.73	26824392
608	Phosphorylation	SSPSPPVSPMPLSPT CCCCCCCCCCCCCCC	22.66	26643407
613	Phosphorylation	PVSPMPLSPTRAPLP CCCCCCCCCCCCCCC	20.53	26643407
615	Phosphorylation	SPMPLSPTRAPLPPP CCCCCCCCCCCCCCC	35.77	25293948
633	Phosphorylation	EVIPQPDSSLEILPE HHCCCCCCCCEECCC	43.43	23737553
634	Phosphorylation	VIPQPDSSLEILPED HCCCCCCCCEECCCC	37.08	23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC17_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC17_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC17_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TBC17_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.