dbPTM

LIMC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LIMC1_MOUSE
UniProt AC	Q3UH68
Protein Name	LIM and calponin homology domains-containing protein 1
Gene Name	Limch1
Organism	Mus musculus (Mouse).
Sequence Length	1057
Subcellular Localization
Protein Description
Protein Sequence	MACPALGLEVLQPLQPEPPPEPAFAEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNTILFLRGCKELGLKESQLFDPSDLQDTSNRVTVKNLDYSRKLKNVLVTIYWLGKAANSCASYGGTTLNLKEFEGLLAQMRKETDDIDSPKRSIRDSGYIDCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDGRGSDSESDLPHRKLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEFRKSWSTATSPLGGERPFRYGPRTPVSDDAESTSMFDMRCEEEAAVLPHSRARQEQLQLINNQLREEDDKWQDDLARWKSRRRSASQDLIKKEEERKKMEKLMSGEDGTSERRKSIKTYREIVQEKERRERELHEAYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNVSSFPNDPSPMKYLRQQSLPPPKFTATVETTIARTSVPESIASAGTGSPSKIITPNTVPMLTPRPYSQPKNSQEVLKTFKVDGKVSMNGEMAPGDEEGKEKEGPAAAAPGPSLTKSQMFEGVATVHDSPVQVKQGSNSIEINIKKPNSAPQELTAASEETESNGQEDEDGEERPGTGDLEPDSAEPQHFTTTVTRCSPTVALVEFSSNPQLKNEVPEQGQKKPEDEMSGKVELVLSQKVAKPKSPEPEATLTFPFLDKMPETNQLHLPNPSSQADSPSSEKSPGSTPFKFWAWDPEEERRRQEKWQQEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTISSSSADQLSTSLSVTEGSGTRNKMDLENCPDKENERRQKTPFQENDGDSLLKTREGGLPEEQSLTPSPSANPEISVSKGIHQDPQLEAEAGAPHCGTNPQPAQDPPRNQQIPNPPTSTSEDVKPKTLALEKTINHQMESPGERRKSISGKKLCSSCGLTLGKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCTDCYMRSRSAGQPTTL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13 (in isoform 2)	Phosphorylation	-	28.89	26824392
35	Phosphorylation	QKWIEQVTGRSFGDK HHHHHHHHCCCCCCH	26.94	22324799
38	Phosphorylation	IEQVTGRSFGDKDFR HHHHHCCCCCCHHHC	34.62	22324799
129	Phosphorylation	KLKNVLVTIYWLGKA HHHHHEEEHHHCHHH	12.28	22006019
139	Phosphorylation	WLGKAANSCASYGGT HCHHHHHHHHHCCCC	13.31	29899451
142	Phosphorylation	KAANSCASYGGTTLN HHHHHHHHCCCCCCC	28.74	29899451
143	Phosphorylation	AANSCASYGGTTLNL HHHHHHHCCCCCCCH	10.89	29899451
169	Phosphorylation	KETDDIDSPKRSIRD HHCCCCCCCCHHHHH	32.43	25521595
173	Phosphorylation	DIDSPKRSIRDSGYI CCCCCCHHHHHCCCE	28.27	21082442
177	Phosphorylation	PKRSIRDSGYIDCWD CCHHHHHCCCEECCC	24.52	19060867
179	Phosphorylation	RSIRDSGYIDCWDSE HHHHHCCCEECCCCC	9.50	21183079
190	Phosphorylation	WDSERSDSLSPPRHG CCCCCCCCCCCCCCC	31.80	23737553
192	Phosphorylation	SERSDSLSPPRHGRD CCCCCCCCCCCCCCC	36.49	23737553
201	Phosphorylation	PRHGRDDSFDSLDSF CCCCCCCCCCCCCCC	34.93	25521595
204	Phosphorylation	GRDDSFDSLDSFGSR CCCCCCCCCCCCCCC	31.87	27742792
207	Phosphorylation	DSFDSLDSFGSRSRQ CCCCCCCCCCCCCCC	36.48	27742792
210	Phosphorylation	DSLDSFGSRSRQTPS CCCCCCCCCCCCCCC	25.68	27742792
212	Phosphorylation	LDSFGSRSRQTPSPD CCCCCCCCCCCCCCC	30.36	25521595
215	Phosphorylation	FGSRSRQTPSPDVVL CCCCCCCCCCCCEEE	25.32	24925903
217	Phosphorylation	SRSRQTPSPDVVLRG CCCCCCCCCCEEECC	36.80	25521595
225	Phosphorylation	PDVVLRGSSDGRGSD CCEEECCCCCCCCCC	20.87	27742792
226	Phosphorylation	DVVLRGSSDGRGSDS CEEECCCCCCCCCCC	47.08	21930439
231	Phosphorylation	GSSDGRGSDSESDLP CCCCCCCCCCCCCCC	36.28	25521595
233	Phosphorylation	SDGRGSDSESDLPHR CCCCCCCCCCCCCCC	40.47	25521595
235	Phosphorylation	GRGSDSESDLPHRKL CCCCCCCCCCCCCCC	48.69	22324799
246	Acetylation	HRKLPDVKKDDMSAR CCCCCCCCHHCCHHC	58.84	6569815
262	Phosphorylation	TSHGEPKSAVPFNQY CCCCCCCCCCCHHHC	45.26	21454597
269	Phosphorylation	SAVPFNQYLPNKSNQ CCCCHHHCCCCCCCC	25.82	21454597
274	Phosphorylation	NQYLPNKSNQTAYVP HHCCCCCCCCCEECC	40.59	21454597
297	Phosphorylation	EREEFRKSWSTATSP HHHHHHHHHHCCCCC	23.23	27180971
299	Phosphorylation	EEFRKSWSTATSPLG HHHHHHHHCCCCCCC	18.43	23737553
300	Phosphorylation	EFRKSWSTATSPLGG HHHHHHHCCCCCCCC	27.91	27742792
302	Phosphorylation	RKSWSTATSPLGGER HHHHHCCCCCCCCCC	30.85	23737553
303	Phosphorylation	KSWSTATSPLGGERP HHHHCCCCCCCCCCC	18.70	27180971
313	Phosphorylation	GGERPFRYGPRTPVS CCCCCCCCCCCCCCC	31.68	19060867
317	Phosphorylation	PFRYGPRTPVSDDAE CCCCCCCCCCCCCCC	31.04	27742792
320	Phosphorylation	YGPRTPVSDDAESTS CCCCCCCCCCCCCCC	30.86	21183079
327	Phosphorylation	SDDAESTSMFDMRCE CCCCCCCCCCCCCCH	27.08	21183079
377	Phosphorylation	RWKSRRRSASQDLIK HHHHHHHHHHHHHHH	30.38	25521595
379	Phosphorylation	KSRRRSASQDLIKKE HHHHHHHHHHHHHHH	26.02	27180971
397	Phosphorylation	KKMEKLMSGEDGTSE HHHHHHHCCCCCCHH	49.84	23737553
402	Phosphorylation	LMSGEDGTSERRKSI HHCCCCCCHHHHHHH	39.47	-
469	Phosphorylation	MPKILERSHSTEPNV CCHHHHCCCCCCCCC	16.65	23737553
471	Phosphorylation	KILERSHSTEPNVSS HHHHCCCCCCCCCHH	35.39	23737553
472	Phosphorylation	ILERSHSTEPNVSSF HHHCCCCCCCCCHHC	50.46	23737553
477	Phosphorylation	HSTEPNVSSFPNDPS CCCCCCCHHCCCCCC	32.66	24759943
493	Phosphorylation	MKYLRQQSLPPPKFT HHHHHHCCCCCCCCE	34.21	27180971
506	O-linked_Glycosylation	FTATVETTIARTSVP CEEEEEEEEECCCCC	10.11	22517741
518	Phosphorylation	SVPESIASAGTGSPS CCCHHHHCCCCCCCC	26.09	27742792
521	Phosphorylation	ESIASAGTGSPSKII HHHHCCCCCCCCCCC	33.91	23737553
523	Phosphorylation	IASAGTGSPSKIITP HHCCCCCCCCCCCCC	26.32	25521595
525	Phosphorylation	SAGTGSPSKIITPNT CCCCCCCCCCCCCCC	37.88	30372032
529	Phosphorylation	GSPSKIITPNTVPML CCCCCCCCCCCCCCC	17.60	-
532	O-linked_Glycosylation	SKIITPNTVPMLTPR CCCCCCCCCCCCCCC	27.47	55412447
537	Phosphorylation	PNTVPMLTPRPYSQP CCCCCCCCCCCCCCC	15.82	-
547	Phosphorylation	PYSQPKNSQEVLKTF CCCCCCCCHHHHHHE	33.57	21183079
603	Phosphorylation	GVATVHDSPVQVKQG CEEEECCCCCEEECC	16.46	19060867
613	Phosphorylation	QVKQGSNSIEINIKK EEECCCCEEEEEECC	24.24	28464351
672	Phosphorylation	TTTVTRCSPTVALVE EEEEEEECCEEEEEE	21.95	25521595
674	Phosphorylation	TVTRCSPTVALVEFS EEEEECCEEEEEEEC	11.34	24925903
682	Phosphorylation	VALVEFSSNPQLKNE EEEEEECCCHHHCCC	58.83	-
719	Phosphorylation	QKVAKPKSPEPEATL ECCCCCCCCCCCCEE	42.92	24925903
725	Phosphorylation	KSPEPEATLTFPFLD CCCCCCCEEECCCHH	25.35	24068923
727	Phosphorylation	PEPEATLTFPFLDKM CCCCCEEECCCHHCC	25.55	27742792
746	Phosphorylation	QLHLPNPSSQADSPS CCCCCCCCCCCCCCC	41.54	23737553
747	Phosphorylation	LHLPNPSSQADSPSS CCCCCCCCCCCCCCC	30.55	23737553
751	Phosphorylation	NPSSQADSPSSEKSP CCCCCCCCCCCCCCC	29.69	26824392
753	Phosphorylation	SSQADSPSSEKSPGS CCCCCCCCCCCCCCC	55.89	23737553
754	Phosphorylation	SQADSPSSEKSPGST CCCCCCCCCCCCCCC	53.05	23737553
757	Phosphorylation	DSPSSEKSPGSTPFK CCCCCCCCCCCCCCC	30.37	26824392
760	Phosphorylation	SSEKSPGSTPFKFWA CCCCCCCCCCCCCEE	35.97	29472430
761	Phosphorylation	SEKSPGSTPFKFWAW CCCCCCCCCCCCEEC	38.36	19060867
897	Phosphorylation	GGLPEEQSLTPSPSA CCCCCHHCCCCCCCC	37.17	29899451
899	Phosphorylation	LPEEQSLTPSPSANP CCCHHCCCCCCCCCC	27.28	21659605
901	Phosphorylation	EEQSLTPSPSANPEI CHHCCCCCCCCCCCC	26.67	27180971
903	Phosphorylation	QSLTPSPSANPEISV HCCCCCCCCCCCCEE	45.04	23737553
929	S-nitrosylation	AEAGAPHCGTNPQPA HHCCCCCCCCCCCCC	7.57	21278135
929	S-nitrosocysteine	AEAGAPHCGTNPQPA HHCCCCCCCCCCCCC	7.57	-
966	Phosphorylation	KTLALEKTINHQMES CHHHHHHHHCCCCCC	20.03	23527152
973	Phosphorylation	TINHQMESPGERRKS HHCCCCCCCCCCCCC	32.63	25521595
996	Acetylation	SCGLTLGKGAAMIIE HCCCCCCCCHHHHHH	48.79	15606747

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LIMC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LIMC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LIMC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LIMC1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LIMC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; THR-215; SER-217;SER-231 AND SER-719, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-719 ANDSER-973, AND MASS SPECTROMETRY.	16452087 [Abstract]