XIRP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XIRP2_MOUSE
• UniProt AC: Q4U4S6
• Protein Name: Xin actin-binding repeat-containing protein 2
• Gene Name: Xirp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 3784
• Subcellular Localization: Cell junction . Colocalizes with actin stress fibers.
• Protein Description: Protects actin filaments from depolymerization..
• Protein Sequence: MARYQAAVSRGDTRSFSANVMEESDVCTVPGGLAKMKRQFEKDKMTSTCNAFSEYQYRHESRAEQEAIHSSQEIIRRNEQEVSKGHGTDVFKAEMMSHLEKHTEETKQASQFHQYVQETVIDSPEEEELPKVSTKILKEQFEKSAQENFLRSDKETSPPAKCMKIENDIEETLKPSSAVGTSSSYTSTRQRKETSTSSYSNHSLTSTTLAQDNGTPSGKMEEFPPPPPDVCQTPMDVTAFSQSPEFPSPPRRLPMPKDLYSKQRNLYELNRLYRHIHPELRKNLEKDYISEVSEIVSSQINSGNALSADVQKARYVFENTNDSSQKDLNSERENLEWDEILKGEVQSIRWIFENQPLDSINHGSTDEGYTSKGIADQELIAGSDVKYTTWMFETQPIDALGIPSAGTEGNTEKIPELARGDVYTARWMFETRPLDSMNKMHECQEETASTLTKDITGGDVKTVRYMFETQQLDQLGQLHSVDELNLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVQREDIEKGDVRTARWMFETQPLDTINKDITEIKVVRGISMEENVKGGVSRAKWLFETQPLEKIKEESGEAVLKTEAVIGTDVSKKCWMFETQPLDILKDSPDTDSVSPEERIGGDVKTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVKHQKWVFETQRLEDIREDKKEYTRTVRLEAVDRGHVKNYTHIFESNNLIKVDASHQIEVEGVTRGTVELNKSLFETTPLYAIQDHLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESLHKFQIIRGISAQEIQAGNVKSARWLFETQPLDSIKYFSNVEETDSKTEQSTDIVKGDVKTCKWLFETQPMESLYEKASLMTNSEDIHKGDVRTCMWLFETQPLDAIKDDSEATVKLQTVKQEEIQGGDVQTACFLFETENLDNIQGDEGKENKPLEMDIQSGDVSGMKFKFENQSLDSINCSSENVLSKIKTLKAEDIQKGNVLKCRWLFENQPIDMIKESQECDGLVKTVTDVQGGDVRKGCFIFETFSLDEIKDESDGISMRETNLGEIIKGDVKSYKMLFETQPLYAIQDHEGFYHEVTTVKKEETIHGDVRGTRWLFETKPLDSIHESEDVYVIKSVTQEDIQKGDVSSVRYRFETQPLDMISDKSHNIVPTVDYIQGGNVQMNKQLFESEGGNKKNYVRTVSVNEIQKGNVKTSTWLFETHRIDELGEESRYENIKTVTQEDVQKGDVKQAVWLFENQTLDSINELDENDTKMTKEEIPPSDVKTTTWLFETTPIHEFNKTRVEKEEIIGKSIKETLEDLYSQRVVEAPGIIIEADEVGDVRMAKYKLMNQTTPEIQKEEVIRADLGNIMMNLLSQRDCTKKEIFVSEEEKGNVNFTKTQLLNRSMEFHAEKEEIVRGDVKQAIQKLFSEERRAKKGILIQEDEKGDINMTIYCLLHENAGDKTEREDILGGDVRRTIHNLLSSASNGKISERTKIDASERGNVQFFTTCIETGALDYLKQLQTGSNESTLTASKQEGEEEIIGGDVEGTKFLLKKRQSSFERTVSETDIIPGDVRHTVKVFMTEPQSSSYKTVKDEIIKGDLKSTLNSLNQAMNQKTVAKAEEIVKDDRLAILKSLKESGDRQKEPKQSGGMSRDIGQAIECLERATNTRTEILKKELILDDLKTSLRSLKEEQCGFKEVDKQGIVKDVLPGMLGFSERPKIGIHPAAVQRDKKSLLQPVPGPFEPAIKQQAGPGTLDETTQKPCLRSLIEERTEANLPKAPKGTVKIVIDREQNNDALEKSLRKMSNSEHRAMKNVLDMSDRMGIWTESKEYLCSDDHMSKHLSATMSIKESLKSKESENMREAKDDVISSTQSVDKTFRKQQTQTCELGNDQKSRFQDSYGKNQKNIQNIEITRDFQKQALLSQEKQYSNKEMKKNEASLQPLPVGKEVHSVPGVTVSGKNHKRIQATDKRQKTDVCLESQDFLMKTNTSKELKMAMERSFNPINLHPECGIKENEDSLPPPSPPPLPPSNASSEIEFPLPPPPPLMLLPGKNESPPSSPTEKTRTEFESLSTLPLPPPPVDEKAEQECLSTTLPPPPPPTPCQPGHLLPSSVLGHHREAFLQQFSQKEALGVHLPHSQAKILTGKSPPPTLPKPKLPKRIKDKMNQYSSSGELERSLSDVEIKATLSKDQKRSMVTMSSEHRETKQDVFGKGLVGRKQLPVDSANSLSQTVPEIPAPKEKQTAPLVKSHSFPSGSEQQSPKPYMRKFKTPLMIAEEKYRQQREELEKQRQESSSHNVIKTETQHQSLSEKEEEIELQKATEAISTPRKESDFPRARPNLDSESRAVIAGECSESQLATASTLTVATERLQHVLAASEDELTLRQEGIQNSSDASQSKLACETSQSHKECKAQQTFEQHVKRLPFPQTKPSSPSFKVKTIKLSTLDHTGTETDLSSKHHTKQSEVDIQTSTEQTDKEIKKTQASIQCDDKPSVPEKYFQLPKTEKRVTIQMPKEYAEKSHKSKLQTVPKKQGIFGEFDRGNVLGREGKNQDSSVSCSKEDRLIDERKQEHLQNQRVPRSVQQKVINERLDSQMQNFQQTEIQTSRSTIECEEFSQSYNATQEKTCLKDKGKQQGQVTSNTEESKQELRQNQSAFSSVKDSQHDDGKCTINILEFLRKREELQQILSRVKQFEAESSKSGLKTFQILLNIVPVWLISEEKREYGVRVAMENNFEKVKEEITHIKTQAEEMLLQCEHVIQTAMMASQTGKQRDKPTNLNEMPLNVSNVNLSSSKCTEQKESKTVEEKLTHRQVTTHPEAATRNPVKPYQEAKGEDGKMAPPSLKTRPPSPTFITIESTARRAETSTKSELSQSPKNNRCIEPPPRRPVEHASGLPRSRTPPSPPRSRSEQLVRLKDTTARLAKGTIPCSPGTPVPIVEKRSEVVMSPATLRRQIKIESRGGDSPPTITIPVSVNHVVSGSFRESVDAQEAVKKTEKTETYVHKDKMNSVNRAMPETESYDAVEIIRKVEGPHLSEHTERFEATNQTVQRAERFLNGHENEINRWFREFENDPVFRAKTERGAYANGEINHNMKQESHTFCKEEFGLASSETANFTGFSYRHPKVPAMQPRVHSEARSLNEHFSSVDAFDSQIVGSKVATSSSRSTEAGRSGFDFKHAPPTYEDVISGHILDVADSPTNLRRNFQKTWQESERVFQRVGYETSDAHATEMSRAFQEESAFLSDKEICIICQKTVYPMECLIADKQNFHKSCFRCHHCSSKLSLGNYASLHGRIYCKPHFKQLFKSKGNYDEGFGHKQHKDRWNCKNQSSLVDFIPSGEPDAHENPTADTLLLGDLTTHPDACNSKRQDNDLRKWGDRGKLKIVWPPCQEMPKKNSPPEEEFKVNKAKWPPEVTIPVPSDFKRESLTEHVKTLESQGQEQDSVPDLQPCKHVCQKEDITGIKEIKGYEERKDEKEAKDTLKDAEGLRSKRKSGMEFNDHNAHAQSDGKEKNALVNEADSADVLQVANTDDEGGPENHRENFNNNNNNSVAVSSLNNGRQKISISERPRLLQAVSEANYYTSEYQIKNFNNASKISELLGIFESQKLSSKKVLALALERTADRGTAGSPLQLVLEPGLQQGFSVKGENLAASPDVSPLHIKGNHENNKNVHLFFSNTVKITSFSKKHNILGCDLMDSVDQLKNMSCLYLRELGKNVKCWHGETAGAARHGGKMCFDAQSQGSAAKPVFPSMQCQAQHLTVEEQIKRDRCYSDSEAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	AEQEAIHSSQEIIRR HHHHHHHHHHHHHHH	27.83	27742792
71	Phosphorylation	EQEAIHSSQEIIRRN HHHHHHHHHHHHHHC	20.05	27742792
97	Phosphorylation	VFKAEMMSHLEKHTE HHHHHHHHHHHHHHH	24.49	27841257
123	Phosphorylation	VQETVIDSPEEEELP HHHHHCCCCCHHHCC	24.08	22817900
176	Phosphorylation	IEETLKPSSAVGTSS HHHHCCCCCCCCCCC	29.37	22871156
182	Phosphorylation	PSSAVGTSSSYTSTR CCCCCCCCCCCCCCC	16.03	22871156
188	Phosphorylation	TSSSYTSTRQRKETS CCCCCCCCCCCCCCC	24.03	22871156
359	Phosphorylation	FENQPLDSINHGSTD CCCCCCCCCCCCCCC	32.73	23737553
364	Phosphorylation	LDSINHGSTDEGYTS CCCCCCCCCCCCCCC	25.74	23737553
365	Phosphorylation	DSINHGSTDEGYTSK CCCCCCCCCCCCCCC	42.54	23737553
370	Phosphorylation	GSTDEGYTSKGIADQ CCCCCCCCCCCCCCC	34.52	23737553
371	Phosphorylation	STDEGYTSKGIADQE CCCCCCCCCCCCCCE	22.02	23737553
436	Phosphorylation	FETRPLDSMNKMHEC EECCCCCHHHCHHHH	31.75	22817900
519	Phosphorylation	LYVIRDGSGQMLEIK EEEEECCCCCEEEEE	30.09	27742792
567	Phosphorylation	IKVVRGISMEENVKG EEEEECCCCCHHCCC	23.98	23737553
628	Phosphorylation	PLDILKDSPDTDSVS CHHHHCCCCCCCCCC	24.08	27742792
631	Phosphorylation	ILKDSPDTDSVSPEE HHCCCCCCCCCCHHH	33.29	27742792
633	Phosphorylation	KDSPDTDSVSPEERI CCCCCCCCCCHHHHC	26.96	23737553
635	Phosphorylation	SPDTDSVSPEERIGG CCCCCCCCHHHHCCC	30.46	23737553
815	Phosphorylation	FQIIRGISAQEIQAG CCEECCCCHHHHHCC	27.07	23737553
825	Ubiquitination	EIQAGNVKSARWLFE HHHCCCCCCCEEEEE	42.26	22790023
841	Phosphorylation	QPLDSIKYFSNVEET CCCCCEEEECCCHHC	15.57	17203969
843	Phosphorylation	LDSIKYFSNVEETDS CCCEEEECCCHHCCC	36.55	17203969
879	Phosphorylation	TQPMESLYEKASLMT CCCCHHHHHHHHCCC	25.35	29899451
966	Phosphorylation	PLEMDIQSGDVSGMK CCCEEECCCCCCCCE	36.98	28464351
983	Phosphorylation	FENQSLDSINCSSEN ECCCCCCCCCCCCHH	22.46	28464351
1071	Phosphorylation	DGISMRETNLGEIIK CCCCCCCCCHHHHHH	25.94	24719451
1147	Phosphorylation	VYVIKSVTQEDIQKG EEEEEEECHHHHHCC	33.07	28464351
1199	Phosphorylation	MNKQLFESEGGNKKN CCHHHEECCCCCCCC	33.92	28059163
1210	Phosphorylation	NKKNYVRTVSVNEIQ CCCCEEEEEECCHHH	13.69	27742792
1212	Phosphorylation	KNYVRTVSVNEIQKG CCEEEEEECCHHHCC	20.72	23737553
1242	Phosphorylation	ELGEESRYENIKTVT CCCHHHHHHCCEECC	23.70	26745281
1247	Phosphorylation	SRYENIKTVTQEDVQ HHHHCCEECCHHHHH	25.62	26745281
1249	Phosphorylation	YENIKTVTQEDVQKG HHCCEECCHHHHHCC	31.32	26745281
1269	Phosphorylation	VWLFENQTLDSINEL HHHEECCCHHHHHHC	44.08	28494245
1281	Phosphorylation	NELDENDTKMTKEEI HHCCCCCCCCCCCCC	34.01	28494245
1363	Phosphorylation	YKLMNQTTPEIQKEE HHHHCCCCHHHHHHH	14.79	21659604
1415	Phosphorylation	KTQLLNRSMEFHAEK HHHHHHHHHHHHHCH	22.91	27742792
1439	Phosphorylation	QAIQKLFSEERRAKK HHHHHHHHHHHHHHC	49.32	22817900
1496	Phosphorylation	HNLLSSASNGKISER HHHHHHHCCCCCCCC	48.33	28464351
1536	Phosphorylation	LKQLQTGSNESTLTA HHHHCCCCCCCCEEE	40.59	27742792
1539	Phosphorylation	LQTGSNESTLTASKQ HCCCCCCCCEEECCC	32.73	26060331
1540	Phosphorylation	QTGSNESTLTASKQE CCCCCCCCEEECCCC	23.19	26060331
1542	Phosphorylation	GSNESTLTASKQEGE CCCCCCEEECCCCCC	29.04	26060331
1544	Phosphorylation	NESTLTASKQEGEEE CCCCEEECCCCCCCE	29.63	26060331
1569	Phosphorylation	FLLKKRQSSFERTVS HHHHHCCCCCCCCCC	40.82	23737553
1570	Phosphorylation	LLKKRQSSFERTVSE HHHHCCCCCCCCCCC	23.84	23737553
1574	Phosphorylation	RQSSFERTVSETDII CCCCCCCCCCCCCCC	22.61	27742792
1576	Phosphorylation	SSFERTVSETDIIPG CCCCCCCCCCCCCCC	33.88	23737553
1578	Phosphorylation	FERTVSETDIIPGDV CCCCCCCCCCCCCCC	25.62	27742792
1697	Phosphorylation	ILDDLKTSLRSLKEE HHHHHHHHHHHHHHH	21.87	21183079
1779	Phosphorylation	TQKPCLRSLIEERTE HCCHHHHHHHHHHHH	22.28	23737553
1860	Phosphorylation	KHLSATMSIKESLKS HHHHHHHHHHHHHHC	26.59	21183079
1886	Phosphorylation	DVISSTQSVDKTFRK HHHHHCHHHCHHHHH	32.16	28464351
1896	Phosphorylation	KTFRKQQTQTCELGN HHHHHHHCCEECCCC	24.29	28464351
1936	Phosphorylation	FQKQALLSQEKQYSN HHHHHHHHHHHHHCC	36.82	21659604
1941	Phosphorylation	LLSQEKQYSNKEMKK HHHHHHHHCCHHHHH	25.86	25338131
1942	Phosphorylation	LSQEKQYSNKEMKKN HHHHHHHCCHHHHHC	38.64	25338131
1987	Phosphorylation	ATDKRQKTDVCLESQ CCCCCCCCCHHHHHH	25.90	30482847
1993	Phosphorylation	KTDVCLESQDFLMKT CCCHHHHHHHCHHHC	23.31	30482847
2068	Phosphorylation	LLPGKNESPPSSPTE CCCCCCCCCCCCCCC	52.05	23737553
2071	Phosphorylation	GKNESPPSSPTEKTR CCCCCCCCCCCCCCC	52.94	23737553
2072	Phosphorylation	KNESPPSSPTEKTRT CCCCCCCCCCCCCCC	41.43	23737553
2074	Phosphorylation	ESPPSSPTEKTRTEF CCCCCCCCCCCCCCC	52.65	23737553
2139	Phosphorylation	EAFLQQFSQKEALGV HHHHHHHHHHHHHCC	35.68	27742792
2182	Phosphorylation	KDKMNQYSSSGELER HHHHHHCCCCCHHHH	14.31	23737553
2183	Phosphorylation	DKMNQYSSSGELERS HHHHHCCCCCHHHHH	37.11	23737553
2184	Phosphorylation	KMNQYSSSGELERSL HHHHCCCCCHHHHHH	30.28	23737553
2190	Phosphorylation	SSGELERSLSDVEIK CCCHHHHHHHHHHHE	23.89	27742792
2192	Phosphorylation	GELERSLSDVEIKAT CHHHHHHHHHHHEEE	40.64	23737553
2262	Phosphorylation	QTAPLVKSHSFPSGS CCCCCEECCCCCCCC	19.51	27742792
2264	Phosphorylation	APLVKSHSFPSGSEQ CCCEECCCCCCCCCC	46.04	27742792
2267	Phosphorylation	VKSHSFPSGSEQQSP EECCCCCCCCCCCCC	53.60	27742792
2269	Phosphorylation	SHSFPSGSEQQSPKP CCCCCCCCCCCCCCC	36.25	27742792
2273	Phosphorylation	PSGSEQQSPKPYMRK CCCCCCCCCCCCHHH	34.29	27742792
2277	Phosphorylation	EQQSPKPYMRKFKTP CCCCCCCCHHHCCCC	18.71	27742792
2316	Phosphorylation	HNVIKTETQHQSLSE CCCCCHHHHHHCCCH	36.26	27742792
2320	Phosphorylation	KTETQHQSLSEKEEE CHHHHHHCCCHHHHH	31.57	27742792
2322	Phosphorylation	ETQHQSLSEKEEEIE HHHHHCCCHHHHHHH	52.44	27742792
2366	Phosphorylation	AVIAGECSESQLATA EEEEECCCHHHHHCC	35.66	-
2374	Phosphorylation	ESQLATASTLTVATE HHHHHCCHHHHHHHH	21.42	-
2380	Phosphorylation	ASTLTVATERLQHVL CHHHHHHHHHHHHHH	19.80	-
2390	Phosphorylation	LQHVLAASEDELTLR HHHHHHCCCCCHHHH	39.72	23737553
2428	Phosphorylation	KECKAQQTFEQHVKR HHHHHHHHHHHHHHH	19.63	28464351
2444	Phosphorylation	PFPQTKPSSPSFKVK CCCCCCCCCCCCEEE	57.34	23737553
2445	Phosphorylation	FPQTKPSSPSFKVKT CCCCCCCCCCCEEEE	32.84	23737553
2447	Phosphorylation	QTKPSSPSFKVKTIK CCCCCCCCCEEEEEE	39.38	23737553
2456	Phosphorylation	KVKTIKLSTLDHTGT EEEEEEEEECCCCCC	23.17	28464351
2457	Phosphorylation	VKTIKLSTLDHTGTE EEEEEEEECCCCCCC	46.79	-
2483	Phosphorylation	SEVDIQTSTEQTDKE HHCCCCCCCHHHHHH	17.36	25521595
2484	Phosphorylation	EVDIQTSTEQTDKEI HCCCCCCCHHHHHHH	35.18	25521595
2487	Phosphorylation	IQTSTEQTDKEIKKT CCCCCHHHHHHHHHH	42.69	25521595
2497	Phosphorylation	EIKKTQASIQCDDKP HHHHHHHHCCCCCCC	11.90	27742792
2505	Phosphorylation	IQCDDKPSVPEKYFQ CCCCCCCCCCHHHCC	56.92	21183079
2604	Phosphorylation	VINERLDSQMQNFQQ HHHHHHHHHHHHHHH	31.95	30635358
2612	Phosphorylation	QMQNFQQTEIQTSRS HHHHHHHHCHHHCCC	25.03	30635358
2616	Phosphorylation	FQQTEIQTSRSTIEC HHHHCHHHCCCEEEH	31.59	30635358
2617	Phosphorylation	QQTEIQTSRSTIECE HHHCHHHCCCEEEHH	14.09	30635358
2797	Phosphorylation	NEMPLNVSNVNLSSS CCCCCCCCCCCCCCC	33.71	27742792
2802	Phosphorylation	NVSNVNLSSSKCTEQ CCCCCCCCCCCCCCC	27.62	27742792
2803	Phosphorylation	VSNVNLSSSKCTEQK CCCCCCCCCCCCCCC	36.66	27742792
2804	Phosphorylation	SNVNLSSSKCTEQKE CCCCCCCCCCCCCCC	28.51	27742792
2810	Acetylation	SSKCTEQKESKTVEE CCCCCCCCCCCCHHH	58.69	7613103
2813	Acetylation	CTEQKESKTVEEKLT CCCCCCCCCHHHHHH	58.65	7613115
2856	Phosphorylation	MAPPSLKTRPPSPTF CCCCCCCCCCCCCCE	54.42	23737553
2860	Phosphorylation	SLKTRPPSPTFITIE CCCCCCCCCCEEEEE	38.97	23737553
2862	Phosphorylation	KTRPPSPTFITIEST CCCCCCCCEEEEECC	31.82	23737553
2884	Phosphorylation	TKSELSQSPKNNRCI CHHHHCCCCCCCCCC	34.17	23737553
2908	Phosphorylation	HASGLPRSRTPPSPP CCCCCCCCCCCCCCC	38.27	23737553
2910	Phosphorylation	SGLPRSRTPPSPPRS CCCCCCCCCCCCCCC	40.58	23737553
2913	Phosphorylation	PRSRTPPSPPRSRSE CCCCCCCCCCCCCHH	49.06	23737553
2928	Phosphorylation	QLVRLKDTTARLAKG HHHHHHHHHHHHHCC	22.29	24759943
2940	Phosphorylation	AKGTIPCSPGTPVPI HCCCCCCCCCCCCCE	22.47	22817900
2943	Phosphorylation	TIPCSPGTPVPIVEK CCCCCCCCCCCEEEC	25.21	22817900
2952	Phosphorylation	VPIVEKRSEVVMSPA CCEEECCCEEECCHH	45.90	27742792
2957	Phosphorylation	KRSEVVMSPATLRRQ CCCEEECCHHHHHHH	10.36	23737553
2960	Phosphorylation	EVVMSPATLRRQIKI EEECCHHHHHHHEEE	24.96	27742792
2974	Phosphorylation	IESRGGDSPPTITIP EECCCCCCCCEEEEE	35.73	23737553
2989	Phosphorylation	VSVNHVVSGSFRESV EEECEEECCCHHHCC	27.86	19060867
3154	Phosphorylation	RSLNEHFSSVDAFDS HHHHHHCCCCCCCCH	31.21	21183079
3155	Phosphorylation	SLNEHFSSVDAFDSQ HHHHHCCCCCCCCHH	24.07	22817900
3206	Phosphorylation	HILDVADSPTNLRRN CEEECCCCCCHHHHH	24.72	19060867
3208	Phosphorylation	LDVADSPTNLRRNFQ EECCCCCCHHHHHHH	51.33	22210690
3319	Phosphorylation	LFKSKGNYDEGFGHK HHHCCCCCCCCCCCC	24.84	29514104
3468	Phosphorylation	VCQKEDITGIKEIKG HCCCCCCCCHHHCCC	45.21	-
3571	Phosphorylation	NNGRQKISISERPRL CCCCCEECHHHCHHH	27.39	24719451
3573	Phosphorylation	GRQKISISERPRLLQ CCCEECHHHCHHHHH	22.29	23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XIRP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XIRP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XIRP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XIRP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.