RAI14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAI14_MOUSE
• UniProt AC: Q9EP71
• Protein Name: Ankycorbin
• Gene Name: Rai14
• Organism: Mus musculus (Mouse).
• Sequence Length: 979
• Subcellular Localization: Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Cell junction . Nucleus . Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (PubMed:11168586). Highly expressed at the ectoplas
• Protein Description: Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier..
• Protein Sequence: MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLKVMVTHGVDVTAQDSSGHSALHVAAKNGHPECIRKLLQYKSPAENIDNSGKTALHYAAAQGCLQAVQLLCEHKSPINLKDLDGNIPLLVAVQNGHSEACHFLLDHGADVNSRDKNGRTALMLACETGSSNTVDALIKKGADLSLVDSLGHNALHYSKLSENAGIQNLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEAPFKAEISSIQENKDRLSDSTAGADSLLDISSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKSPKDKEAEADLSFQSFHSTQTDLAPSPGKASDIPSSDAKSSPPVEHPAGTSTTDNDVIIRQLQDSLHDLQKRLESSEAEKKQLQDELQSQRTDTLCLNNTEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLLSQESADGYSHLREAPADEDIDTLKQDLQKAVEESARNKERVRELETKLAEKEQAEATKPPAEACEELRSSYCSVIENMNKEKAFLFEKYQQAQEEIMKLKDTLKSQMPQEAPDDSGDMKEAMNRMIDELNKQVSELSQLYREAQAELEDYRKRKSLEDAAEYIHKAEHERLMHVSNLSRAKSEEALSEMKSQYSKVLNELTQLKQLVDAHKENSVSITEHLQVITTLRTTAKEMEEKISALTGHLANKEAEVAKLEKQLAEEKAAVSDAMVPKSSYEKLQASLESEVNALATKLKESVREREKAHSEVAQVRSEVSQARREKDNIQTLLKAKEQEVTALVQKFQRAQEELAGMRRCSETSSKLEEDKDEKINEMTREVLKLKEALNSLSQLSYSTSSSKRQSQQLDLLQQQVKQLQNQLAECKKHHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MKSLKAKF -------CCCHHHHH	6.33	-
11	Phosphorylation	LKAKFRKSDTNEWNK HHHHHCCCCCCCCCC	45.47	26824392
13	Phosphorylation	AKFRKSDTNEWNKND HHHCCCCCCCCCCCC	41.97	26643407
37	Phosphorylation	GDAEKVASLLGKKGA CCHHHHHHHHCCCCC	27.41	26643407
110	Phosphorylation	RKLLQYKSPAENIDN HHHHHCCCHHHHCCC	25.14	21659604
118	Phosphorylation	PAENIDNSGKTALHY HHHHCCCCCHHHHHH	37.61	21659604
212	Phosphorylation	IKKGADLSLVDSLGH HHCCCCCHHHHCCCC	27.22	26370283
239	Phosphorylation	GIQNLLLSKISQDAD CHHHHHHHHHCCCCC	28.10	23984901
242	Phosphorylation	NLLLSKISQDADLKT HHHHHHHCCCCCCCC	26.24	25619855
249	Phosphorylation	SQDADLKTPTKPKQH CCCCCCCCCCCCCCC	43.41	26824392
251	Phosphorylation	DADLKTPTKPKQHDQ CCCCCCCCCCCCCHH	66.27	25619855
263	Phosphorylation	HDQVSKISSERSGTP CHHHHHHCCCCCCCC	29.86	25338131
264	Phosphorylation	DQVSKISSERSGTPK HHHHHHCCCCCCCCC	40.27	25338131
269	Phosphorylation	ISSERSGTPKKRKAP HCCCCCCCCCCCCCC	32.93	23384938
281	Phosphorylation	KAPPPPISPTQLSDV CCCCCCCCCCCHHCC	27.89	27087446
283	Phosphorylation	PPPPISPTQLSDVSS CCCCCCCCCHHCCCC	35.04	25619855
286	Phosphorylation	PISPTQLSDVSSPRS CCCCCCHHCCCCCCC	26.58	25619855
289	Phosphorylation	PTQLSDVSSPRSITS CCCHHCCCCCCCCCC	39.35	25619855
290	Phosphorylation	TQLSDVSSPRSITST CCHHCCCCCCCCCCC	24.95	25619855
293	Phosphorylation	SDVSSPRSITSTPLS HCCCCCCCCCCCCCC	33.33	25521595
295	Phosphorylation	VSSPRSITSTPLSGK CCCCCCCCCCCCCCC	28.00	25521595
296	Phosphorylation	SSPRSITSTPLSGKE CCCCCCCCCCCCCCC	26.76	20469934
297	Phosphorylation	SPRSITSTPLSGKES CCCCCCCCCCCCCCC	21.43	25521595
300	Phosphorylation	SITSTPLSGKESVFF CCCCCCCCCCCCEEE	49.36	25521595
302	Ubiquitination	TSTPLSGKESVFFAE CCCCCCCCCCEEEEE	43.36	-
304	Phosphorylation	TPLSGKESVFFAEAP CCCCCCCCEEEEECC	27.92	26824392
317	Phosphorylation	APFKAEISSIQENKD CCCHHHHHHHHHCCC	16.94	22324799
318	Phosphorylation	PFKAEISSIQENKDR CCHHHHHHHHHCCCC	33.67	25521595
327	Phosphorylation	QENKDRLSDSTAGAD HHCCCCCCCCCCCCC	30.34	27087446
329	Phosphorylation	NKDRLSDSTAGADSL CCCCCCCCCCCCCHH	19.44	26643407
330	Phosphorylation	KDRLSDSTAGADSLL CCCCCCCCCCCCHHH	33.82	25293948
335	Phosphorylation	DSTAGADSLLDISSE CCCCCCCHHHCCCCC	30.23	30352176
340	Phosphorylation	ADSLLDISSEADQQD CCHHHCCCCCCCHHH	23.07	26824392
341	Phosphorylation	DSLLDISSEADQQDL CHHHCCCCCCCHHHH	36.82	26643407
358	Phosphorylation	LLQAKVASLTLHNKE HHHHHHHHHHCCCHH	25.52	26824392
360	Phosphorylation	QAKVASLTLHNKELQ HHHHHHHHCCCHHHH	24.39	26643407
374	Phosphorylation	QDKLQAKSPKDKEAE HHHHHHCCCCCHHHH	39.95	26824392
388	Phosphorylation	EADLSFQSFHSTQTD HHHCCHHCHHCCCCC	23.94	26160508
391	Phosphorylation	LSFQSFHSTQTDLAP CCHHCHHCCCCCCCC	21.87	26160508
392	Phosphorylation	SFQSFHSTQTDLAPS CHHCHHCCCCCCCCC	27.24	26160508
394	Phosphorylation	QSFHSTQTDLAPSPG HCHHCCCCCCCCCCC	32.82	26160508
399	Phosphorylation	TQTDLAPSPGKASDI CCCCCCCCCCCHHHC	40.45	25619855
404	Phosphorylation	APSPGKASDIPSSDA CCCCCCHHHCCCCCC	39.29	26160508
408	Phosphorylation	GKASDIPSSDAKSSP CCHHHCCCCCCCCCC	40.98	26239621
409	Phosphorylation	KASDIPSSDAKSSPP CHHHCCCCCCCCCCC	35.91	26239621
413	Phosphorylation	IPSSDAKSSPPVEHP CCCCCCCCCCCCCCC	50.20	27087446
414	Phosphorylation	PSSDAKSSPPVEHPA CCCCCCCCCCCCCCC	32.30	25521595
423	Phosphorylation	PVEHPAGTSTTDNDV CCCCCCCCCCCCCHH	25.63	26239621
424	Phosphorylation	VEHPAGTSTTDNDVI CCCCCCCCCCCCHHH	28.52	26239621
425	Phosphorylation	EHPAGTSTTDNDVII CCCCCCCCCCCHHHH	37.70	26239621
426	Phosphorylation	HPAGTSTTDNDVIIR CCCCCCCCCCHHHHH	32.35	26239621
438	Phosphorylation	IIRQLQDSLHDLQKR HHHHHHHHHHHHHHH	18.03	26824392
444	Ubiquitination	DSLHDLQKRLESSEA HHHHHHHHHHHCCHH	67.27	22790023
448	Phosphorylation	DLQKRLESSEAEKKQ HHHHHHHCCHHHHHH	37.76	26824392
449	Phosphorylation	LQKRLESSEAEKKQL HHHHHHCCHHHHHHH	31.30	26824392
454	Ubiquitination	ESSEAEKKQLQDELQ HCCHHHHHHHHHHHH	47.98	22790023
476	Phosphorylation	CLNNTEISENGSDLS ECCCCCCCCCCCHHH	20.83	21659604
505	Ubiquitination	KEVLSVQKQMKLGLL HHHHHHHHHHHHCCC	50.64	22790023
508	Ubiquitination	LSVQKQMKLGLLSQE HHHHHHHHHCCCCHH	36.59	22790023
513	Phosphorylation	QMKLGLLSQESADGY HHHHCCCCHHCCCCC	36.62	26643407
516	Phosphorylation	LGLLSQESADGYSHL HCCCCHHCCCCCHHH	24.83	25521595
520	Phosphorylation	SQESADGYSHLREAP CHHCCCCCHHHHCCC	8.08	26239621
521	Phosphorylation	QESADGYSHLREAPA HHCCCCCHHHHCCCC	22.90	23984901
546	Phosphorylation	LQKAVEESARNKERV HHHHHHHHHHHHHHH	21.01	28059163
627	Phosphorylation	PQEAPDDSGDMKEAM CCCCCCCCHHHHHHH	44.03	26643407
667	Phosphorylation	EDYRKRKSLEDAAEY HHHHHHCCHHHHHHH	40.81	27818261
694	Phosphorylation	SNLSRAKSEEALSEM HCHHHHCCHHHHHHH	39.42	26824392
907	Phosphorylation	LSQLSYSTSSSKRQS HHHHHCCCCCCHHHH	25.13	26643407
908	Phosphorylation	SQLSYSTSSSKRQSQ HHHHCCCCCCHHHHH	27.03	26643407
909	Phosphorylation	QLSYSTSSSKRQSQQ HHHCCCCCCHHHHHH	39.71	26643407
910	Phosphorylation	LSYSTSSSKRQSQQL HHCCCCCCHHHHHHH	31.46	26643407
911	Ubiquitination	SYSTSSSKRQSQQLD HCCCCCCHHHHHHHH	57.30	-
914	Phosphorylation	TSSSKRQSQQLDLLQ CCCCHHHHHHHHHHH	24.75	26824392
935	Acetylation	QNQLAECKKHHQEVI HHHHHHHHHHHHHHH	46.80	23864654
936	Acetylation	NQLAECKKHHQEVIS HHHHHHHHHHHHHHH	58.96	7618155

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
249	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAI14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAI14_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.