THIO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THIO_MOUSE
• UniProt AC: P10639
• Protein Name: Thioredoxin
• Gene Name: Txn
• Organism: Mus musculus (Mouse).
• Sequence Length: 105
• Subcellular Localization: Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm
• Protein Description: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).; ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55)..
• Protein Sequence: MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEASITEYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Malonylation	-----MVKLIESKEA -----CCEECCCHHH	42.31	26320211
3	Acetylation	-----MVKLIESKEA -----CCEECCCHHH	42.31	23201123
8	Acetylation	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	22826441
8	Succinylation	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	-
8	Ubiquitination	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	-
8	Succinylation	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	23806337
28	Phosphorylation	KLVVVDFSATWCGPC CEEEEECCCCCCCCH	21.96	26643407
30	Phosphorylation	VVVDFSATWCGPCKM EEEECCCCCCCCHHH	21.79	26643407
39	Malonylation	CGPCKMIKPFFHSLC CCCHHHHHHHHHHHH	32.07	26320211
39	Acetylation	CGPCKMIKPFFHSLC CCCHHHHHHHHHHHH	32.07	23806337
39	Succinylation	CGPCKMIKPFFHSLC CCCHHHHHHHHHHHH	32.07	23806337
39	Ubiquitination	CGPCKMIKPFFHSLC CCCHHHHHHHHHHHH	32.07	-
44	Phosphorylation	MIKPFFHSLCDKYSN HHHHHHHHHHHHCCC	26.07	29514104
62	S-nitrosocysteine	LEVDVDDCQDVAADC EEEECCCHHHHHHCC	3.01	-
62	S-nitrosylation	LEVDVDDCQDVAADC EEEECCCHHHHHHCC	3.01	-
69	S-nitrosocysteine	CQDVAADCEVKCMPT HHHHHHCCEEEEECC	5.77	-
69	S-nitrosylation	CQDVAADCEVKCMPT HHHHHHCCEEEEECC	5.77	-
73	S-palmitoylation	AADCEVKCMPTFQFY HHCCEEEEECCEEEE	4.82	26165157
73	Glutathionylation	AADCEVKCMPTFQFY HHCCEEEEECCEEEE	4.82	24333276
73	S-nitrosylation	AADCEVKCMPTFQFY HHCCEEEEECCEEEE	4.82	20925432
73	S-nitrosocysteine	AADCEVKCMPTFQFY HHCCEEEEECCEEEE	4.82	-
81	Acetylation	MPTFQFYKKGQKVGE ECCEEEEECCCEEEC	52.28	23201123
85	Acetylation	QFYKKGQKVGEFSGA EEEECCCEEECCCCC	61.96	23806337
85	Succinylation	QFYKKGQKVGEFSGA EEEECCCEEECCCCC	61.96	23806337
85	Ubiquitination	QFYKKGQKVGEFSGA EEEECCCEEECCCCC	61.96	27667366
85	Malonylation	QFYKKGQKVGEFSGA EEEECCCEEECCCCC	61.96	26320211
90	Phosphorylation	GQKVGEFSGANKEKL CCEEECCCCCCHHHH	32.47	22324799
94	Ubiquitination	GEFSGANKEKLEASI ECCCCCCHHHHHHHH	56.54	27667366
94	Succinylation	GEFSGANKEKLEASI ECCCCCCHHHHHHHH	56.54	23806337
94	Malonylation	GEFSGANKEKLEASI ECCCCCCHHHHHHHH	56.54	26320211
94	Succinylation	GEFSGANKEKLEASI ECCCCCCHHHHHHHH	56.54	-
94	Acetylation	GEFSGANKEKLEASI ECCCCCCHHHHHHHH	56.54	23806337
96	Ubiquitination	FSGANKEKLEASITE CCCCCHHHHHHHHEE	53.92	-
96	Acetylation	FSGANKEKLEASITE CCCCCHHHHHHHHEE	53.92	22733758

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THIO_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THIO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THIO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DTBP1_MOUSE	Dtnbp1	physical	14688250

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.