DTBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DTBP1_MOUSE
• UniProt AC: Q91WZ8
• Protein Name: Dysbindin
• Gene Name: Dtnbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 352
• Subcellular Localization: Isoform 1: Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse
• Protein Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway..
• Protein Sequence: MLETLRERLLSVQQDFTSGLKTLSDKSREAKVKGKPRTAPRLPKYSAGLELLSRYEDAWAALHRRAKECADAGELVDSEVVMLSAHWEKKRTSLNELQGQLQQLPALLQDLESLMASLAHLETSFEEVENHLLHLEDLCGQCELERHKQAQAQHLESYKKSKRKELEAFKAELDTEHTQKALEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPMGSMSSMEVNVDVLEQMDLMDISDQEALDVFLNSGGEDNIVMSPGVEMESNPNQNEMSLQIPSPSESASQPPASPSACTDLDTADAPLIQSDEEEVQVDTALVTLHTDRKSTPGVSDDSDQCDSTQDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TLRERLLSVQQDFTS HHHHHHHHHHHHHHH	23.59	26824392
315	Phosphorylation	ADAPLIQSDEEEVQV CCCCCCCCCCHHEEC	39.74	-
335	Phosphorylation	TLHTDRKSTPGVSDD EEECCCCCCCCCCCC	40.50	25619855
336	Phosphorylation	LHTDRKSTPGVSDDS EECCCCCCCCCCCCC	27.39	25619855
340	Phosphorylation	RKSTPGVSDDSDQCD CCCCCCCCCCCHHCC	41.43	27087446
343	Phosphorylation	TPGVSDDSDQCDSTQ CCCCCCCCHHCCCCC	34.27	27087446
348	Phosphorylation	DDSDQCDSTQDI--- CCCHHCCCCCCC---	35.28	25619855
349	Phosphorylation	DSDQCDSTQDI---- CCHHCCCCCCC----	19.60	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Trim32	Q8CH72	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DTBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DTBP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.