COPD_MOUSE - dbPTM
COPD_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COPD_MOUSE
UniProt AC Q5XJY5
Protein Name Coatomer subunit delta
Gene Name Arcn1
Organism Mus musculus (Mouse).
Sequence Length 511
Subcellular Localization Cytoplasm. Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane
Peripheral membrane protein
Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
Protein Description The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)..
Protein Sequence MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKAPGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIMSSNMGKRTSEATKVHAPPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRISDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESGNGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIPGQPNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56PhosphorylationVETESVRYVYQPMEK
EEECCEEEEECCHHH		11.0122817900
65PhosphorylationYQPMEKLYMVLITTK
ECCHHHEEEEEEEEC		9.0322817900
71PhosphorylationLYMVLITTKNSNILE
EEEEEEEECCCCHHH		22.6419854140
138PhosphorylationRTFTEMDSHEEKVFR
EEEECCCCHHHHHHH		31.3324719451
142UbiquitinationEMDSHEEKVFRAVRE
CCCCHHHHHHHHHHH		43.6322790023
142AcetylationEMDSHEEKVFRAVRE
CCCCHHHHHHHHHHH		43.6323236377
164MalonylationAEMRRKAKELQQARR
HHHHHHHHHHHHHHH		63.0926320211
188PhosphorylationPGFGGFGSSAVSGGS
CCCCCCCCCCCCCCC		16.9221082442
192PhosphorylationGFGSSAVSGGSTAAM
CCCCCCCCCCCHHEE		36.8322817900
195PhosphorylationSSAVSGGSTAAMITE
CCCCCCCCHHEEEEE		20.5623984901
196PhosphorylationSAVSGGSTAAMITET
CCCCCCCHHEEEEEE		23.0123984901
201PhosphorylationGSTAAMITETIIETD
CCHHEEEEEEHHHCC		17.6223984901
203PhosphorylationTAAMITETIIETDKP
HHEEEEEEHHHCCCC		20.7123984901
207PhosphorylationITETIIETDKPKVAP
EEEEHHHCCCCCCCC		38.6323984901
220PhosphorylationAPAPARPSGPSKALK
CCCCCCCCCCCCCCC		58.7529895711
223PhosphorylationPARPSGPSKALKLGA
CCCCCCCCCCCCCCC		33.8024719451
224UbiquitinationARPSGPSKALKLGAK
CCCCCCCCCCCCCCC		61.9527667366
224MalonylationARPSGPSKALKLGAK
CCCCCCCCCCCCCCC		61.9526320211
227MalonylationSGPSKALKLGAKGKE
CCCCCCCCCCCCCCC		50.1326320211
233AcetylationLKLGAKGKEVDNFVD
CCCCCCCCCCHHHHH		54.5823806337
233UbiquitinationLKLGAKGKEVDNFVD
CCCCCCCCCCHHHHH		54.5822790023
241AcetylationEVDNFVDKLKSEGET
CCHHHHHHHHHHCCC		53.1423806337
241UbiquitinationEVDNFVDKLKSEGET
CCHHHHHHHHHHCCC		53.1422790023
243UbiquitinationDNFVDKLKSEGETIM
HHHHHHHHHHCCCEE		52.8022790023
244PhosphorylationNFVDKLKSEGETIMS
HHHHHHHHHCCCEEC		62.3625338131
256UbiquitinationIMSSNMGKRTSEATK
EECCCCCCCCCCCCC		41.56-
256MalonylationIMSSNMGKRTSEATK
EECCCCCCCCCCCCC		41.5626320211
259PhosphorylationSNMGKRTSEATKVHA
CCCCCCCCCCCCCCC		29.3024719451
286GlutathionylationEEKITLTCGRDGGLQ
EEEEEEEECCCCCCC		4.7824333276
286S-nitrosylationEEKITLTCGRDGGLQ
EEEEEEEECCCCCCC		4.7820925432
286S-nitrosocysteineEEKITLTCGRDGGLQ
EEEEEEEECCCCCCC		4.78-
309UbiquitinationMLRISDDKFGRIRLH
EEEECCCCCCEEEEE		55.5022790023
309AcetylationMLRISDDKFGRIRLH
EEEECCCCCCEEEEE		55.50-
322UbiquitinationLHVENEDKKGVQLQT
EEEECCCCCCCCCCC		45.29-
329PhosphorylationKKGVQLQTHPNVDKK
CCCCCCCCCCCCCHH		48.14-
335MalonylationQTHPNVDKKLFTAES
CCCCCCCHHCEEHHH		47.2826073543
335AcetylationQTHPNVDKKLFTAES
CCCCCCCHHCEEHHH		47.2823201123
336UbiquitinationTHPNVDKKLFTAESL
CCCCCCHHCEEHHHH		44.3522790023
342PhosphorylationKKLFTAESLIGLKNP
HHCEEHHHHHCCCCC		23.8722802335
347UbiquitinationAESLIGLKNPEKSFP
HHHHHCCCCCCCCCC		66.3022790023
351UbiquitinationIGLKNPEKSFPVNSD
HCCCCCCCCCCCCCC		59.6727667366
351AcetylationIGLKNPEKSFPVNSD
HCCCCCCCCCCCCCC		59.6723806337
351SuccinylationIGLKNPEKSFPVNSD
HCCCCCCCCCCCCCC		59.6723806337
363AcetylationNSDVGVLKWRLQTTE
CCCCCEEEEEEEECC		28.0622826441
363MalonylationNSDVGVLKWRLQTTE
CCCCCEEEEEEEECC		28.0626320211
441S-nitrosylationRRNTLEWCLPVIDAK
CCCCEEEEEEEEECC		1.9420925432
441S-nitrosocysteineRRNTLEWCLPVIDAK
CCCCEEEEEEEEECC		1.94-
448UbiquitinationCLPVIDAKNKSGSLE
EEEEEECCCCCCCEE		62.2522790023
450UbiquitinationPVIDAKNKSGSLEFS
EEEECCCCCCCEEEE		56.33-
479S-nitrosylationFISKKNYCNIQVTKV
EEECCCCEEEEEEEE		5.1721278135
479S-nitrosocysteineFISKKNYCNIQVTKV
EEECCCCEEEEEEEE		5.17-
485UbiquitinationYCNIQVTKVTQVDGN
CEEEEEEEEEEECCC		44.4122790023
487PhosphorylationNIQVTKVTQVDGNSP
EEEEEEEEEECCCCC		25.1629899451
493PhosphorylationVTQVDGNSPVRFSTE
EEEECCCCCEEEEEE		30.2425521595
498PhosphorylationGNSPVRFSTETTFLV
CCCCEEEEEEEEEEE		18.1226745281
499PhosphorylationNSPVRFSTETTFLVD
CCCEEEEEEEEEEEE		34.3426745281
501PhosphorylationPVRFSTETTFLVDKY
CEEEEEEEEEEEEEE		23.9626745281
502PhosphorylationVRFSTETTFLVDKYE
EEEEEEEEEEEEEEE		14.5626745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COPD_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COPD_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COPD_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of COPD_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COPD_MOUSE

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Related Literatures of Post-Translational Modification

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