VPS29_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS29_MOUSE
• UniProt AC: Q9QZ88
• Protein Name: Vacuolar protein sorting-associated protein 29
• Gene Name: Vps29
• Organism: Mus musculus (Mouse).
• Sequence Length: 182
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane ; Peripheral membrane protein .
• Protein Description: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates or a phosphorylated peptide derived from retromer cargo (in vitro). [PubMed: 21629666]
• Protein Sequence: MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Malonylation	SLPAKFKKLLVPGKI CCCHHHHHHCCCCCC	50.62	26320211
28 (in isoform 2)	Malonylation	-	38.03	26320211
43	Acetylation	CTGNLCTKESYDYLK ECCCCCCHHHHHHHH	43.60	22826441
46	Phosphorylation	NLCTKESYDYLKTLA CCCCHHHHHHHHHHC	15.08	25195567
50	Acetylation	KESYDYLKTLAGDVH HHHHHHHHHHCCCEE	34.95	23236377
50	Ubiquitination	KESYDYLKTLAGDVH HHHHHHHHHHCCCEE	34.95	22790023
69	Phosphorylation	DFDENLNYPEQKVVT CCCCCCCCCCCEEEE	16.00	-
73	Acetylation	NLNYPEQKVVTVGQF CCCCCCCEEEEEEEE	36.69	23236377
73	Ubiquitination	NLNYPEQKVVTVGQF CCCCCCCEEEEEEEE	36.69	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS29_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS29_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS29_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS29_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.