MRE11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRE11_MOUSE
• UniProt AC: Q61216
• Protein Name: Double-strand break repair protein MRE11
• Gene Name: Mre11
• Organism: Mus musculus (Mouse).
• Sequence Length: 706
• Subcellular Localization: Nucleus . Chromosome, telomere . Localizes to discrete nuclear foci after treatment with genotoxic agents.
• Protein Description: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation..
• Protein Sequence: MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEVISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKNEQQLFYVSQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGMLITKPASEGATLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSETSTSAFSAEDLSFDTSEQTANDSDDSLSAVPSRGRGRGRGRRGARGQSSAPRGGSQRGRDTGLEITTRGRSSKATSSTSRNMSIIDAFRSTRQQPSRNVAPKNYSETIEVDDSDEDDIFPTNSRADQRWSGTTSSKRMSQSQTAKGVDFESDEDDDDDPFMSSSCPRRNRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSPTDPLDD ------CCCCCCCCC	36.19	-
2	Phosphorylation	------MSPTDPLDD ------CCCCCCCCC	36.19	25521595
4	Phosphorylation	----MSPTDPLDDED ----CCCCCCCCCHH	42.83	27149854
12	Phosphorylation	DPLDDEDTFKILVAT CCCCCHHHHHEEEEE	25.44	25619855
196	Acetylation	LYRMFVNKKVTMLRP HHHHHCCCEEEEECC	43.23	7305595
197	Acetylation	YRMFVNKKVTMLRPK HHHHCCCEEEEECCC	37.42	7305607
275	Phosphorylation	SSVVTSLSPGEAVKK CEEEEECCCHHHHHH	30.53	-
443	Ubiquitination	QYFQTAEKNVQLSLL HHHHHHHHHHHHHHH	61.01	-
618	Phosphorylation	SSTSRNMSIIDAFRS CCCCCCHHHHHHHHH	21.68	26239621
639	Phosphorylation	RNVAPKNYSETIEVD CCCCCCCCCCCEECC	17.63	25619855
640	Phosphorylation	NVAPKNYSETIEVDD CCCCCCCCCCEECCC	37.34	25619855
642	Phosphorylation	APKNYSETIEVDDSD CCCCCCCCEECCCCC	19.25	25619855
648	Phosphorylation	ETIEVDDSDEDDIFP CCEECCCCCCCCCCC	38.14	27087446
665	Phosphorylation	SRADQRWSGTTSSKR CCCCCCCCCCCCCCC	28.57	25338131
671	Acetylation	WSGTTSSKRMSQSQT CCCCCCCCCCCCCCC	52.46	7611695
674	Phosphorylation	TTSSKRMSQSQTAKG CCCCCCCCCCCCCCC	30.61	25266776
676	Phosphorylation	SSKRMSQSQTAKGVD CCCCCCCCCCCCCCC	23.38	29550500
678	Phosphorylation	KRMSQSQTAKGVDFE CCCCCCCCCCCCCCC	35.27	30635358
686	Phosphorylation	AKGVDFESDEDDDDD CCCCCCCCCCCCCCC	46.42	25521595
698	Phosphorylation	DDDPFMSSSCPRRNR CCCCCCCCCCCCCCC	24.95	29899451
699	Phosphorylation	DDPFMSSSCPRRNRR CCCCCCCCCCCCCCC	22.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRE11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRE11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRE11_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKDC_MOUSE	Prkdc	genetic	19015239
NBN_MOUSE	Nbn	physical	21884979

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.