ACSL4_MOUSE - dbPTM
ACSL4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACSL4_MOUSE
UniProt AC Q9QUJ7
Protein Name Long-chain-fatty-acid--CoA ligase 4
Gene Name Acsl4
Organism Mus musculus (Mouse).
Sequence Length 711
Subcellular Localization Mitochondrion outer membrane
Single-pass type III membrane protein. Peroxisome membrane
Single-pass type III membrane protein. Microsome membrane
Single-pass type III membrane protein. Endoplasmic reticulum membrane
Single-pass type III membrane prote
Protein Description Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates..
Protein Sequence MNLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEASYLITSVELLESKLKAALVDINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGAKPENLSVPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYVQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYCVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationKRIKAKPTSDKPGSP
HHHCCCCCCCCCCCC		49.1821454597
52PhosphorylationRIKAKPTSDKPGSPY
HHCCCCCCCCCCCCC		52.76108430793
54UbiquitinationKAKPTSDKPGSPYRS
CCCCCCCCCCCCCCC		51.5522790023
57PhosphorylationPTSDKPGSPYRSVTH
CCCCCCCCCCCCCCC		27.5624899341
95PhosphorylationAKFGKKDSLGTREIL
HHHCCCCCCCHHHHC		37.2636012715
98PhosphorylationGKKDSLGTREILSEE
CCCCCCCHHHHCCCC		30.35108430799
103PhosphorylationLGTREILSEENEMQP
CCHHHHCCCCCCCCC		48.8321454597
148UbiquitinationGLTALGLKPKNTIAI
CCEECCCCCCCEEEE		52.7422790023
227PhosphorylationNCVKHIIYVDNKTIN
CCCEEEEEECCCEEC		10.9320561301
312UbiquitinationRIPGLGPKDTYIGYL
ECCCCCCCCCEEECC		61.99-
354UbiquitinationTLSDQSSKIKKGSKG
CCCCCCCCCCCCCCC		64.8922790023
356UbiquitinationSDQSSKIKKGSKGDC
CCCCCCCCCCCCCCC		55.61-
360UbiquitinationSKIKKGSKGDCTVLK
CCCCCCCCCCCEECC		68.3922790023
382PhosphorylationPEIMDRIYKNVMSKV
HHHHHHHHHHHHHHH		9.4527357545
394PhosphorylationSKVQEMNYVQKTLFK
HHHHHHHHHHHHHHH		11.7129514104
397UbiquitinationQEMNYVQKTLFKIGY
HHHHHHHHHHHHHCC		36.8322790023
401UbiquitinationYVQKTLFKIGYDYKL
HHHHHHHHHCCCCCH		38.0322790023
415PhosphorylationLEQIKKGYDAPLCNL
HHHHHCCCCCCCHHH		20.1525367039
441PhosphorylationGNVRMMLSGGAPLSP
CCEEEEEECCCCCCC		19.7929472430
447PhosphorylationLSGGAPLSPQTHRFM
EECCCCCCCCCCCCE		17.5729472430
450PhosphorylationGAPLSPQTHRFMNVC
CCCCCCCCCCCEEEE		20.5729472430
500UbiquitinationICCEIKLKDWQEGGY
EEEEEECCCCCCCCE		52.5022790023
536UbiquitinationGYFKNEEKTAEDYCV
EEECCCCCCHHHEEE		47.0222790023
582PhosphorylationVKLQAGEYVSLGKVE
EEECCCCEEEHHHHH		8.40113219
587UbiquitinationGEYVSLGKVEAALKN
CCEEEHHHHHHHHHC		42.0422790023
595S-palmitoylationVEAALKNCPLIDNIC
HHHHHHCCCCCCCEE		2.5128680068
621UbiquitinationSFVVPNQKKLTLLAQ
EEEECCHHHEEEEHH		57.2922790023
635PhosphorylationQQKGVEGSWVDICNN
HHCCCCCCEEECCCC		15.4926745281
651UbiquitinationAMEAEILKEIREAAN
HHHHHHHHHHHHHHH		57.6722790023
661UbiquitinationREAANAMKLERFEIP
HHHHHHCCCEEEECC		44.8022790023
670UbiquitinationERFEIPIKVRLSPEP
EEEECCEEEEECCCC		18.8922790023
674PhosphorylationIPIKVRLSPEPWTPE
CCEEEEECCCCCCCC		19.3622324799
679PhosphorylationRLSPEPWTPETGLVT
EECCCCCCCCCCCCC		23.20145443
682PhosphorylationPEPWTPETGLVTDAF
CCCCCCCCCCCCCHH		36.7023984901
702UbiquitinationELKNHYLKDIERMYG
HHHHHHHHHHHHHHC		49.8722790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACSL4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACSL4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACSL4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ACSL4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACSL4_MOUSE

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Related Literatures of Post-Translational Modification

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