RL13A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL13A_MOUSE
• UniProt AC: P19253
• Protein Name: 60S ribosomal protein L13a
• Gene Name: Rpl13a
• Organism: Mus musculus (Mouse).
• Sequence Length: 203
• Protein Description: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex..
• Protein Sequence: MAEGQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVLDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKMHYRKKKQILRLRKQAEKNVEKKICKFTEVLKTNGLLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEGQVLVL ------CCCCCEEEE	29.62	-
25	Ubiquitination	RLAAIVAKQVLLGRK HHHHHHHHHHHCCCC	30.00	-
25	Acetylation	RLAAIVAKQVLLGRK HHHHHHHHHHHCCCC	30.00	22826441
38	S-palmitoylation	RKVVVVRCEGINISG CCEEEEECEEECCCC	3.67	28526873
38	S-nitrosylation	RKVVVVRCEGINISG CCEEEEECEEECCCC	3.67	21278135
38	S-nitrosocysteine	RKVVVVRCEGINISG CCEEEEECEEECCCC	3.67	-
53	Acetylation	NFYRNKLKYLAFLRK CCHHHHHHHHHHHHH	39.57	22826441
53	Ubiquitination	NFYRNKLKYLAFLRK CCHHHHHHHHHHHHH	39.57	-
54	Phosphorylation	FYRNKLKYLAFLRKR CHHHHHHHHHHHHHH	17.44	29514104
59	Citrullination	LKYLAFLRKRMNTNP HHHHHHHHHHCCCCC	20.34	-
59	Citrullination	LKYLAFLRKRMNTNP HHHHHHHHHHCCCCC	20.34	24463520
71	Phosphorylation	TNPSRGPYHFRAPSR CCCCCCCCCCCCCCH	19.20	29514104
77	Phosphorylation	PYHFRAPSRIFWRTV CCCCCCCCHHHHHHH	36.70	23071094
103	Ubiquitination	QAALERLKVLDGIPP HHHHHHHHHHCCCCC	47.15	-
114	Ubiquitination	GIPPPYDKKKRMVVP CCCCCCCHHHCCHHH	55.11	-
115	Ubiquitination	IPPPYDKKKRMVVPA CCCCCCHHHCCHHHH	42.59	-
125	Acetylation	MVVPAALKVVRLKPT CHHHHHHEEEECCCC	33.68	22826441
125	Ubiquitination	MVVPAALKVVRLKPT CHHHHHHEEEECCCC	33.68	-
134	Acetylation	VRLKPTRKFAYLGRL EECCCCCCHHHHHHH	36.50	22826441
134	Ubiquitination	VRLKPTRKFAYLGRL EECCCCCCHHHHHHH	36.50	-
140	Citrullination	RKFAYLGRLAHEVGW CCHHHHHHHHHHHHH	26.55	24463520
140	Citrullination	RKFAYLGRLAHEVGW CCHHHHHHHHHHHHH	26.55	-
148	Acetylation	LAHEVGWKYQAVTAT HHHHHHHHHHHHHHC	22.89	22826441
149	Phosphorylation	AHEVGWKYQAVTATL HHHHHHHHHHHHHCH	8.66	29514104
155	Phosphorylation	KYQAVTATLEEKRKE HHHHHHHCHHHHHHH	25.90	25338131
159	Ubiquitination	VTATLEEKRKEKAKM HHHCHHHHHHHHHHH	60.44	-
183	Acetylation	RLRKQAEKNVEKKIC HHHHHHHHHHHHHHH	70.12	23201123
188	Acetylation	AEKNVEKKICKFTEV HHHHHHHHHHHHHHH	39.57	23201123
188	Ubiquitination	AEKNVEKKICKFTEV HHHHHHHHHHHHHHH	39.57	-
190	Glutathionylation	KNVEKKICKFTEVLK HHHHHHHHHHHHHHH	3.99	24333276
191	Ubiquitination	NVEKKICKFTEVLKT HHHHHHHHHHHHHHH	59.81	-
191	Acetylation	NVEKKICKFTEVLKT HHHHHHHHHHHHHHH	59.81	23806337
191	Malonylation	NVEKKICKFTEVLKT HHHHHHHHHHHHHHH	59.81	26320211
191	Succinylation	NVEKKICKFTEVLKT HHHHHHHHHHHHHHH	59.81	23806337
197	Ubiquitination	CKFTEVLKTNGLLV- HHHHHHHHHCCCCC-	45.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	S	Phosphorylation	Kinase	DAPK3	O54784	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
77	S	Phosphorylation	Phosphorylation at Ser-77 upon interferon-gamma treatment in macrophages involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.	23071094

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL13A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL13A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.