RMXL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RMXL1_MOUSE
• UniProt AC: Q91VM5
• Protein Name: RNA binding motif protein, X-linked-like-1
• Gene Name: Rbmxl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 388
• Subcellular Localization: Nucleus.
• Protein Description: RNA-binding protein which may be involved in pre-mRNA splicing..
• Protein Sequence: MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEILLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGSGGTRGPPSRGGYMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSTPSGPVRSSSGMGGRTPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYSHSSSRDDYPSRGYGDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVEADRPG -------CCCCCCCC	5.77	-
2	Acetylation	------MVEADRPGK ------CCCCCCCCC	9.26	-
9	Ubiquitination	VEADRPGKLFIGGLN CCCCCCCCEEECCCC	42.79	-
22	Ubiquitination	LNTETNEKALEAVFG CCCCCCHHHHHHHHH	61.41	-
30	Acetylation	ALEAVFGKYGRIVEI HHHHHHHHHHHHHEE	32.82	-
30	Ubiquitination	ALEAVFGKYGRIVEI HHHHHHHHHHHHHEE	32.82	-
55	Phosphorylation	SRGFAFVTFESPADA CCCEEEEEECCCHHH	18.41	23984901
58	Phosphorylation	FAFVTFESPADAKDA EEEEEECCCHHHHHH	22.61	26824392
73	Phosphorylation	ARDMNGKSLDGKAIK HHHHCCCCCCCCEEE	32.84	-
85	Phosphorylation	AIKVEQATKPSFESG EEEEEECCCCCCCCC	43.09	25619855
86	Acetylation	IKVEQATKPSFESGR EEEEECCCCCCCCCC	41.50	23806337
86	Malonylation	IKVEQATKPSFESGR EEEEECCCCCCCCCC	41.50	26320211
86	Ubiquitination	IKVEQATKPSFESGR EEEEECCCCCCCCCC	41.50	27667366
88	Phosphorylation	VEQATKPSFESGRRG EEECCCCCCCCCCCC	43.11	26824392
91	Phosphorylation	ATKPSFESGRRGPPP CCCCCCCCCCCCCCC	35.27	26824392
102	Phosphorylation	GPPPPPRSRGPPRGL CCCCCCCCCCCCCCC	47.57	29514104
107	Methylation	PRSRGPPRGLRGGSG CCCCCCCCCCCCCCC	60.97	58859295
110	Methylation	RGPPRGLRGGSGGTR CCCCCCCCCCCCCCC	50.69	58859283
113	Phosphorylation	PRGLRGGSGGTRGPP CCCCCCCCCCCCCCC	36.55	25266776
116	Phosphorylation	LRGGSGGTRGPPSRG CCCCCCCCCCCCCCC	35.66	30635358
121	Phosphorylation	GGTRGPPSRGGYMDD CCCCCCCCCCCCCCC	46.84	26643407
122	Asymmetric dimethylarginine	GTRGPPSRGGYMDDG CCCCCCCCCCCCCCC	48.61	-
122	Methylation	GTRGPPSRGGYMDDG CCCCCCCCCCCCCCC	48.61	24129315
125	Phosphorylation	GPPSRGGYMDDGGYS CCCCCCCCCCCCCEE	10.53	26643407
131	Phosphorylation	GYMDDGGYSMNFNMS CCCCCCCEECEEECC	15.41	25293948
132	Phosphorylation	YMDDGGYSMNFNMSS CCCCCCEECEEECCC	15.55	25293948
138	Phosphorylation	YSMNFNMSSSRGPLP EECEEECCCCCCCCC	26.68	25293948
139	Phosphorylation	SMNFNMSSSRGPLPV ECEEECCCCCCCCCC	17.18	25293948
140	Phosphorylation	MNFNMSSSRGPLPVK CEEECCCCCCCCCCC	33.67	25293948
141	Methylation	NFNMSSSRGPLPVKR EEECCCCCCCCCCCC	53.34	24129315
147	Acetylation	SRGPLPVKRGPPPRS CCCCCCCCCCCCCCC	50.09	8277147
147	Malonylation	SRGPLPVKRGPPPRS CCCCCCCCCCCCCCC	50.09	26320211
147	Ubiquitination	SRGPLPVKRGPPPRS CCCCCCCCCCCCCCC	50.09	27667366
154	Phosphorylation	KRGPPPRSGGPPPKR CCCCCCCCCCCCCCC	54.60	22817900
161	Methylation	SGGPPPKRSTPSGPV CCCCCCCCCCCCCCC	52.08	58859277
162	Phosphorylation	GGPPPKRSTPSGPVR CCCCCCCCCCCCCCC	51.28	25521595
163	Phosphorylation	GPPPKRSTPSGPVRS CCCCCCCCCCCCCCC	26.05	27087446
165	Phosphorylation	PPKRSTPSGPVRSSS CCCCCCCCCCCCCCC	56.68	22942356
169	Methylation	STPSGPVRSSSGMGG CCCCCCCCCCCCCCC	33.67	18966979
170	Phosphorylation	TPSGPVRSSSGMGGR CCCCCCCCCCCCCCC	29.14	27717184
171	Phosphorylation	PSGPVRSSSGMGGRT CCCCCCCCCCCCCCC	21.98	-
172	Phosphorylation	SGPVRSSSGMGGRTP CCCCCCCCCCCCCCC	33.76	27717184
178	Phosphorylation	SSGMGGRTPVSRGRD CCCCCCCCCCCCCCC	31.17	25266776
181	Phosphorylation	MGGRTPVSRGRDSYG CCCCCCCCCCCCCCC	30.16	27600695
186	Phosphorylation	PVSRGRDSYGGPPRR CCCCCCCCCCCCCCC	25.07	29472430
187	Phosphorylation	VSRGRDSYGGPPRRE CCCCCCCCCCCCCCC	30.32	28066266
198	Phosphorylation	PRREPLPSRRDVYLS CCCCCCCCCCCCEEC	47.86	29176673
203	Phosphorylation	LPSRRDVYLSPRDDG CCCCCCCEECCCCCC	13.02	24925903
205	Phosphorylation	SRRDVYLSPRDDGYS CCCCCEECCCCCCCC	10.53	15748150
205	Phosphorylation	SRRDVYLSPRDDGYS CCCCCEECCCCCCCC	10.53	24925903
211	Phosphorylation	LSPRDDGYSTKDSYS ECCCCCCCCCCCCCC	21.84	28833060
212	Phosphorylation	SPRDDGYSTKDSYSS CCCCCCCCCCCCCCC	34.21	24925903
213	Phosphorylation	PRDDGYSTKDSYSSR CCCCCCCCCCCCCCC	30.32	28833060
214	Ubiquitination	RDDGYSTKDSYSSRD CCCCCCCCCCCCCCC	38.44	-
216	Phosphorylation	DGYSTKDSYSSRDYP CCCCCCCCCCCCCCC	28.59	26643407
217	Phosphorylation	GYSTKDSYSSRDYPS CCCCCCCCCCCCCCC	22.31	26643407
218	Phosphorylation	YSTKDSYSSRDYPSS CCCCCCCCCCCCCCC	23.89	26643407
219	Phosphorylation	STKDSYSSRDYPSSR CCCCCCCCCCCCCCC	22.42	26643407
222	Phosphorylation	DSYSSRDYPSSRDTR CCCCCCCCCCCCCCC	12.14	26643407
225	Phosphorylation	SSRDYPSSRDTRDYA CCCCCCCCCCCCCCC	29.66	29899451
243	Phosphorylation	RDYTYRDYSHSSSRD CCCCCCCCCCCCCCC	10.17	25619855
244	Phosphorylation	DYTYRDYSHSSSRDD CCCCCCCCCCCCCCC	22.60	27742792
246	Phosphorylation	TYRDYSHSSSRDDYP CCCCCCCCCCCCCCC	24.86	26824392
247	Phosphorylation	YRDYSHSSSRDDYPS CCCCCCCCCCCCCCC	24.78	27742792
248	Phosphorylation	RDYSHSSSRDDYPSR CCCCCCCCCCCCCCC	42.62	27742792
252	Phosphorylation	HSSSRDDYPSRGYGD CCCCCCCCCCCCCCC	13.85	25619855
254	Phosphorylation	SSRDDYPSRGYGDRD CCCCCCCCCCCCCCC	31.91	25619855
269	Phosphorylation	GYGRDRDYSDHPSGG CCCCCCCCCCCCCCC	19.52	25367039
270	Phosphorylation	YGRDRDYSDHPSGGS CCCCCCCCCCCCCCC	33.46	23684622
274	Phosphorylation	RDYSDHPSGGSYRDS CCCCCCCCCCCCCCC	52.98	26643407
277	Phosphorylation	SDHPSGGSYRDSYES CCCCCCCCCCCCHHH	22.11	26643407
278	Phosphorylation	DHPSGGSYRDSYESY CCCCCCCCCCCHHHC	23.01	26643407
281	Phosphorylation	SGGSYRDSYESYGNS CCCCCCCCHHHCCCC	23.08	26643407
282	Phosphorylation	GGSYRDSYESYGNSR CCCCCCCHHHCCCCC	17.12	25159016
284	Phosphorylation	SYRDSYESYGNSRSA CCCCCHHHCCCCCCC	30.06	25159016
285	Phosphorylation	YRDSYESYGNSRSAP CCCCHHHCCCCCCCC	14.37	26643407
288	Phosphorylation	SYESYGNSRSAPPTR CHHHCCCCCCCCCCC	24.21	27841257
290	Phosphorylation	ESYGNSRSAPPTRGP HHCCCCCCCCCCCCC	44.97	26643407
294	Phosphorylation	NSRSAPPTRGPPPSY CCCCCCCCCCCCCCC	47.39	29514104
295	Methylation	SRSAPPTRGPPPSYG CCCCCCCCCCCCCCC	62.49	-
300	Phosphorylation	PTRGPPPSYGGSSRY CCCCCCCCCCCCCCC	42.03	27149854
304	Phosphorylation	PPPSYGGSSRYDDYS CCCCCCCCCCCCCCC	13.79	27149854
307	Phosphorylation	SYGGSSRYDDYSSSR CCCCCCCCCCCCCCC	18.34	25777480
310	Phosphorylation	GSSRYDDYSSSRDGY CCCCCCCCCCCCCCC	13.93	26643407
311	Phosphorylation	SSRYDDYSSSRDGYG CCCCCCCCCCCCCCC	28.91	26643407
312	Phosphorylation	SRYDDYSSSRDGYGG CCCCCCCCCCCCCCC	24.14	26525534
313	Phosphorylation	RYDDYSSSRDGYGGS CCCCCCCCCCCCCCC	28.57	25521595
317	Phosphorylation	YSSSRDGYGGSRDSY CCCCCCCCCCCCCCC	23.70	25159016
320	Phosphorylation	SRDGYGGSRDSYSSS CCCCCCCCCCCCCCC	28.66	25159016
323	Phosphorylation	GYGGSRDSYSSSRSD CCCCCCCCCCCCHHH	26.29	23527152
324	Phosphorylation	YGGSRDSYSSSRSDL CCCCCCCCCCCHHHH	19.50	25619855
325	Phosphorylation	GGSRDSYSSSRSDLY CCCCCCCCCCHHHHH	26.28	23527152
326	Phosphorylation	GSRDSYSSSRSDLYS CCCCCCCCCHHHHHH	22.87	25168779
327	Phosphorylation	SRDSYSSSRSDLYSS CCCCCCCCHHHHHHC	29.84	25521595
329	Phosphorylation	DSYSSSRSDLYSSGR CCCCCCHHHHHHCCC	33.64	21082442
332	Phosphorylation	SSSRSDLYSSGRDRV CCCHHHHHHCCCCCC	13.04	25619855
333	Phosphorylation	SSRSDLYSSGRDRVG CCHHHHHHCCCCCCC	33.35	25619855
334	Phosphorylation	SRSDLYSSGRDRVGR CHHHHHHCCCCCCCC	25.04	25619855
349	Phosphorylation	QERGLPPSMERGYPP CCCCCCCHHHCCCCC	31.19	27087446
354	Phosphorylation	PPSMERGYPPPRDSY CCHHHCCCCCCCCCC	20.84	23984901
358	Methylation	ERGYPPPRDSYSSSS HCCCCCCCCCCCCCC	51.81	16188017

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RMXL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RMXL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RMXL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RMXL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.