UBE3C_MOUSE - dbPTM
UBE3C_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBE3C_MOUSE
UniProt AC Q80U95
Protein Name Ubiquitin-protein ligase E3C
Gene Name Ube3c
Organism Mus musculus (Mouse).
Sequence Length 1083
Subcellular Localization Nucleus .
Protein Description E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo..
Protein Sequence MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAVIIQSFIRGYRDRKQQYFIQRSAFDQCTDSAQPGGTFCLADGPNLTLLVRQLLFFYKQSEDSKRLIWLYQNLIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCSDDSLNVALPMRMLEVFTSENTYLPVLQDSSYVVSVIEQILHYMVHSGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLENVLKPLHFTYSSCPEASRHQVFSAFTEEFLGAPFTDQIFHFVIPAFADAQTVFPYEPFLNALLLLESQSSKRCSGVPWLFYFVLTVGENYLGALSEDGLLVYLRVLQTFLSQLPASPTGTGCPDSTSDSEDDNEETDQPNSPEDGRVSAPYITEECLRKLDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVTAFQSIGVTTNSEMQQCIQMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLESLPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationKVSLGGASRKEEKAS
CCCCCCCCCHHHHHH		47.3522324799
63UbiquitinationIRGYRDRKQQYFIQR
HHCCHHHHHHHEEEH		46.1522790023
355PhosphorylationFLSQLPASPTGTGCP
HHHCCCCCCCCCCCC		22.5125293948
357PhosphorylationSQLPASPTGTGCPDS
HCCCCCCCCCCCCCC		44.9025293948
359PhosphorylationLPASPTGTGCPDSTS
CCCCCCCCCCCCCCC		37.7825293948
364PhosphorylationTGTGCPDSTSDSEDD
CCCCCCCCCCCCCCC		18.2325293948
365PhosphorylationGTGCPDSTSDSEDDN
CCCCCCCCCCCCCCC		43.8925293948
366PhosphorylationTGCPDSTSDSEDDNE
CCCCCCCCCCCCCCC		42.9925293948
368PhosphorylationCPDSTSDSEDDNEET
CCCCCCCCCCCCCCC		42.5725293948
375PhosphorylationSEDDNEETDQPNSPE
CCCCCCCCCCCCCCC		33.4825293948
380PhosphorylationEETDQPNSPEDGRVS
CCCCCCCCCCCCCCC		36.0325293948
447PhosphorylationVPKVRLLYSLAFNAR
HCHHHHHHHHHHHHH		13.26-
464PhosphorylationRHLWFLISSMTTQMI
HHHHHHHHHHHHHHH		19.0624759943
465PhosphorylationHLWFLISSMTTQMIT
HHHHHHHHHHHHHHC		17.1029119230
467PhosphorylationWFLISSMTTQMITGS
HHHHHHHHHHHHCCC		18.8029119230
468PhosphorylationFLISSMTTQMITGSM
HHHHHHHHHHHCCCH		13.9029119230
472PhosphorylationSMTTQMITGSMVPLL
HHHHHHHCCCHHHHH		20.1924759943
474PhosphorylationTTQMITGSMVPLLQL
HHHHHCCCHHHHHHH		14.1429119230
483PhosphorylationVPLLQLISRGSPMSF
HHHHHHHHCCCCCCC		38.9029119230
489PhosphorylationISRGSPMSFEDSSRI
HHCCCCCCCCCHHCH		28.9424759943
565UbiquitinationKLAYPETKPEVREEY
HHHCCCCCHHHHHHH		37.2027667366
638UbiquitinationQEDIKADKVTQLYVP
HHCCCCCCEEEEEEC		52.6322790023
845PhosphorylationPFAGFFLSKLLGTSA
CHHHHHHHHHHCCCC		18.99-
907UbiquitinationVELKFGGKDIPVTGA
EEEEECCEECCCCCC		53.5227667366
972PhosphorylationSGAQVPVSLEDLKSF
CCCCCCCCHHHHHHH		21.7022324799
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBE3C_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBE3C_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBE3C_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UBE3C_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBE3C_MOUSE

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Related Literatures of Post-Translational Modification

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