WASC5_MOUSE - dbPTM
WASC5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WASC5_MOUSE
UniProt AC Q8C2E7
Protein Name WASH complex subunit 5 {ECO:0000312|MGI:MGI:2146110}
Gene Name Washc5 {ECO:0000312|MGI:MGI:2146110}
Organism Mus musculus (Mouse).
Sequence Length 1159
Subcellular Localization Cytoplasm, cytosol . Endoplasmic reticulum . Early endosome . Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord.
Protein Description Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. [PubMed: 24998208]
Protein Sequence MLDFLAENNLCGQAILRIVSCGNAIIAEVLRLSEFIPAVFLLKDRADQQRYGDIIFDFSYFKGPEFWESKLEAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLSEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGAKRPPNYPESYFQRVPINETFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLADAWEPYKAAKTALNNTLDLANVKEQASRYASVSDRVRAQVQQFLKEGYLREEVLLDNIPRLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILADSRYNPKILFQLLLDTAQFEFILKEMFKQMLSEKQSKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITVQIIGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIMEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFAPVDESITFIGRLCREILRITDPKMTCYIDQLNTWYDVKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILKERTVQETLKMLMSAVNPLKSIVANSSKVYLSAITKTQKIWSAYLEAIMKVGQMQILRQQIANELNSSCRFDSRHLAAALDNLNKALLADIEAHYRDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPADPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSTMEQCTSQKMPEMPADAVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
202UbiquitinationYSSQPGAKRPPNYPE
CCCCCCCCCCCCCCH
22790023
324UbiquitinationTLDLANVKEQASRYA
HHHHHHHHHHHHHHC
22790023
349PhosphorylationQQFLKEGYLREEVLL
HHHHHHCCCCHHHHH
29514104
451PhosphorylationKEGSERMTELADVFS
HHHHHHHHHHHHHHC
21454597
461UbiquitinationADVFSGVKPLTRVEK
HHHHCCCCCCCCCCC
22790023
664PhosphorylationDKDKLRDYAQLGPRY
CHHHHHHHHHHCCHH
29514104
910AcetylationRTVQETLKMLMSAVN
CHHHHHHHHHHHHHC
23341599
914PhosphorylationETLKMLMSAVNPLKS
HHHHHHHHHHCHHHH
25338131
920UbiquitinationMSAVNPLKSIVANSS
HHHHCHHHHHHHCCC
22790023
921PhosphorylationSAVNPLKSIVANSSK
HHHCHHHHHHHCCCC
22871156
926PhosphorylationLKSIVANSSKVYLSA
HHHHHHCCCCCHHHH
22871156
930PhosphorylationVANSSKVYLSAITKT
HHCCCCCHHHHHHHH
22871156
935PhosphorylationKVYLSAITKTQKIWS
CCHHHHHHHHHHHHH
22871156
937PhosphorylationYLSAITKTQKIWSAY
HHHHHHHHHHHHHHH
22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WASC5_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WASC5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WASC5_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of WASC5_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WASC5_MOUSE

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Related Literatures of Post-Translational Modification

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