UniProt ID | WASC5_MOUSE | |
---|---|---|
UniProt AC | Q8C2E7 | |
Protein Name | WASH complex subunit 5 {ECO:0000312|MGI:MGI:2146110} | |
Gene Name | Washc5 {ECO:0000312|MGI:MGI:2146110} | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1159 | |
Subcellular Localization | Cytoplasm, cytosol . Endoplasmic reticulum . Early endosome . Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. | |
Protein Description | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. [PubMed: 24998208] | |
Protein Sequence | MLDFLAENNLCGQAILRIVSCGNAIIAEVLRLSEFIPAVFLLKDRADQQRYGDIIFDFSYFKGPEFWESKLEAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLSEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGAKRPPNYPESYFQRVPINETFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLADAWEPYKAAKTALNNTLDLANVKEQASRYASVSDRVRAQVQQFLKEGYLREEVLLDNIPRLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILADSRYNPKILFQLLLDTAQFEFILKEMFKQMLSEKQSKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITVQIIGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIMEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFAPVDESITFIGRLCREILRITDPKMTCYIDQLNTWYDVKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILKERTVQETLKMLMSAVNPLKSIVANSSKVYLSAITKTQKIWSAYLEAIMKVGQMQILRQQIANELNSSCRFDSRHLAAALDNLNKALLADIEAHYRDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPADPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSTMEQCTSQKMPEMPADAVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
202 | Ubiquitination | YSSQPGAKRPPNYPE CCCCCCCCCCCCCCH | 22790023 | ||
324 | Ubiquitination | TLDLANVKEQASRYA HHHHHHHHHHHHHHC | 22790023 | ||
349 | Phosphorylation | QQFLKEGYLREEVLL HHHHHHCCCCHHHHH | 29514104 | ||
451 | Phosphorylation | KEGSERMTELADVFS HHHHHHHHHHHHHHC | 21454597 | ||
461 | Ubiquitination | ADVFSGVKPLTRVEK HHHHCCCCCCCCCCC | 22790023 | ||
664 | Phosphorylation | DKDKLRDYAQLGPRY CHHHHHHHHHHCCHH | 29514104 | ||
910 | Acetylation | RTVQETLKMLMSAVN CHHHHHHHHHHHHHC | 23341599 | ||
914 | Phosphorylation | ETLKMLMSAVNPLKS HHHHHHHHHHCHHHH | 25338131 | ||
920 | Ubiquitination | MSAVNPLKSIVANSS HHHHCHHHHHHHCCC | 22790023 | ||
921 | Phosphorylation | SAVNPLKSIVANSSK HHHCHHHHHHHCCCC | 22871156 | ||
926 | Phosphorylation | LKSIVANSSKVYLSA HHHHHHCCCCCHHHH | 22871156 | ||
930 | Phosphorylation | VANSSKVYLSAITKT HHCCCCCHHHHHHHH | 22871156 | ||
935 | Phosphorylation | KVYLSAITKTQKIWS CCHHHHHHHHHHHHH | 22871156 | ||
937 | Phosphorylation | YLSAITKTQKIWSAY HHHHHHHHHHHHHHH | 22871156 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
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Oops, there are no upstream regulatory protein records of WASC5_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WASC5_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WASC5_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of WASC5_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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