LIN41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIN41_MOUSE
• UniProt AC: Q1PSW8
• Protein Name: E3 ubiquitin-protein ligase TRIM71
• Gene Name: Trim71
• Organism: Mus musculus (Mouse).
• Sequence Length: 855
• Subcellular Localization: Cytoplasm, P-body .
• Protein Description: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. [PubMed: 19898466 Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression]
• Protein Sequence: MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATAEEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLMRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPPDQALYLALKSIGFVSSGAFAPLTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDGEGKLCRPWGVSVDKEGFIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIIVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVVDFGNNRILIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASFPETDF ------CCCCCCCHH	21.63	-
87	Ubiquitination	AGPAEALKLRCPVCD CCHHHHHHHCCCCCC	40.72	-
174	Phosphorylation	PPPGPAASPGSLLMR CCCCCCCCCCCCCCC	31.72	22006019
449	Phosphorylation	EDDRIMFTPPDQALY CCCCEEECCHHHHHH	19.28	27357545
456	Phosphorylation	TPPDQALYLALKSIG CCHHHHHHHHHHHHC	7.92	27357545

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIN41_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIN41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIN41_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGO2_MOUSE	Ago2	physical	19898466
TNR6A_MOUSE	Tnrc6a	physical	19898466
DCP1A_MOUSE	Dcp1a	physical	19898466
EDC4_MOUSE	Edc4	physical	19898466
MOV10_MOUSE	Mov10	physical	19898466
LIN41_MOUSE	Trim71	physical	19898466
SHCBP_MOUSE	Shcbp1	physical	22508726
UB2D1_MOUSE	Ube2d1	physical	19898466

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.