DCP1A_MOUSE - dbPTM
DCP1A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCP1A_MOUSE
UniProt AC Q91YD3
Protein Name mRNA-decapping enzyme 1A
Gene Name Dcp1a
Organism Mus musculus (Mouse).
Sequence Length 602
Subcellular Localization Cytoplasm, P-body . Nucleus . Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity). Colocalizes with NANOS3 in the processing bodies (PubM
Protein Description Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity)..
Protein Sequence MALSCSTVRPRRRGSALRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDQRPIDILEMLSRAKDEYERNQMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPTAMGLESEDTDKLLGDASQKEPSSFLPFPFEQSGGAPQSENLGIHSAAHHTVQPEVSTPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTMIQAVKTTPRQKSPLLNQPVPELSHSSLVASQSPFRAPVSLANPAGTALPSVDLLQKLRLTPQHDQIQAQPLGKGTMAPSFSSAAGQLATPESFIEPSSKTAAARAAVSASLSNMVLAPTLQSMQQNQDPEVFSQPKVLPSAIPIAGSPLVPATTTAVSSVLLSPSVFQQTVPRAADLERKASSPSPLTVGTAESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHAVYLQVLTKNKDNHNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MALSCSTVRPR
----CCCCCCCCCCC		9.1129895711
7Phosphorylation-MALSCSTVRPRRRG
-CCCCCCCCCCCCCC		25.51-
15PhosphorylationVRPRRRGSALRSKME
CCCCCCCHHHHHHHH		23.48-
19PhosphorylationRRGSALRSKMELLSR
CCCHHHHHHHHHHHH		36.8926026062
25PhosphorylationRSKMELLSRAEQEMS
HHHHHHHHHHHHHHH		41.9126026062
32PhosphorylationSRAEQEMSLAALKQH
HHHHHHHHHHHHHHC		17.6929899451
44PhosphorylationKQHDPYITSIADLTG
HHCCCCHHHHHHHCC		14.29-
45PhosphorylationQHDPYITSIADLTGQ
HCCCCHHHHHHHCCC		13.25-
56PhosphorylationLTGQVALYTFCPKAN
HCCCEEEEEECCCCC		6.50-
80PhosphorylationTLFVYRRSASPYHGF
EEEEEEECCCCCCCE		24.8928833060
82PhosphorylationFVYRRSASPYHGFTI
EEEEECCCCCCCEEE		27.5123684622
84PhosphorylationYRRSASPYHGFTIVN
EEECCCCCCCEEEEE		16.4528833060
88PhosphorylationASPYHGFTIVNRLNM
CCCCCCEEEEECCCC		28.7128833060
153PhosphorylationVEEETRRSQQAARDK
HHHHHHHHHHHHHHC		24.29-
162PhosphorylationQAARDKQSPSQANGC
HHHHHCCCHHHCCCC		32.0521082442
164PhosphorylationARDKQSPSQANGCSD
HHHCCCHHHCCCCCC		47.3621082442
170PhosphorylationPSQANGCSDQRPIDI
HHHCCCCCCCCCHHH		37.8725159016
182PhosphorylationIDILEMLSRAKDEYE
HHHHHHHHHCHHHHH		28.9625367039
196PhosphorylationERNQMGGSNISSPGL
HHHCCCCCCCCCCCC		25.8421743459
199PhosphorylationQMGGSNISSPGLQPS
CCCCCCCCCCCCCCC		34.4325521595
200PhosphorylationMGGSNISSPGLQPST
CCCCCCCCCCCCCCC		21.1322942356
206PhosphorylationSSPGLQPSTQLSNLG
CCCCCCCCCCHHCCC		18.8021743459
207PhosphorylationSPGLQPSTQLSNLGS
CCCCCCCCCHHCCCC		39.9721743459
210PhosphorylationLQPSTQLSNLGSTET
CCCCCCHHCCCCCCC		21.8621743459
214PhosphorylationTQLSNLGSTETLEET
CCHHCCCCCCCCCCC		26.6621743459
215PhosphorylationQLSNLGSTETLEETP
CHHCCCCCCCCCCCC		31.0621743459
217PhosphorylationSNLGSTETLEETPSG
HCCCCCCCCCCCCCC		39.2921743459
221PhosphorylationSTETLEETPSGSQDK
CCCCCCCCCCCCCCC		17.2425293948
225PhosphorylationLEETPSGSQDKSAPS
CCCCCCCCCCCCCCC		39.2725293948
245PhosphorylationTVEELFGTSLPKEQP
EHHHHHCCCCCCCCC		21.5426745281
246PhosphorylationVEELFGTSLPKEQPT
HHHHHCCCCCCCCCC		42.9526745281
253PhosphorylationSLPKEQPTAMGLESE
CCCCCCCCCCCCCCC		29.0430635358
259PhosphorylationPTAMGLESEDTDKLL
CCCCCCCCCCHHHHC		45.9030635358
262PhosphorylationMGLESEDTDKLLGDA
CCCCCCCHHHHCCCC		30.8624719451
329PhosphorylationSGDKHPPSYTLPLSP
CCCCCCCCCCCCCCC		34.8925159016
330PhosphorylationGDKHPPSYTLPLSPV
CCCCCCCCCCCCCCC		20.3325159016
331PhosphorylationDKHPPSYTLPLSPVL
CCCCCCCCCCCCCCC		26.6625159016
335PhosphorylationPSYTLPLSPVLSPTL
CCCCCCCCCCCCCCC		15.8327087446
339PhosphorylationLPLSPVLSPTLPAEA
CCCCCCCCCCCCCCC		18.9727087446
341PhosphorylationLSPVLSPTLPAEAPT
CCCCCCCCCCCCCCC		41.8325159016
348PhosphorylationTLPAEAPTTQVPHLP
CCCCCCCCCCCCCCC		36.5925159016
349PhosphorylationLPAEAPTTQVPHLPR
CCCCCCCCCCCCCCC		26.8925159016
367PhosphorylationMIQAVKTTPRQKSPL
CHHEECCCCCCCCCC		15.6829514104
372PhosphorylationKTTPRQKSPLLNQPV
CCCCCCCCCCCCCCC		16.6726824392
383PhosphorylationNQPVPELSHSSLVAS
CCCCCCCCHHHHHCC		21.4725159016
385PhosphorylationPVPELSHSSLVASQS
CCCCCCHHHHHCCCC		23.2225159016
386PhosphorylationVPELSHSSLVASQSP
CCCCCHHHHHCCCCC		22.8025159016
390PhosphorylationSHSSLVASQSPFRAP
CHHHHHCCCCCCCCC		24.5825159016
392PhosphorylationSSLVASQSPFRAPVS
HHHHCCCCCCCCCCC		24.4225159016
395MethylationVASQSPFRAPVSLAN
HCCCCCCCCCCCCCC		41.17-
395Asymmetric dimethylarginineVASQSPFRAPVSLAN
HCCCCCCCCCCCCCC		41.17-
399O-linked_GlycosylationSPFRAPVSLANPAGT
CCCCCCCCCCCCCCC		22.2430059200
420PhosphorylationLLQKLRLTPQHDQIQ
HHHHHCCCCCCCCCC		17.9226824392
439PhosphorylationGKGTMAPSFSSAAGQ
CCCCCCCCHHHCCCC		28.3728059163
441PhosphorylationGTMAPSFSSAAGQLA
CCCCCCHHHCCCCCC		24.33-
500PhosphorylationSQPKVLPSAIPIAGS
CCCCCCCCCCCCCCC		34.3725293948
507PhosphorylationSAIPIAGSPLVPATT
CCCCCCCCCCCCCCH		13.1625293948
513PhosphorylationGSPLVPATTTAVSSV
CCCCCCCCHHHHHHH		20.7125293948
514PhosphorylationSPLVPATTTAVSSVL
CCCCCCCHHHHHHHH		18.1825293948
515PhosphorylationPLVPATTTAVSSVLL
CCCCCCHHHHHHHHC		22.2525293948
518PhosphorylationPATTTAVSSVLLSPS
CCCHHHHHHHHCCHH		16.5625293948
519PhosphorylationATTTAVSSVLLSPSV
CCHHHHHHHHCCHHH		15.3625293948
523PhosphorylationAVSSVLLSPSVFQQT
HHHHHHCCHHHHCCC		15.8025293948
530PhosphorylationSPSVFQQTVPRAADL
CHHHHCCCCCCHHHH		22.9925777480
542PhosphorylationADLERKASSPSPLTV
HHHHHHCCCCCCCCC		45.9025521595
543PhosphorylationDLERKASSPSPLTVG
HHHHHCCCCCCCCCC		33.9727087446
545PhosphorylationERKASSPSPLTVGTA
HHHCCCCCCCCCCCC		34.1927087446
548PhosphorylationASSPSPLTVGTAESQ
CCCCCCCCCCCCCCC		21.9225521595
551PhosphorylationPSPLTVGTAESQRKP
CCCCCCCCCCCCCCC		23.9425619855
554PhosphorylationLTVGTAESQRKPSII
CCCCCCCCCCCCEEE		32.5925619855
559PhosphorylationAESQRKPSIILSKSQ
CCCCCCCEEEEEHHH		25.8728833060
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
335SPhosphorylationKinaseMAPK1P28482
GPS
335SPhosphorylationKinaseERK2P63085
PSP
339SPhosphorylationKinaseMAPK1P28482
GPS
339SPhosphorylationKinaseERK2P63085
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCP1A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCP1A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DCP1A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCP1A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543 AND SER-545, ANDMASS SPECTROMETRY.

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