TNR6A_MOUSE - dbPTM
TNR6A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNR6A_MOUSE
UniProt AC Q3UHK8
Protein Name Trinucleotide repeat-containing gene 6A protein
Gene Name Tnrc6a
Organism Mus musculus (Mouse).
Sequence Length 1896
Subcellular Localization Cytoplasm, P-body . Mammalian P-bodies are also known as GW bodies (GWBs).
Protein Description Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). [PubMed: 22187428 Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins]
Protein Sequence MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSDNGTSTATSTNNNAKRATASNQQPPPPQQQQPQQEQQQQQPQALPRYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSAVTNQQPQNNGEVQNSKSQSDINHNTSGSHYENCQRGPVSSTSDCSTSCKNAVNDLLEKEAWPSAPGSDPELAPECIDADSASNSESERNITVMASGNTGGEKDGLRNSTGLGSQSKFVVGSSSNNVGHGSSTGPWGFPHGALISTCQVSVDAPESKPESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQNINSKVSGSSTHGTWGSLQETCEPEVSGTQKVSFSGQPQNITTETTGPNNTTNFMTSSLPNSGSVQNNELPTSNPGAWRVSTMNHPQIQAPSVMNGTSLSHLSNGESKTGGSYGTTWGAYGSNYSGDKCAGPNGQANGDTVNATLMQPGINGPMGTNFQVNTNKGGGVWEPGTVNSQSSPWGSGNGANSGGSRRGWGSPAQNTGTGLSSVEWNKLPSNQHSNDSANGNGKKLTNGWKSTEEDDQGSATSQTNEQNSVWAKAGGTVESDGSAESTGRLEEKVTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACTDKTSPNSNDTSSVSGWGDPKPTLRWGDSKGSNCQGGWEDDSAATGMIKSNQWGGCKEDKSTWNDSQKSKQGWGDGQKSSQGWSISAGDNWGESSRSNHWGEANKKSSSGGSDSDRSISGWNELGKTSSFTWGNNINPNNSSGWDESSKPNSSQGWGDPPKCNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATSKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNIPEASGRSDQQAQMHRLLPAASAVSSKETSSGSGWGEPWAEPSTPATTVDNGTSAWGKPIDSGPSWGEPITAASNASTWGSSSVGPQSLSKSGPKSMQDGWCGDDMPLPGSRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEDAWINPFVKQFSNISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKNGNPNMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSAPSANRQQQDQQGRPLSVQQQMMQQSRQLDPSLLVKQQTPPSQQPLHQPAMKSFLDNVMPHTTPELQKGPSPVNAFSNFPIGLNSNLNVNMDMNSIKEPQSRLRKWTTVDSMSVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTPGSVINSLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRVGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSHSFSSRTDVNHWNGAGLSGANCGDLHGTSLWGTPHYSTSLWGPPSSDPRGISSPSPINAFLSVDHLGGGGESM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationKDVERNLSRDLVQEE
HHHHHHHHHHHHHHH		27.5729514104
193PhosphorylationHNTSGSHYENCQRGP
CCCCCCCCCCCCCCC		15.5525367039
271PhosphorylationEKDGLRNSTGLGSQS
CCCCCCCCCCCCCCC		19.8825338131
588PhosphorylationGSRRGWGSPAQNTGT
CCCCCCCCCCCCCCC		21.0126643407
628PhosphorylationKLTNGWKSTEEDDQG
CCCCCCCCCCCCCCC		34.2425777480
629PhosphorylationLTNGWKSTEEDDQGS
CCCCCCCCCCCCCCC		39.4025777480
636PhosphorylationTEEDDQGSATSQTNE
CCCCCCCCCCCCCCC		23.8125777480
638PhosphorylationEDDQGSATSQTNEQN
CCCCCCCCCCCCCCC		24.0625777480
639PhosphorylationDDQGSATSQTNEQNS
CCCCCCCCCCCCCCC		34.4225777480
641PhosphorylationQGSATSQTNEQNSVW
CCCCCCCCCCCCCEE		40.2525777480
646PhosphorylationSQTNEQNSVWAKAGG
CCCCCCCCEEEEECC		20.8025777480
657PhosphorylationKAGGTVESDGSAEST
EECCEECCCCCHHHC		42.8229514104
660PhosphorylationGTVESDGSAESTGRL
CEECCCCCHHHCCCC		33.5829514104
663PhosphorylationESDGSAESTGRLEEK
CCCCCHHHCCCCEEE		35.5629514104
664PhosphorylationSDGSAESTGRLEEKV
CCCCHHHCCCCEEEC		20.16-
717PhosphorylationQTPIKQNTAWDTETS
CCCCCCCCCCCCCCC		26.9925777480
721PhosphorylationKQNTAWDTETSPRGE
CCCCCCCCCCCCCCC		30.3826643407
723PhosphorylationNTAWDTETSPRGERK
CCCCCCCCCCCCCEE		46.2326643407
724PhosphorylationTAWDTETSPRGERKT
CCCCCCCCCCCCEEC		13.3325266776
783PhosphorylationRWGDSKGSNCQGGWE
ECCCCCCCCCCCCCC		37.8621659604
858PhosphorylationWGEANKKSSSGGSDS
CCCCCCCCCCCCCCC		31.2028609623
859PhosphorylationGEANKKSSSGGSDSD
CCCCCCCCCCCCCCC		41.7128609623
860PhosphorylationEANKKSSSGGSDSDR
CCCCCCCCCCCCCCC		55.0228609623
863PhosphorylationKKSSSGGSDSDRSIS
CCCCCCCCCCCCCCC		37.1528609623
865PhosphorylationSSSGGSDSDRSISGW
CCCCCCCCCCCCCCC		36.3028609623
922PhosphorylationQSLGWGDSSKPVSSP
CCCCCCCCCCCCCCC		36.0026745281
923PhosphorylationSLGWGDSSKPVSSPD
CCCCCCCCCCCCCCC		45.8026745281
927PhosphorylationGDSSKPVSSPDWNKQ
CCCCCCCCCCCHHHC		44.6825521595
928PhosphorylationDSSKPVSSPDWNKQQ
CCCCCCCCCCHHHCC		27.4123375375
970PhosphorylationPAKEEEPTGWEEPSP
CCCCCCCCCCCCCCH		59.2021149613
976PhosphorylationPTGWEEPSPESIRRK
CCCCCCCCHHHHHHH		44.5825521595
979PhosphorylationWEEPSPESIRRKMEI
CCCCCHHHHHHHCCC		25.4428066266
1194PhosphorylationNPFVKQFSNISFSRD
CHHHHHHCCCCCCCC		30.6626643407
1197PhosphorylationVKQFSNISFSRDSPE
HHHHCCCCCCCCCHH		22.7826643407
1199PhosphorylationQFSNISFSRDSPEEN
HHCCCCCCCCCHHHH		28.5226643407
1202PhosphorylationNISFSRDSPEENVQS
CCCCCCCCHHHHHHC		32.8525521595
1209PhosphorylationSPEENVQSNKMDLSG
CHHHHHHCCCCCCCC		33.8526643407
1254PhosphorylationRPQISKESSMERNPY
CCCCCCCCCCCCCCC		38.4326643407
1255PhosphorylationPQISKESSMERNPYF
CCCCCCCCCCCCCCC		26.2526643407
1292PhosphorylationQPPAQPLSSSQPNLR
CCCCCCCCCCCCCHH		34.3323140645
1293PhosphorylationPPAQPLSSSQPNLRA
CCCCCCCCCCCCHHC		40.4523140645
1294PhosphorylationPAQPLSSSQPNLRAQ
CCCCCCCCCCCHHCC		46.4023527152
1406PhosphorylationSLLVKQQTPPSQQPL
HHHHCCCCCCCCCCC		34.3725338131
1438PhosphorylationPELQKGPSPVNAFSN
HHHHCCCCCCCCCCC		50.5826643407
1504PhosphorylationSGFRLEESPFVPYDF
CCEECCCCCCCCCCC		17.7925293948
1509PhosphorylationEESPFVPYDFMNSST
CCCCCCCCCCCCCCC		19.2625293948
1514PhosphorylationVPYDFMNSSTSPASP
CCCCCCCCCCCCCCC		24.1725293948
1515PhosphorylationPYDFMNSSTSPASPP
CCCCCCCCCCCCCCC		28.0925293948
1516PhosphorylationYDFMNSSTSPASPPG
CCCCCCCCCCCCCCC		38.2525293948
1517PhosphorylationDFMNSSTSPASPPGS
CCCCCCCCCCCCCCC		22.0325159016
1520PhosphorylationNSSTSPASPPGSIGD
CCCCCCCCCCCCCCC		34.7027180971
1524PhosphorylationSPASPPGSIGDGWPR
CCCCCCCCCCCCCCC		29.2225293948
1534PhosphorylationDGWPRAKSPNGSSSV
CCCCCCCCCCCCCCC		23.7126745281
1538PhosphorylationRAKSPNGSSSVNWPP
CCCCCCCCCCCCCCC		26.5323984901
1539PhosphorylationAKSPNGSSSVNWPPE
CCCCCCCCCCCCCCC		39.4423984901
1540PhosphorylationKSPNGSSSVNWPPEF
CCCCCCCCCCCCCCC		22.5923984901
1622O-linked_GlycosylationNYNVPLSSTAQSTSA
CCCCCCCCCCCCCCC		35.1330059200
1623O-linked_GlycosylationYNVPLSSTAQSTSAR
CCCCCCCCCCCCCCC		25.9130059200
1637PhosphorylationRNSDSKLTWSPGSVT
CCCCCCCEECCCCCC		27.8623984901
1639PhosphorylationSDSKLTWSPGSVTNT
CCCCCEECCCCCCCC		17.7226745281
1642PhosphorylationKLTWSPGSVTNTSLA
CCEECCCCCCCCHHH		29.2023984901
1644PhosphorylationTWSPGSVTNTSLAHE
EECCCCCCCCHHHHH		34.1826745281
1700PhosphorylationWGNSDARYTPGSSWG
CCCCCCCCCCCCCCC		21.00-
1701PhosphorylationGNSDARYTPGSSWGE
CCCCCCCCCCCCCCC		18.67-
1804PhosphorylationQSQSLTPSPGWQSLG
HCCCCCCCCCCHHCC		30.7029514104
1819PhosphorylationSSQSRLGSLDCSHSF
CCCHHCCCCCCCCCC		26.15-
1825PhosphorylationGSLDCSHSFSSRTDV
CCCCCCCCCCCCCCC		15.55-
1875PhosphorylationSSDPRGISSPSPINA
CCCCCCCCCCCCCCE		38.7326643407
1876PhosphorylationSDPRGISSPSPINAF
CCCCCCCCCCCCCEE		27.7226643407
1878PhosphorylationPRGISSPSPINAFLS
CCCCCCCCCCCEEEC		40.1226643407
1885PhosphorylationSPINAFLSVDHLGGG
CCCCEEECCCCCCCC		21.0323984901
1895PhosphorylationHLGGGGESM------
CCCCCCCCC------		32.8226643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TNR6A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNR6A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNR6A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TNR6A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNR6A_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-976, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory