SHCBP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHCBP_MOUSE
• UniProt AC: Q9Z179
• Protein Name: SHC SH2 domain-binding protein 1
• Gene Name: Shcbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 668
• Subcellular Localization: Midbody . Cytoplasm, cytoskeleton, spindle . Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis.
• Protein Description: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells..
• Protein Sequence: MADDLRAGGVLEPIAMVPPRPDLAAEKEPASWKEGLFLDADPCSDQGYHANPGATVKTLIPEGKTPFPRIIQTNELLFYERFRAYQDYILADCKASEVKEFTVSFLEKVLEPSGWWAVWHTNVFEVLVEVTNVDFPSLKAVVRLAEPCIYESKLSTFTLANVKELLDLKEFHLPLQELWVVSDDSHEFHQMALAIEHVRFFYKHIWRSWDEEEEDEYDYFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQGKGTRQNGQKVIHVVSSTMKTGLLRSLFKDRFCEESCKEETEIKFHSDLLSGINACYDGDTVIICPGHYVVHGTCSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGMDVKISGIKFIQHDSVEGILIIHHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNGIHHCKEGILIKDFLDEHYDIPKISMINNVIHNNEGYGVVLVKPTIFCDLQENTQDEINDNMVQKNKEADVTEGLDLEEMLQCVASKMEPYATADFNEQAKGNCEIINELLAISMQKGRMKKRLSELGITQADDNIMSQEMFIEIMGNQFKWNGKGSFGTFLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADDLRAGG ------CCCCCCCCC	21.01	-
31	Phosphorylation	AAEKEPASWKEGLFL CCCCCCCCCCCCEEE	49.77	-
44	Phosphorylation	FLDADPCSDQGYHAN EECCCCCCCCCCCCC	38.05	22006019
217	Phosphorylation	DEEEEDEYDYFVRCV CCCCCCCCCCHHHHH	28.41	22817900
266	Phosphorylation	RKFLNLRSSLSNCNS HHHHHHHHHHHCCCC	38.50	26643407
267	Phosphorylation	KFLNLRSSLSNCNSD HHHHHHHHHHCCCCC	29.41	26643407
269	Phosphorylation	LNLRSSLSNCNSDSE HHHHHHHHCCCCCCH	41.08	26643407
273	Phosphorylation	SSLSNCNSDSEQENI HHHHCCCCCCHHHHH	44.72	26643407
275	Phosphorylation	LSNCNSDSEQENISM HHCCCCCCHHHHHHH	40.79	23649490
281	Phosphorylation	DSEQENISMVEGLNL CCHHHHHHHHHHHHH	28.49	26643407
609	Glutathionylation	NEQAKGNCEIINELL CHHCCCCCHHHHHHH	5.61	24333276
630	Phosphorylation	GRMKKRLSELGITQA CCCHHHHHHCCCCHH	34.50	26643407
635	Phosphorylation	RLSELGITQADDNIM HHHHCCCCHHCCCCC	18.86	26643407
643	Phosphorylation	QADDNIMSQEMFIEI HHCCCCCCHHHHHHH	21.13	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHCBP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHCBP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHCBP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX49_HUMAN	DDX49	physical	20360068
SHCBP_HUMAN	SHCBP1	physical	20360068
RGAP1_HUMAN	RACGAP1	physical	20360068
GPC5_HUMAN	GPC5	physical	20360068
PDIA4_HUMAN	PDIA4	physical	20360068
ACOT9_HUMAN	ACOT9	physical	20360068
KIF23_HUMAN	KIF23	physical	20360068
LIN41_MOUSE	Trim71	physical	22508726
MYL6_HUMAN	MYL6	physical	26496610
AAAT_HUMAN	SLC1A5	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
KIF23_HUMAN	KIF23	physical	26496610
ABC3B_HUMAN	APOBEC3B	physical	26496610
YMEL1_HUMAN	YME1L1	physical	26496610
TRAM1_HUMAN	TRAM1	physical	26496610
ACOT9_HUMAN	ACOT9	physical	26496610
RGAP1_HUMAN	RACGAP1	physical	26496610
ATD3A_HUMAN	ATAD3A	physical	26496610
KLHL7_HUMAN	KLHL7	physical	26496610
MICA3_HUMAN	MICAL3	physical	26496610
DERL1_HUMAN	DERL1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.